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Economic Evaluation of Ramosetron in Male Patients with Diarrhea-predominant Irritable Bowel Syndrome in Korea  

Sohn, Hyun-Soon (College of Pharmacy, Sookmyung Women's University)
Lee, Tae-Jin (School of Public Health, Seoul National University)
Kim, Sun (School of Public Health, Seoul National University)
Publication Information
Korean Journal of Clinical Pharmacy / v.20, no.3, 2010 , pp. 268-277 More about this Journal
Abstract
This study was conducted to analyze the cost-utility of ramosetron monotherapy, trimebutine monotherapy and trimebutine+loperamide combination therapy in male diarrhea-predominant patients with irritable bowel syndrome (IBS) in Korean healthcare setting. We constructed a decision-analytical model to estimate both total costs for each state of health and outcomes such as IBS-symptoms improvement for 3 and 6 months time horizon. Base analysis found that for ramosetron treatment with the price of KW910 for 5 ${\mu}g$ tablet, incremental cost effectiveness ratios (ICERs, cost per quality-adjusted life day) were KW85,000 and KW62,000 for 3 months and 6 months, respectively, compared with trimebutine. But ramosetron was a dominant strategy when compared with trimebutine+loperamide for both 3 months and 6 months. Sensitivity analyses showed robust results for drug acquisition costs till ramosetron price of KW950/tablet. In conclusion, ramosetron was a cost-effective regimen compared with trimebutine or trimebutine+loperamide from the societal perspective.
Keywords
cost-utility; irritable bowel syndrome; ramosetron; trimebutine; loperamide;
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