Browse > Article

Inhibitory Effects of 6-Gingerol on Cytochrome P450 in Human Liver Microsomes  

Joo, Soo-Yeon (Department of Pharmacology, Chonnam National University Medical School)
Lim, Young-Chai (Department of Pharmacology, Chonnam National University Medical School)
Publication Information
Journal of Korean Society for Clinical Pharmacology and Therapeutics / v.19, no.1, 2011 , pp. 52-58 More about this Journal
Keywords
6-gingerol; Cytochrome P450; Inhibition; Human liver microsome;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Foti RS, Wahlstrom JL, Wienkers LC. The in vitro drug interaction potential of dietary supplements containing multiple herbal components. Drug Metab Dispos, 2007;35(2): 185-188.
2 Lin JH, Lu AYH. Inhibition and induction of cytochrome P450 and the clinical implications. Clin Pharmacokinet, 1998;35(5):361-390.   DOI   ScienceOn
3 Schmider J, von Moltke LL, Shader RI, Harmatz JS, Greenblatt DJ. Extrapolating in vitro data on drug metabolism to in vivo pharmacokinetics: evaluation of the pharmacokinetic interaction between amitriptyline and fluoxetine. Drug Metab Rev, 1999;31(2):545-560.   DOI   ScienceOn
4 Liu KH, Lee YM, Shon JH, Kim MJ, Lee SS, Yoon YR, Cha IJ, Shin JG. Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes. Xenobiotica, 2004;34(5):429-438.   DOI   ScienceOn
5 Dixon M. The determination of enzyme inhibitor constants. Biochemical J, 1953;55(1):170-171.   DOI
6 Guengerich FP, Shimada T, Yun CH, Yamazaki H, Raney KD, Thier R, Coles B, Harris TM. Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes. Environ Health Perspect, 1994; 102(Suppl 9):49-53.   DOI
7 Park KK, Chun KS, Lee JM, Lee SS, Surh YJ. Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer Lett, 1998;129(2):139-144.   DOI   ScienceOn
8 Guengerich FP. Human cytochrome P-450 enzymes. Life Sci, 1992;50(20):1471-1478.   DOI   ScienceOn
9 Gonzalez FJ. The molecular biology of cytochrome P450s. Pharmacol Rev, 1989;40(4): 243-288.
10 Kerremans ALM. Cytochrome P450 isoenzymes-importance for the internist. Neth J Med, 1996;48(6):237-243.   DOI   ScienceOn
11 Lee E, Surh YJ. Induction of apoptosis in HL -60 cells by pungent vanilloids, [6]-gingerol, and [6]-paradol. Cancer Lett, 1998;134(2):163-168.   DOI   ScienceOn
12 Masuda Y, Kikuzaki H, Hisamoto M, Nakatani N. Antioxidant properties of gingerol related compounds from ginger. Biofactors, 2004;21(1- 4):293-296.   DOI
13 Guh JH, Ko FN, Jong TT, Teng CM. Antiplatelet effects of gingerol isolated from Zingiber officinale. J Pharm Pharmacol, 1995;47(4):329-332.   DOI   ScienceOn
14 Aeschbach R, Loliger J, Scott BC, Murcia A, Butler J, Halliwell B, Aruoma Ol. Antioxidant actions of thymol, carbacrol, 6-gingerol, zingerone and hydroxytyrosol. Food Chem Toxicol, 1994;32(1):31-36.   DOI   ScienceOn
15 Sharma JN, Srivastava KC, Gan EK. Suppressive effects of eugenol and ginger oil on arthritis rats. Pharmacology, 1994;49(5):314-318.   DOI   ScienceOn
16 Srivastava KC, Mustafa T. Ginger (Zingiber officinale) and rheumatic disorders. Med Hypothesis, 1989;29(1):25-28.   DOI   ScienceOn