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Retrospective Analysis of Adverse Reactions to Iodinated Contrast Media in Korean  

Kim, Hee Hyun (Department of Pharmacology, Inje University College of Medicine)
Choi, Ji Yeob (Department of Biomedical Sciences, Seoul National University College of Medicine)
Oh, Min Kyung (Department of Pharmacology, Inje University College of Medicine)
Kim, Eun Young (Department of Clinical pharmacology, Inje University Busanpaik Hospital)
Ghim, Jong Ryul (Department of Clinical pharmacology, Inje University Busanpaik Hospital)
Choi, Seok Jin (Department of Radiology, Inje University Busanpaik Hospital)
Shin, Jae Gook (Department of Pharmacology, Inje University College of Medicine)
Publication Information
Journal of Korean Society for Clinical Pharmacology and Therapeutics / v.20, no.2, 2012 , pp. 165-174 More about this Journal
Abstract
Background: This study was performed to evaluate the prevalence and risk factors on the adverse reactions caused by iodinated contrast media (CM) for computed tomography (CT) examination in a university hospital. Methods: Clinical and demographic data among outpatients with CM use were collected at 0000 University Busanpaik Hospital in Busan, Korea between 2008 and 2010. Adverse reaction rate was calculated by the number of adverse reaction among total outpatients with CM use, which was stratified by seasons and sex. The association of risk factors on adverse reaction was investigated using logistic regression model. Results: The total outpatients and events of administered CMs were 27,587 and 48,616, respectively. The administered CMs were iopromide, iohexol, iobitridol, and iodixanol. Adverse reactions occurred in 300 outpatients among the total outpatients (1.1 %). The number of outpatients administered CM more than twice were 8,348. Among them, outpatients who experienced adverse reaction(s) more than once and twice were 124 (1.5 %) and 26 (0.3 %), respectively. Adverse reaction rate was significantly different by sex(p=0.01). The other risk factors were cancer history (OR 2.57, 95 % CI 2.00-3.31) and previous CM administration (OR 1.89, 95 % CI 1.47-2.44). Urticaria was the most frequent symptoms. Conclusion: Total adverse reaction rate was 1.1 % with most common symptom in skin system. Related risk factors were female, cancer history, and previous CM administration. These results were similar to previous studies and will be contribute to clinical practice and future research especially in Koreans.
Keywords
Adverse reactions; Contrast media; Retrospective studies; Risk factors;
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1 Zukiwski AA, David CL, Coan J, Wallace S, Gutterman JU, Mavligit GM. Increased incidence of hypersensitivity to iodine-containing radiographic contrast media after interleukin-2 administration. Cancer, 1990;65(7):1521-1524.   DOI   ScienceOn
2 Munechika H, Hiramatsu Y, Kudo S, Sugimura K, Hamada C, Yamaguchi K, Katayama H. A prospective survey of delayed adverse reactions to iohexol in urography and computed tomography. Eur Radiol, 2003;13(1):185-194.   DOI
3 Brockow K, Romano A, Aberer W, Bircher AJ, Barbaud A, Bonadonna P, Faria E, Kanny G, Lerch M, Pichler WJ, Ring J, Rodrigues Cernadas J, Tomaz E, Demoly P, Christiansen C. Skin testing in patients with hypersensitivity reactions to iodinated contrast media - a European multicenter study. Allergy, 2009;64(2):234-241.   DOI   ScienceOn
4 Eloy R, Corot C, Belleville J. Contrast media for angiography: physicochemical properties. pharmacokinetics and biocompatibility. Clin Mater, 1991;7(2):89-197.   DOI
5 Dillman JR, Ellis JH, Cohan RH, Strouse PJ, Jan SC. Frequency and severity of acute allergic-like reactions to gadolinium-containing i.v. contrast media in children and adults. Am J Roentgenol, 2007;189(6):1533-1538.   DOI   ScienceOn
6 Bush WH, Swanson DP. Acute reactions to intravascular contrast media: types, risk factors, recognition, and specific treatment. Am J Roentgenol, 1991;157(6):1153-1161.   DOI   ScienceOn
7 Christiansen C. Late-onset allergy-like reactions to X-ray contrast media. Curr Opin Allergy Clin Immunol, 2002;2(4):333-339.   DOI   ScienceOn
8 Lieberman PL, Seigle RL. Reactions to radiocontrast material. Anaphylactoid events in radiology. Clin Rev Allergy Immunol, 1999; 17(4):469-496.   DOI   ScienceOn
9 Katayama H, Yamaguchi K, Kozuka T, Takashima T, Seez P, Matsuura K. Adverse reactions to ionic and nonionic contrast media. A report from the Japanese Committee on the Safety of Contrast Media. Radiology, 1990; 175(3):621-628.   DOI
10 Caro JJ, Trindade E, McGregor M. The risks of death and of severe nonfatal reactions with high- vs low-osmolality contrast media: a meta-analysis. Am J Roentgenol, 1991; 156(4): 825-832.   DOI   ScienceOn
11 Idee JM, Pines E, Prigent P, Corot C. Allergy -like reactions to iodinated contrast agents. A critical analysis. Fundam Clin Pharmacol, 2005;19(3):263-281.   DOI   ScienceOn
12 Lang DM, Alpern MB, Visintainer PF, Smith ST. Gender risk for anaphylactoid reaction to radiographic contrast media. J Allergy Clin Immunol, 1995;95(4):813-817.   DOI   ScienceOn
13 Singh J, Daftary A. Iodinated contrast media and their adverse reactions. J Nucl Med Technol, 2008;36(2):69-74.   DOI   ScienceOn
14 Shulman KL, Thompson JA, Benyunes MC, Winter TC, Fefer A. Adverse reactions to intravenous contrast media in patients treated with interleukin-2. J Immunother Emphasis Tumor Immunol, 1993;13(3):208-212.   DOI
15 Kopp AF, Mortele KJ, Cho YD, Palkowitsch P, Bettmann MA, Claussen CD. Prevalence of acute reactions to iopromide: postmarketing surveillance study of 74,717 patients. Acta Radiol, 2008;49(8):902-911.   DOI   ScienceOn
16 Petersein J, Peters CR, Wolf M, Hamm B. Results of the safety and efficacy of iobitridol in more than 61,000 patients. Eur Radiol, 2003;13(8):2006-2011.   DOI   ScienceOn
17 Kwon KS, Jeong JS. Analysis of Adverse Reactions to Computed Tomography Contrast Medium. Kor J Biol Nur Sci, 2004;6(2):57-68. (Korean)
18 Bush WH, Swanson DP. Radiocontrast. Immunol Allergy Clin North Am, 1995;15:597 -612.
19 Slater JE, Kaliner M. Effects of sex hormones on basophil histamine release in recurrent idiopathic anaphylaxis. J Allergy Clin Immunol, 1987;80(3 Pt 1):285-290.   DOI
20 Chernecky C. Documented allergies of patients with cancer. Eur J Cancer Care (Engl), 2003; 12(4):369-371.   DOI   ScienceOn
21 Thomson K, Varma D. Safe use of radiographic contrast media. Australian Prescriber, http: //www.australianprescriber.com/magazine/33/1/19/22/ [Online] (last visited on 22 Oct 2012).