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Pharmacokinetic Studies and Drug-drug Interactions of Herbal Medicine  

Jung, Won-Pill (College of Pharmacy, Catholic University of Daegu)
Noh, Keum-Han (College of Pharmacy, Catholic University of Daegu)
Lim, Mi-Sun (School of Medicine, Kyungpook National University)
Lee, Hae-Won (School of Medicine, Kyungpook National University)
Kim, Eun-Jung (Pharmacological Research Division, Korea Food & Drug Administration)
Yoon, Young-Ran (School of Medicine, Kyungpook National University)
Kang, Won-Ku (College of Pharmacy, Yeungnam University)
Publication Information
Korean Journal of Clinical Pharmacy / v.20, no.2, 2010 , pp. 99-106 More about this Journal
Abstract
Drugs mostly represent an efficacy or an adverse effect according to their dosage and/or plasma concentrations. Therefore, to investigate the pharmacokinetic behavior of drugs including herbal medicines is necessary both to maximize the drug action and to minimize the adverse effect. To date, pharmacokinetic studies of herbal medicines have been conducted by some experts in this field on the bases of science and knowledge in Korea. On the other hand, in advanced countries, a typical series of pharmacokinetic studies has been conducted by using a harmonized guidance established. Consequently, an administrative support on these studies has to be needed in Korea as well. This study aimed to establish a draft guidance on pharmacokinetic studies of herbal medicines in non-clinical and clinical studies. Literatures previously published as well as guidances in the US, Europe and Japan were summarized for the present guidance. Effect of herbal medicines was listed on the proteins in charge of drug metabolism and transportation, as well as on the pharmacokinetics of chemical drugs. The present suggestion might be helpful to proceed pharmacokinetic studies of herbal medicines efficiently, and further polish should be needed in terms of an administrative point of view.
Keywords
Herbal medicine; pharmacokinetics; guidance; drug-drug interactions;
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