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CLA Treatment Effect on Immunsuppressive Effect of Corticosteroid in Mouse  

박종국 (건국대학교 수의과대학)
김진영 (건국대학교 수의과대학)
이병한 (건국대학교 수의과대학)
임좌진 (건국대학교 수의과대학)
정병현 (건국대학교 수의과대학)
Publication Information
Journal of Veterinary Clinics / v.20, no.1, 2003 , pp. 79-85 More about this Journal
Abstract
Dietary conjugated linoleic acid(CLA) has been shown to affect immune function. Thus, the objective of this study was to investigate the effects of CLA on the mice that treated prednisone. Mice were randomized into 6 groups and fed diet containing either 0(control, P), 0.5%(CLA1, CP1) or 1.5%(CLA2, CP2) CLA for Sweets. Before 1 week of finishing diet supplement CP1, CP2, and P group treated the prednisone by subcutaneous injection. The levels of serum immunoglobulin A, G, E, gut lumen s-IgA, MLN immunoglobulin A, body weight, mucosal protein was compared. The level of serum IgA in CLA1, CLA2, CP1, and CP2 group increased, while which of P group was decreased. The level of serum IgG in CLA 1 group increased, while which of the other group no differences. Serum IgE level showed no difference and the immunoglobulin production in MLN lymphocyte in CLA 1 group increased. The level of gut lumen s-IgA in P group showed decreased, while which of the other group showed no differences. These results support the view that CLA supplement partially enhance the cell-mediated immunity and overcome the immunosuppressive effect of prednisone.
Keywords
Conjugated linoleic acid; prednisone; immunoglobulin; mucosal protein;
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  • Reference
1 Conjugated Linoleic Acids Modulates Tissue Levels of Chemical Mediators and Immunoglobulins in Rats /
[ Michihiro Sugano;Akira Tsujita;Masao Yamasaki;Miwa Noguchi;koji Yamada ] / Lipids
2 Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic dervativies of linoleic acid /
[ Ha YL;Storkson J;Pariza MW ] / Cancer Research
3 Glucocorticoid regulation of the humoral immune system: In vivo effects of dexamethasone on IgA and IgG in serum and at mucosal surfaces /
[ Charles R Wira;Carola P Sandoe;Micjhel G Stelle ] / The journal of immunology
4 Steroid therapy can modulate gut barrier function, host defense and survival in thermally injury mice /
[ Luca Gianotti;J Wesley Alexander;Ryoji Fukushima;Tonyia Pyles ] / Journal of surgical research   DOI   ScienceOn
5 Protection of conjugated linoleic acids against 2-amino-3-methlimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms /
[ Liew C;Schut HA;Chin SF;Pariza MW;Dashwood RH ] / Carcinogenesis   DOI   ScienceOn
6 The effect of dexamethasone administration on rat intestinal permeability : The role of bacterial adherence /
[ James spitz;Gail Hecht;Mildred Taveras;Eric Aoys;John Alverdy ] / Gastroenerology   DOI
7 The effect of conjugated linoleic acid on fat to lean repartitioning and feed conversion in pigs /
[ Dugan ME;Aalhus JL;Schaefer AL;Kramer JKG ] / Canadian Journal of Animal Science   DOI   ScienceOn
8 Effect of conjugated linoleic acid on fat pad weights and celluarity in Sprague-dawley andzucker rats /
[ Sisk M;Azain MJ;Hausmann DB;Jewell DE ] / FASEB J
9 Conjugate linoleic acid: a potent anticarcinogen found in milk fat /
[ Kelly, ML;Bauman DE ] / proc Coenell Nutr Conf Feed Manuf
