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http://dx.doi.org/10.22469/jkslp.2022.33.2.110

A Case of IgG4-Related Pseudotumor in Larynx  

Lee, Min Hyuk (Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Hong, Joon Pyo (Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Kim, Tae Hwan (Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Jin, Sung Min (Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
Publication Information
Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics / v.33, no.2, 2022 , pp. 110-114 More about this Journal
Abstract
IgG4-related disease is a fibroinflammatory condition by infiltration of IgG4-positive plasma cells that often presents as a tumorous lesion. This disease can affect nearly every organ system. After the pancreas, the head and neck region is second most common site for presentation of IgG4-related disease such as Mikulicz's disease, Küttner tumor. The involvement of IgG4-related disease in laryngeal lesions is extremely rare. We have experienced a case of IgG4-related disease with pseudotumor formation in the larynx that is suggestive of malignancy in radiologic findings. But the pathology findings was finally confirmed as IgG4-related disease. Oral treatment with prednisolone was initiated, and the edematous mass reduced in size without permanent functional impairment of vocal fold mobility. We report our experience with a literature review.
Keywords
Immunoglobulin G4-related disease; Larynx; Vocal cords;
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1 Behzadi F, Suh CH, Jo VY, Shanmugam V, Morgan EA, Guenette JP. Imaging of IgG4-related disease in the head and neck: A systematic review, case series, and pathophysiology update. J Neuroradiol 2021;48(5):369-78.   DOI
2 Yoon HJ, Park WS, Ji YB, Lee SH. Two cases of immunoglobulin G4-related sclerosing disease mimicking nasopharyngeal carcinoma. Korean J Otorhinolaryngol-Head Neck Surg 2016;59(4):304-8.   DOI
3 Mulholland GB, Jeffery CC, Satija P, Cote DW. Immunoglobulin G4-related diseases in the head and neck: A systematic review. J Otolaryngol Head Neck Surg 2015;44(1):24.   DOI
4 Shaib Y, Ton E, Goldschmeding R, Tekstra J. IgG4-related disease with atypical laryngeal presentation and Behcet/granulomatous polyangiitis mimicking features. BMJ Case Rep 2013;2013:bcr2013009158.
5 Khosroshahi A, Wallace ZS, Crowe JL, Akamizu T, Azumi A, Carruthers MN, et al. International consensus guidance statement on the management and treatment of IgG4-related disease. Arthritis Rheumatol 2015;67(7):1688-99.   DOI
6 Lee CM, Alalwani M, Prayson RA, Gota CE. Retrospective single-centre analysis of IgG4-related disease patient population and treatment outcomes between 2007 and 2017. Rheumatol Adv Pract 2019;3(1):rkz014.   DOI
7 Lanzillotta M, Mancuso G, Della-Torre E. Advances in the diagnosis and management of IgG4 related disease. BMJ 2020;369:m1067.   DOI
8 Shimizu Y, Yamamoto M, Naishiro Y, Sudoh G, Ishigami K, Yajima H, et al. Necessity of early intervention for IgG4-related disease--delayed treatment induces fibrosis progression. Rheumatology (Oxford) 2013;52:679-83.   DOI
9 Matsushima K, Ohira S, Matsui H, Fukuo A, Honma N, Wada K, et al. IgG4-related disease with pseudotumor formation in the larynx. Auris Nasus Larynx 2020;47(2):305-8.   DOI
10 Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 2001;344(10):732-8.   DOI
11 Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, et al. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol 2012;22(1):21-30.   DOI