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Effect of Biologically Active Isomers of Conjugated Linoleic Acid on Immune Response and Body Composition in Mice  

최미현 (건국대학교 수의과대학)
김진영 (건국대학교 수의과대학)
이병한 (건국대학교 수의과대학)
임좌진 (건국대학교 수의과대학)
정재홍 (안산공과대학)
정병현 (건국대학교 수의과대학)
Publication Information
Journal of Veterinary Clinics / v.20, no.1, 2003 , pp. 66-73 More about this Journal
Abstract
Numerous physiological effects are attributed to conjugated linoleic acid(CLA). The purpose of this study is to consider these effects with respect to the cis-9, trans-11 and trans-10, cis-12 CLA isomer. Both isomers are natural products. The c9,t11-CLA isomer is the principal dietary form of CLA, but the concentrations of this isomer and the t10,c12-CLA Isomer in dairy products or beef vary depending on the diet fed to cows or steers, respectively. The influence of dietary CLA isomers on the immune response was examined, body weight and weight ratio of organ to body of Balb/C mice. Mice were divided into four groups of 8 mice. Balb/C mice were fed the experimental diets supplemented with 1% CLA (c9,t11-CLA isomer : t10,c12-CLA isomer = 2:3) (Group 1), 1% CLA (c9,t11-CLA isomer t10,c12-CLA isomer : 1:1) (Group 2), 1% safflower oil (Group 3) or nothing (Control) for 3 weeks. After 3 weeks, serum, gut lumen lavage, fat, liver, spleen and thymus were taken. Measurement of total immunoglobulin were executed using sandwich ELISA. Serum levels of IgA and IgM showed that group fed with t10,c12-CLA isomer significantly were higher than group fed with c9,tl1-CLA isomer. In addition serum level of IgG showed that group fed with t10,c9-CLA isomer significantly were lower than group fed with c9,tl1-CLA isomer. However, no significantly differences were observed in the serum IgE and secretory IgA. Weight ratio of spleen to body showed no significant differences. In weight ratio of liver and thymus to body, tl0,c9-CLA isomer significantly were respectively higher than group fed with c9,t11-CLA isomer. In weight ratio of fat to body, tl0,c9-CLA isomer significantly were respectively lower than group fed with c9,tl1-CLA isomer. In conclusion, t10,c12-CLA isomer produced a situation favorable for immunopotentiative effect and body composition. But it should be protected against hepatomegaly induced lipid accumulation in liver.
Keywords
cis-9; trans-11 CLA isomer; trans-10; cis-12 CLA isomer; immunoglobulin; body composition; mice;
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  • Reference
1 The effects of dietary conjugated nonadecadienoic acid on body composition in mice /
[ Park Y;Pariza MW ] / Biochimica et Biophysica Acta   DOI   ScienceOn
2 Effect of dietary supplementation with either conjugated linoleic acid (CLA) or linoleic acid rich oil on the CLA content of lamb tissue /
[ Mir Z;Rushfeldt ML;Mir PS(et al.) ] / Small Ruminant Research   DOI   ScienceOn
3 Protection of conjugated linoleic acids against 2-amino-3-methlimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms /
[ Liew C;Schut HA;Chin SF(et al.) ] / Carcinogenesis   DOI   ScienceOn
4 Mechanisms of Action of Conjugated Linoleic Acid:Evidence and Speculation /
[ Pariza M;Park Y;Cook ME ] / Pro Soc Exp Biol
5 Immune modulation by altered nutrient metabolism: nutrional control of immune-induced growth depression /
[ Cook ME;Miler CC;Pariza M ] / Poultry science   DOI   ScienceOn
6 Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake /
[ DeLany JP;Blohm F;Truett AA(et al.) ] / Am J Physiol
7 Anticarcinogens from fried ground beef: hear-altered derivatives of linoleic acid /
[ Ha YL;Grimm NK;Pariza MW ] / Carcinogenesis   DOI   ScienceOn
8 The biologically active isomers of conjugated linoleic acid /
