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The Effect of Artemisia Capillaris Crude Juice Extract on $CCl_4$ Induced Liver Damage in Dogs  

이우열 (경북대학교 수의과대학)
이성동 (경북대학교 수의과대학)
손상익 (경북대학교 수의과대학)
장혜숙 (일본 북해도대학 수의학과)
김영홍 (경북대학교 수의과대학)
오태호 (경북대학교 수의과대학)
엄기동 (경북대학교 수의과대학)
장광호 (경북대학교 수의과대학)
박승춘 (경북대학교 수의과대학)
Publication Information
Journal of Veterinary Clinics / v.20, no.3, 2003 , pp. 389-395 More about this Journal
Abstract
Artemisia is a major edible vegetable in Korea and it has traditionally been used as a herbal medicine for the treatment of coughing, abdominal pain, indigestion, bleeding, jaundice, chronic liver disease and diabetes. However the biological and pharmacological actions of the herb have not been studied well. Recently it is known to possess antibacterial, antihelmintic and antifertility activities. But the effect of Artemisia capillaris extract on carbon tetrachloride($CCl_4$) induced liver damage in dogs have not been reported yet. This study was designed to investigate the effect .of Artemisia capillaris crude juice extract on $CCl_4$ induced liver damage in dogs. 30 clinically healthy dogs were divided into 2 groups: crude Artemisia capillaris juice treated group(CEC group) and carbon tetrachloride($CCl_4$) administerd group. The results are as follows: I. The degree of increase in AST activity and ALT activity in CEC group was lower than that in $CCl_4$ group and the recovery in CEC group was faster than that in $CCl_4$ group. 2. Changes of ALP concentration in CEC group were significant(P < 0.05) but changes of Total-bilirubin concentration were not significant(P < 0.05) in both groups. 3. The recovery of GGT concentration in CEC group was faster than that in $CCl_4$ group. 4. Hematological changes other than MCHC were significant(P < 0.05) in CEC group only and changes of GSH and Met-Hb concentration were significant(P < 0.05) in $CCl_4$ group.
Keywords
Artemisia capillaris; AST; ALT; carbon tetrachloride($CCl_4$); dog;
Citations & Related Records
Times Cited By KSCI : 11  (Citation Analysis)
연도 인용수 순위
1 Inhibitory Effects of Crude Polysaccharide of Water Extract of Artemisia iwayomogi Kitamura on Melanin Biosynthesis /
[ Chun,H.J.(et al.) ] / Yakhak Hoeji   과학기술학회마을
2 Vasorelaxants from Chinese herbs, emodin and scoparone, possess immunosuppressive properties /
[ Huang,H.C.;Chu,S.H.;Chao,P.D. ] / Eur. J. Pharmacol   DOI   ScienceOn
3 Studies on the Physiological Functionality of Pine Needle and Mugwort Extracts /
[ Kang,Y.H.;Park,Y.K.;Oh,S.R.;Moon,K.D. ] / Kor. J. Food. Sci. Technol.
4 Antioxidant and Hepatoprotective Actions of the Medicinal Herb Artemisia campestris from Okinawa Islands /
[ Yoko Aniya(et al.) ] / Biol. Pharm. Bull.   DOI   ScienceOn
5 Quantitative analysis of 6,7-dimethylesculetin and capillarisine in Artemisia capillaris Thunb. and prescriptions containing the crude drug /
[ Wang,X.J.;Sun,H.;Liu,Z.S. ] / Zhongguo Zhong Yao Za Zhi
6 Effect of Mugwort on Inhibition of the Duodenal Ulcer Induced by Cysteamine Administration /
[ Lee,J.Y.;Lee,S.S. ] / Korean J. Nutrition   과학기술학회마을
7 Hypoglycaemic effect of Artemisia herba alba. Ⅱ. Effect of a valuable extract on some blood parameters, in diabetic animals /
[ Loai Al-Shamaony;Shahba,M.(et al.) ] / Journal of Ethno-pharmacology   DOI   ScienceOn
8 Growth Characteristics and Chemical Components in Local Collection of Artemisia sp. /
[ Rho,T.H.(et al.) ] / Korean J. Medicinal Crop Sci.
9 Metabolites of Colletotrichum gloeosporioides, and endophytic fungus in Artemisia mongolica /
[ Zou,W.X.;Meng,J.C.(et al.) ] / J. Nat. Prod.   DOI   ScienceOn
10 Studies on the activities of tannins and related compounds from medicinal plants and drugs. Ⅶ. Effects of extracts of leaves of Artemisia species, and caffeic acid and chlorogenic acid on lipid metabolic injury in rats fed peroxidized oil /
[ Kimura,Y.;Okuda,H.;Okuda,T.;Hatano,T.;Agata,I.;Arichi,S. ] / Chem. Pharm. Bull.   DOI   ScienceOn
11 Biological Activity fo the Soluble Ectracts from Artemisia princeps var orientalis Acted on Cardiovascular System /
[ Lim,S.S.;Lee,J.H. ] / Korean J. Nutrition   과학기술학회마을
12 Studies on the Chemical Components and Biological Activities of Edible plants in Korea(Ⅵ)- Anti-inflammatory and Analgesic Effects of Cedrela sinensis, Oenanthe javanica and Artemisia princeps var. orientalis- /
[ Park,J.C.(et al.) ] / J. Korean Soc. Food Sci. Nitr.   과학기술학회마을
13 Effects of Artemisia pallens Wall. on blood glucose levels in normal and alloxan-induced diabetic rats /
[ A.Subramoniam;P.Pushpangadan(et al.) ] / Journal of Ethnopharmacology   DOI   ScienceOn
14 Antimutagenicity and Cyto-toxicity of Artemisia iwayomogi Kitamura Extracts /
[ Ham,S.S.;Chung,C.K.(et al.) ] / J. Korean Soc. Food. Sci. Nutr.
