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Sodium Carboxymethylcellulose and Hyaluronic Acid on Prevention of Intra-abdominal Adhesion in Rats  

한태성 (제주대학교 수의학과)
이주명 (제주대학교 수의학과)
윤영민 (제주대학교 수의학과)
강태영 (제주대학교 수의학과)
신태균 (제주대학교 수의학과)
강윤호 (제주대학교 수의학과)
김남중 (LG 생명과학기술원)
김희석 (제주대학교 수의학과)
이경갑 (제주대학교 수의학과)
Publication Information
Journal of Veterinary Clinics / v.20, no.3, 2003 , pp. 323-327 More about this Journal
Abstract
This study has been conducted to compare the efficacy of sodium carboxymethylcellulose (SCMC) and hyaluronic acid (HA) on prevention of adhesion after artificial wound was induced in intestine. 1 % SCMC and 0.3% HA solution and saline solution were respectively administered to abdominal cavity. Each of the three groups consists of 11 rats. The abdominal cavity of each rat was coated with 2 ml of the allocated solution just after the abdomen was cut open, and it was coated with each solution of 1 ml before abrasion were caused on the cecum, the ascending colon and the transverse colon. Then, an additional 1 ml solution was injected before the abdomen was closed. On day 14 after the operation, each adhesion formation was evaluated at the score of 0-4. The HA group and SCMC group showed significantly lower adhesion scores than control group in all regions(P< 0.05). The adhesion scores of ascending colon, transverse colon and no abrasion region of the viscera showed little difference between HA group and SCMC group(P< 0.05), but the effect of adhesion reduction showed higher tendency in the HA group than the SCMC. The adhesion score of the cecum was significantly lower in HA group than SCMC group(P< 0.05). In conclusion, the SCMC solution and HA solution were effective on prevention of abdominal adhesion resulting from the celiotomy. Among of them, the HA solution could be more effective on prevention of adhesion than SCMC solution.
Keywords
SCMC; HA; cecum; colon;
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Times Cited By KSCI : 1  (Citation Analysis)
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