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The Efficacy of Conjugated Linoleic Acid and Carprofen in Progression of Early Stage of Experimentally Induced Osteoarthritis in Dogs  

Park, Se-il (Department of Veterinary Medicine Kyungpook National University)
Bae, Jae-sung (Department of Veterinary Medicine Kyungpook National University)
Kwon, Young-sam (Department of Veterinary Medicine Kyungpook National University)
Jang, Hwan-soo (Department of Veterinary Medicine Kyungpook National University)
Li, Wen-xue (Department of Veterinary Medicine Kyungpook National University)
Lim, Jae-hyun (Department of Veterinary Medicine Kyungpook National University)
Eom, Ki-dong (Department of Veterinary Medicine Kyungpook National University)
Kim, Jung-eun (Department of Veterinary Medicine Kyungpook National University)
Jang, Kwang-ho (Department of Veterinary Medicine Kyungpook National University)
Publication Information
Journal of Veterinary Clinics / v.20, no.3, 2003 , pp. 278-285 More about this Journal
Abstract
This study was performed to compare early stage changes following the administrations of Conjugated Linoleic Acid (CLA), Carprofen and their combinations in the experimental canine cranial cruciate ligament rupture. Twenty five mongrel dogs were divided into five groups; Groups 1, 2, and 3 received a sectioning the cranial cruciate ligament (CCL) of the right stifle joint, and were administered CLA (250 mg/kg/day/orally), carprofen (4.4 mg/kg/day/orally), and their combinations for 4 weeks beginning 4 weeks postsurgery, respectively. Group 4 received sectioning CCL and no treatment. Group 5 was composed of unoperated normal dogs. The macroscopic observation of cartilage erosions on both the condyles and plateaus were evaluated, and the severity of the cartilage lesions and synovial inflammation was examined histologically at eight weeks after surgery. Histological examinations including hematoxylin and eosin stain, standard toluidine blue method, PAS technique and Masson trichrome technique, hematologic and radiographic evaluation were perfonned after experimental surgery. Slight yellowish discoloration of the surface was found in some of the experimental dogs. However macroscopic findings showed no significant differences among the groups. In radiographic findings, cranial displacement of the proximal tibia relative to the femoral condyles in all groups was observed but no significant differences among the groups was seen. This study showed that oral administration of CLA, carprofen and their combinations revealed no early stage change in the canine stifle joint following experimental rupture of the cranial cruciate ligament.
Keywords
Conjugated Linoleic Acid (CLA); Carprofen; Cranial cruciate ligament; Dog; Conjugated Linoleic Acid; carprofen;
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