Browse > Article

Analysis of Gender Differences in Physician's Desk Reference  

Heo, Jung-Sun (Graduate School of Clinical Health Sciences, Ewha Womans University)
Kim, Kyung-Hee (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University)
Yoon, In-Kyung (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University)
Kim, Hyun-Ju (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University)
Kim, You-Jin (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University)
Choi, Jong-Min (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University)
Lee, Byeong-Gu (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University)
Lee, Hwa-Jeong (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University)
Gwak, Hye-Sun (College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University)
Publication Information
Korean Journal of Clinical Pharmacy / v.21, no.1, 2011 , pp. 22-29 More about this Journal
Abstract
Purpose: This study aims to investigate how gender-based differences are actually reflected on drug approval. Methods: Data on gender-based differences of drugs were analyzed by searching PDR (Physician's Desk Reference) with the keyword, "GENDER". Results: There were descriptions related to gender in product directions of 361 drugs in 2009 PDR, out of which 63 items actually showed gender-related differences. Drug categories showing comparatively high gender-based differences were nervous system, cardiovascular system, and alimentary tract and metabolism. Pharmacokinetic differences between genders were observed most frequently; compared to men, 32 drugs showed higher absorption while 18 drugs revealed lower clearance in women. There were 2 drugs which gender should be considered before prescribing, and 5 drugs which showed different severity of adverse effects according to gender. Conclusions: It is necessary to establish domestic policies for drug approval and use which reflects gender-based differences through sufficient researches.
Keywords
Gender-based differences; Physician's Desk Reference; Drug approval;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Protecting and Advancing Women's Health: The FDA Office of Women's Health Progress Peport 10 years and Beyond…, Mar. 2006. http://www.fda.gov/womens/reports/report0306.pdf)
2 Guideline for Study and Evaluation of Gender Differences in the Clinical Evaluation of Drugs, Jul. 1993. (http://www.fda.gov)
3 Reflection Paper on Gender Differences in Cardiovascular Diseases, Dec. 2006. (http://www.emea.europa.eu)
4 PDR${\circledR}$ 63edition 2009.
5 Gail D. Gender differences in pharmacological response. Int Rev Neuro 2008; 83: 1-9.
6 Domecq C, Naranjo C, Ruiz I et al., Sex-related variations in the frequency and characteristics of adverse drug reactions. Int J Clin Pharmacol Ther 1980; 18: 362-6.
7 Mojaverian P, Rocci M, Vlasses P et al., Effect of Food on the absorption of enteric coated aspirin: Correlation with gastric residence time. Clin Pharmacol Ther 1987; 41: 11-7.   DOI   ScienceOn
8 Anderson G. Sex and racial differences in pharmacological response: Where is the evidence? Pharmacogenetics, and pharmacokinetics, and pharmacodynamics. J Womens Health 2005; 14: 19-29.   DOI   ScienceOn
9 Pepine CJ, Kerensky RA, Lambert CR, et al., Some thoughts on the vasculopathy of women with ischemic heart disease. J Am Coll Cardiol 2006; 47: S30-5.   DOI   ScienceOn
10 Yang X, Schadt EE, Wang S, et al., Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res 2006; 16: 995-1004.   DOI   ScienceOn
11 Society for Women's Health Research. (http://www.womenshealthresearch.org/site/PageServer?pagename =hs_sbb_10diff)
12 Cummins CL, Wu CY, Benet LZ. Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein. Clin Pharmacol Ther 2002; 72: 474-89.   DOI   ScienceOn
13 eNoteAlone. (http://www.enotalone.com/article/9085.html)
14 Ebert SN. Liu XK, Woosley RL. Female gender as a risk factor for drug-induced cardiac arrhythmias: evaluation of clinical and experimental evidence. J Womens Health 1998; 7: 547-57.   DOI   ScienceOn
15 Kim HJ, Choi JM, Kim YJ, et al., Review of gender differences in medicine and primary factors resulting in gender differences. Kor J Clin Pharm 2010; 20: 128-37.
16 Buckwalter J, Lappin D. The disproportionate impact of chronic arthralgia and arthritis among women. Clin Orthop Relat Res 2000; 372: 159-68.   DOI
17 Fattinger K, Roos M, Vergeres P, et al., Epidemiology of drug exposure and adverse drug reactions in two Swiss departments of internal medicine. Br J Clin Pharmacol 2000; 49: 158-67.
18 Tran C, Knowles S, R Liu, et al., Gender difference in adverse drug reactions. J Clin Pharmacol 1998; 38: 1003-9.   DOI
19 Gross J, Friedman R, Azevedo M, et al., Effect of age and sex on glomerular filtration rate measured by 51Cr-EDTA. Braz J Med Biol Res 1992; 25: 129-34.
20 Drici M, Clement N. Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome. Drug Saf 2001; 24: 575-85.   DOI   ScienceOn