Comparison of Pharmacokinetics and Safety Between Coadministration of Cilostazol and Ginkgo Biloba Extract and Administration of a Fixed-Dose Combination
![]() |
Jeon, Hye-Won
(Department of Pharmacology and Clinical Pharmacology & Therapeutics, Seoul National University College of Medicine and Hospital)
Yi, So-Jeong (Department of Pharmacology and Clinical Pharmacology & Therapeutics, Seoul National University College of Medicine and Hospital) Kim, Sung-Eun (Department of Pharmacology and Clinical Pharmacology & Therapeutics, Seoul National University College of Medicine and Hospital) Kim, Bo-Hyung (Department of Pharmacology and Clinical Pharmacology & Therapeutics, Seoul National University College of Medicine and Hospital) Lim, Kyoung-Soo (Department of Pharmacology and Clinical Pharmacology & Therapeutics, Seoul National University College of Medicine and Hospital) Lee, Bong-Yong (Life Science R&D Center, SK Chemicals Co., Ltd) Yu, Kyung-Sang (Department of Pharmacology and Clinical Pharmacology & Therapeutics, Seoul National University College of Medicine and Hospital) Shin, Sang-Goo (Department of Pharmacology and Clinical Pharmacology & Therapeutics, Seoul National University College of Medicine and Hospital) Jang, In-Jin (Department of Pharmacology and Clinical Pharmacology & Therapeutics, Seoul National University College of Medicine and Hospital) |
1 | Igawa T, Tani T, Chijiwa T, Shiragiku, T, Shimidzu, S, Kawamura, K, Kato, S, Unemi, F, Kimura, Y. Potentiation of anti-platelet aggregating activity of cilostazol with vascular endothelial cells. Thromb Res, 1990;57:617-623. DOI ScienceOn |
2 | Chapman TM, Goa KL. Cilostazol: a review of its use in intermittent claudication. Am J Cardiovasc Drugs, 2003;3:117-138. DOI ScienceOn |
3 | Spinnewyn B, Blavet N, Clostre F, Bazan N, Braquet P. Involvement of platelet-activating factor (PAF) in cerebral post-ischemic phase in Mongolian gerbils. Prostaglandins, 1987;34:337-349. DOI ScienceOn |
4 | Kim TE, Kim BH, Kim J, Kim KP, Yi S, Shin HS, Lee YO, Lee KH, Shin SG, Jang IJ, Yu KS. Comparison of the pharmacokinetics of ticlopidine between administration of a combined fixed-dose tablet formulation of ticlopidine 250 mg/ginkgo extract 80 mg, and concomitant administration of ticlopidine 250-mg and ginkgo extract 80-mg tablets: an open-label, two-treatment, single-dose, randomized-sequence crossover study in healthy Korean male volunteers. Clin Ther, 2009;31:2249-2257. DOI ScienceOn |
5 | Multisource (generic) pharmaceutical products: guidelines on registration requirements to establish interchangeability. Geneva: WHO Technical Report Series, No. 937; 2006. |
6 | Birk S, Kruuse C, Petersen KA, Tfelt-Hansen P, Olesen J. The headache-inducing effect of cilostazol in human volunteers. Cephalalgia, 2006;26:1304-309. DOI ScienceOn |
7 | Ryu KH, Han HY, Lee SY, Jeon SD, Im GJ, Lee BY, Kim K, Lim KM, Chung JH. Ginkgo biloba extract enhances antiplatelet and antithrombotic effects of cilostazol without prolongation of bleeding time. Thromb Res, 2009;124:328-334. DOI ScienceOn |
8 | Bramer SL, Forbes WP, Mallikaarjun S. Cilostazol pharmacokinetics after single and multiple oral doses in healthy males and patients with intermittent claudication resulting from peripheral arterial disease. Clin Pharmacokinet, 1999;37 Suppl 2:1-11. DOI |
9 |
Pletal |
10 | Diamond BJ, Shiflett SC, Feiwel N, Matheis RJ, Noskin O, Richards JA, Schoenberger NE. Ginkgo biloba extract: mechanisms and clinical indications. Arch Phys Med Rehabil, 2000;81:668-678. |
11 | Guidelines for registration of fixed-dose combination medicinal products. Geneva: WHO Technical Report Series, No.929; 2005. |
12 | Kleijnen J, Knipschild P. Ginkgo biloba for cerebral insufficiency. Br J Clin Pharmacol, 1992;34:352-358. DOI ScienceOn |
13 | Jacobs BP, Browner WS. Ginkgo biloba: a living fossil. Am J Med, 2000;108:341-342. DOI ScienceOn |
14 | Birks J, Grimley EV, Van Dongen M. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev 2002:CD003120. |
![]() |