10 Immune modulation by altered nutrient metabolism : nutrional control of immune-induced growth depression /
[ Cook ME;Miler CC;Pariza M ] / Poultry science   DOI   ScienceOn
11 /
[ Thom E ] / A pilot study with the aim of studying the efficiency and tolerability of Tonalin CLA he body composition in humans
12 Mammary cancer prevention by conjugated dienoic derivative of linoleic acid /
[ Ip C;Chin SF;Scimeca JA;Pariza MW ] / Cancer Research
13 Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion /
[ Belury MA;Nikel KO;Bird CE;Wu Y ] / Nutritional an Cancer   DOI   ScienceOn
14 Total parenteral nutrition promotes bacterial translocation from the gut /
[ Alverdy JC;Aoys E;Moss GS ] / Surgery
15 Conjugated Linoleic Acid Modulates Hepatic Lipid Composition in Mice /
[ Belury MA;Kempa-Steczko A ] / Lipids   DOI   ScienceOn
16 Stresseffects corticosteroid and immunoglobulin concentrations in male house mice(Mus musculus) and prairie voles(Microtus ochrogaster) /
[ DeVries AC;Gerber JM;Richardson HN;Moffatt CA;Demas GE;Tayman SE;Nelson RJ ] / Comp Biochem Physiol A Physiol   DOI
17 Effect of Conjugated Linoleic Acid on Body Composition Changes in Mice /
[ Park Y;Albright KJ;Liu W;Storkson JM;Cook ME;Pariza MW ] / Lipids   DOI   ScienceOn
18 Induction of gut mucosal immune response: Importance of genetic background and Th1/Th2 cross-regulation /
[ Kjerrulf M;Grdic D;Kopf M;Lycke N ] / Scan J Immunol   DOI   ScienceOn
19 Anticarcinogens from fried ground beef: hear-altered derivatives of linoleic acid /
[ Ha YL;Grimm NK;Pariza MW ] / Carcinogenesis   DOI   ScienceOn
20 Effect of dietary fat and protein on fatty and flow to the duodenum and in milk produced by dairy cows /
[ Klusmeryer;Clark ] / J Biohydrogenation of unsaturated fatty acids J Dairy Science
21 Murine Lupus Nephritis Effects of glucocorticoid on circulating and tissue bound immunoreactants /
[ Tito C;Kerry G;Norman AG ] / Laboratory Investigation
22 Effects of corticosteroids on immunity in man. Ⅰ. Decereas serum IgG concenturation caused by 3 or 5 days of high doses of methylprednesolone /
[ Butler WT;Rossen RD ] / J Clin Invest   DOI
23 Secretory immunoglobulin A, intestinal Mucin and mucosal permeability in nutritionally induced bacterial translocation in rats /
[ Georg Spaeth MD;Thomas Gottwald MD;Robert D Specian PhD;Markh R Mainsous MD;Rodney D Berg PhD;Edwin A Deitch MD ] / Annals of Surgery   DOI   ScienceOn
24 The antiinflammatory effects of glucocorticoids: a brief review of literature /
[ Dannenberg AM Jr ] / Infammation   DOI
25 Arginine Gutamine, and dehydroepiadrenosterone reverse the immunosuppressive effect of prednisone during gut-devred sepsis /
[ Roberto Gennari;J Wesley Alexander ] / Crit Care Med   DOI   ScienceOn
26 Fedding conjugated linoleic acid to animals partially overcomes catabolic responses due to endotoxin injection /
[ Miller CC;Park Y;Pariza MW;Cook ME ] / Biophy Res Commu   DOI   ScienceOn
27 Influence of supplemental fats on reproductive tissues and performance of lactating cows /
[ Staples CR;Burke JM;Thatcher WW ] / J Dairy Science
28 The effects of prednisone and azathioprine on circulating immunoglobulin levels and lymphocyte subpopulations in normal dogs /
[ Rinkardt NE;Kruth SA;Kaushik A ] / Can J Vet Res
29 The inhibitory effect on immunoglobulins /
[ Settipan GA;Pudupakkam RK;McGowan JH ] / J Allergy Clin Immunol   DOI