15 Some Coumarins from Artemisia Keiskeana (Compositae) /
[ Jang,W.Y.;Kwak,J.H. ] / Kor. J. Phamacog
16 Effects of Artemisia Princepa var Orientalis and Circium Japinicum var Ussuriense on Liver Function, Body Liquid and Bile Acid of Hyperlipidemic Rat /
[ Lim,S.S.;Kim,M.H.;Lee,J.H. ] / Korean J. Nutrition   과학기술학회마을
17 Volatile components Artemisia apiacae Herba /
[ Kim,O.C.;Jang,H.J. ] / Agricultural Chemistry and Biotechnology
18 Immunological mechanisms of antitumor activity of some kinds of crude drug on tumor necrosis factor production /
[ Xu,Q.;Moris,H.;Sakamoto,O.;Uesugi,Y.;Koda,A. ] / Int. J. Immunopharmacol   DOI   ScienceOn
19 Improved method for the determination of blood glutathione /
[ Beutler,E.;Duron,O.;Kelly,B.M. ] / J. Lab Clin Med.
20 Antipyretic and anti-inflammatory effects of Artemisia annua L /
[ Huang,L.;Liu,J.F.(et al.) ] / Zhongguo Zhong Yao Za Zhi
21 Inhibitory Effect of Artemisia princeps Pampan. Extract on Growth of Cancer Cell Lines /
[ Hwang,Y.K.(et al.) ] / Korean. J. Nutrition   과학기술학회마을
22 Effects of Artemisia iwayomogi Kitamura Ethanol Extract on Lowering Serum and Liver Lipids in Rats /
[ Nam,S.M.(et al.) ] / J. Korean Coc. Food Sci. Nutr.   과학기술학회마을
23 Effect of Mugwort-water Extracts on Cadmium Toxicity in Rats /
[ Lee,C.H.;Han,K.H.;Choi,I.S.;Kim,C.Y.;Cho,J.K. ] / Kor. J. Food. Sci. Ani. Resour.
24 Cytotoxic Components of Artemisia princeps /
[ Ryu,S.Y.;Kim,J.O.;Choi,S.U. ] / Planta Medica.
25 Effect of Artemisia Princeps Var Orientalis and Circium Japonicum Var Ussuriense on Serum Lipid of hyperlipidemic Rat. /
[ Lim,S.S.;Lee,J.H. ] / Korean J. Nutrition   과학기술학회마을
26 What is In-Jin-Sook Artemisia capillaris, Artemisia iwayomogi, and Artemisia annua /
[ Ahn,B.M. ] / The Korean Journal of Hepatology
27 Studies on Volatil Oil Constituents in Artemisia sp. Isolation and Determination of Camphor by Gas Chromatography /
[ Hahn,D.R.;Kim,I.H. ] / Kor. J. Pharmacog.
28 Antifungal activity of essential oil from Artemisia afra Jacq. /
[ Gundidza,M. ] / Cent Afr J. Med
29 New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris /
[ Wu,T.S.;Tsang,Z.J.;Wu,P.L.;Lin,F.W.;Li,C.Y.;Teng,C.M.;Lee,K.H. ] / Bioorg Med Chem   DOI   ScienceOn
30 Effects of Artemisia selengensis Methanol Extract on Ethanol-induced Hepatotoxicity in Rat Liver /
[ Kim,K.S.;Lee.M.Y. ] / J. Kor. Soc. Food. Sci. Nutr.   과학기술학회마을
31 Effects of Artemisia iwayomogi Extracts on Antioxidant Enzymes in Rats Administered Benzo(α) pyrene /
[ Nam,S.M.;Chung,C.K.(et al.) ] / J. Korean Soc. Food Sci. Nutr.   과학기술학회마을
32 Effects of Scoparone and Artemisia asiatica Nakai on the function of Liver /
[ Joo,M.K.;Choi,S.Y.(et al.) ] / Kor. Soc. Food. Sci. Nutr.
33 Isolation and Identification of Flavonoids from Ethanol Extracts of Artemisia vulgaris and Their Antioxidant Activity /
[ Lee,S.J.;Chung,H.T.;Lee,I.K.;Yoo,I.D. ] / Korean J. Food Sci. Technol.
34 Sampling and physico-chemical analysis of precipitation : a review /
[ Krupa,S.V. ] / Environ Pollut   DOI
35 Immuno-suppressive action of Qinghaosu /
[ Shen,M.;Ge,H.L.;He,Y.X.;Song,Q.L.;Zhang,H.Z. ] / Sci. Sin[B]
36 Micro-determination of methemoglobin and normal value /
[ Nakamura,I.;Nishid,N.;Maruyama,H.(et al.) ] / St. Marianna Med. J.
37 Bioactive constituents and Utilities of Artemisia sp. as Medicinal herb and Foodstuff /
[ Lee,S.D.;Park,H.H.;Kim,D.W.;Bang,B.H. ] / Korean J. Food & Nutr.   과학기술학회마을