[ Pariza MW;Park Y;Cook ME ] / Progress in Lipids Research   DOI   ScienceOn
9 The effect of conjugated linoleic acid on fat to lean repartitioning and feed conversion in pigs /
[ Dugan ME;Aalhus JL;Schaefer AL(et al.) ] / Canadian Journal of Animal Science   DOI   ScienceOn
10 Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic dervativies of linoleic acid /
[ Ha YL;Storkson J;Pariza MW ] / Cancer Research
11 Conjugated Linoleic Acid Modulates Hepatic Lupid Composition in Mice /
[ Belury MA;Kempa-Steczko A ] / Lipids   DOI   ScienceOn
12 Biohydrogenation of Unsaturated Fatty Acids /
[ Hughes PE;Hunter WJ;Tove SB ] / The Journal of Biological Chemistry
13 Isotype determination of antibodies by sandwich ELISA /
[ Cochet O;Teillaud J;Sautes C ] / Immunological Techniques Made Easy
14 Effects of conjugated linoleic acid(CLA) isomers on lipid levels and peroxisome proliferation in the hamster /
[ de Deckere EAM;van Amelsvoort JMM;McNeil GP(et al.) ] / British Journal of Nutrition
15 Dietary conjugated linoleic acid induces peroxisome specific enzyme accumulation and ornithine decarboxylase activity in mouse liver /
[ Belury MA;Moya-Camarena SY;Liu K(et al.) ] / Nutritional Biochemistry   DOI   ScienceOn
16 Dietary Conjugated Linoleic Acid Normalizes Impaired Clucose Tolerance in the Zucker Diabetic Fatty fa/fa Rat /
[ Houseknecht KL;Vanden Heuvel JP;Moya-Camarena(et al.) ] / Biochem. Biophys. Res. Comm   DOI   ScienceOn
17 Conjugated Linoleic Acid Modulates Tissue Levels of Chemical Mediators and Immunoglobulins in Rats /
[ Sugano M;Tsujita A;Yamasaki M(et al.) ] / Lipids   DOI   ScienceOn
18 Conjugated Linoleic Acid Supplementation Reduce Adipose Tissue by Apoptosis and Develops Lipodystrophy in Mice /
[ Tsuboyama-Kasaoka N;Takahashi M;Tanemura K(et al.) ] / Diabetes   DOI   ScienceOn
19 The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells /
[ Palombo JD;Ganguly A;Bistrian BP(et al.) ] / Cancer Lett   DOI   ScienceOn
20 Mammary cancer prevention by conjugated dienoic derivative of linoleic acid /
[ lp C;Chin SF;Scimeca JA(et al.) ] / Cancer Research
21 Trans-10,cis-12, but not cis-9, trans-11, conjugated linoleic acid attenuates lipogenesis in primary culture of stromal vascular cells from human adipose tissue /
[ Brown JM;Halvorsen YD;Lea-Currie YR(et al.) ] / J Nutr   DOI
22 Potential Health Benefits of Conjugated Linoleic Acid /
[ Scimeca JA;Miller GD ] / Journal of the American College of Nutrition   DOI
23 Dietary Conjugated Linoleic Acid Influences the Immune Response of Young and Olc C57BL/6NCrlBR Mice /
[ Hayek MG;Han SN;Wu D(et al.) ] / J Nutr   DOI
24 Evidence That the trans-10,cis-12 Isomer of Conjugated Linoleic Acid Induces Body Composition Changes in Mice /
[ Park Y;Storkson JM;Albright KJ(et al.) ] / Lipids   DOI   ScienceOn
25 Modulation of Arachidonic Acid Distribution by Conjugated Linoleic Acid Isomers and Linoleic Acid in MCF-7 and SW480 Cancer Cells /
[ Miller A;Stanton C;Devery R ] / Lipids   DOI   ScienceOn
26 A Simple Method of Preparation of Methyl trans-10,cis-12- and cis-9,trans-11-Ocradecadienoates from Methy Linoleate /
[ Berdeaux O;Voinot L;Angioni E(et al.) ] / JAOCS   DOI   ScienceOn
27 Conjugated linoleic acid and atherosclerosis in rabbits /
[ Lee KN;Kritchevsky D;Pariza MW ] / Arherosclerosis   DOI   ScienceOn
28 Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse /
[ West DB;Delany JP;Camet PM(et al.) ] / Am J Physiol
29 The Pole of Phenolics, Conjugated Linoleic Acid, Carnosine, and Pyrroloquinoline Quinone as Nonseesntial Dietary Antioxidants /
[ Decker EA ] / Nutrition Reviews   DOI   ScienceOn
30 Effect of Conjugated Linoleic Acid on Body Composition Changes in Mice /
[ Park Y;Albright KJ;Liu W(et al.) ] / Lipids   DOI   ScienceOn