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Mutation of Canine Tumor Suppressor Gene p53 in a Mammary Gland Adenocarcinoma and a Malignant Mast Cell Tumor  

Lee, Chung-ho (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University)
Kweon, Oh-kyeong (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University)
Publication Information
Journal of Veterinary Clinics / v.19, no.2, 2002 , pp. 195-198 More about this Journal
Abstract
To identify mutations in exons 5 to 8 of the p53 tumor suppressor gene, we have analysed in 12 spontaneous canine tumors. In a malignant mast cell tumor, a 1 base pair alteration AGT $\longrightarrow$AGC (silent point mutation, serine) in codon 249 in exon 8 was detected. And the mammary gland adenocarcinoma was found to have a mis-sense point mutation (CCT $\longrightarrow$ TCT) in codon 285 in exon 8.
Keywords
dog; mutation; p53; tumor;
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