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http://dx.doi.org/10.22469/jkslp.2022.33.1.13

Vocal Fold Leukoplakia: Updates in Diagnosis and Management  

Ji, Jeong-Yeon (Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine)
Kwon, Tack-Kyun (Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine)
Publication Information
Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics / v.33, no.1, 2022 , pp. 13-19 More about this Journal
Abstract
Vocal fold leukoplakia poses a challenge to otolaryngologists due to its various spectrum of pathologic diagnosis. The degree of dysplasia is associated with malignancy risk and the new 2017 WHO classification system changed from the 3-tier system to a 2-tier system consisting of low and high grades. Infections including candidiasis, cryptococcosis, and tuberculosis should also be included in the differential diagnosis. Efforts have been made to evaluate risks using endoscopic technologies such as narrow band imaging, and surgery is essential for histopathological diagnosis. Regarding management, it is important to make an accurate diagnosis and find a balance between oncologic safety and functional outcome.
Keywords
Vocal cords; Leukoplakia; Laryngeal disease; Precancerous conditions;
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1 Eckel HE, Simo R, Quer M, Odell E, Paleri V, Klussmann JP, et al. European Laryngological Society position paper on laryngeal dysplasia part II: Diagnosis, treatment, and follow-up. Eur Arch Otorhinolaryngol 2021;278(6):1723-32.   DOI
2 Cosway B, Paleri V. Laryngeal dysplasia: An evidence-based flow-chart to guide management and follow up. J Laryngol Otol 2015;129(6): 598-9.   DOI
3 Kono T, Saito K, Yabe H, Ogawa K. Phonosurgical resection using submucosal infusion technique for precancerous laryngeal leukoplakia. Laryngoscope 2017;127(1):153-8.   DOI
4 Benninger MS. Microdissection or microspot CO2 laser for limited vocal fold benign lesions: A prospective randomized trial. Laryngoscope 2000;110(2 Pt 2 Suppl 92):1-17.   DOI
5 Lim JY, Park YM, Kang M, Lee SJ, Baek K, Na J, et al. Angiolytic laser stripping versus CO2 laser microflap excision for vocal fold leukoplakia: Long-term disease control and voice outcomes. PLoS One 2018;13(12):e0209691.   DOI
6 Klimza H, Jackowska J, Tokarski M, Piersiala K, Wierzbicka M. Narrow-band imaging (NBI) for improving the assessment of vocal fold leukoplakia and overcoming the umbrella effect. PLoS One 2017;12(6):e0180590.   DOI
7 Pabuccuoglu U, Tuncer C, Sengiz S. Histopathology of candidal hyperplastic lesions of the larynx. Pathol Res Pract 2002;198(10):675-8.   DOI
8 McLaren KM, Burnett RA, Goodlad JR, Howatson SR, Lang S, Lee FD, et al. Consistency of histopathological reporting of laryngeal dysplasia. The Scottish Pathology Consistency Group. Histopathology 2000;37(5):460-3.   DOI
9 Kostev K, Jacob LEC, Kalder M, Sesterhenn AM, Seidel DU. Association of laryngeal cancer with vocal cord leukoplakia and associated risk factors in 1,184 patients diagnosed in otorhinolaryngology practices in Germany. Mol Clin Oncol 2018;8(5):689-93.
10 Lechien JR, Akst LM, Saussez S, Crevier-Buchman L, Hans S, Barillari MR, et al. Involvement of laryngopharyngeal reflux in select nonfunctional laryngeal diseases: A systematic review. Otolaryngol Head Neck Surg 2021;164(1):37-48.   DOI
11 Fleskens SA, Bergshoeff VE, Voogd AC, van Velthuysen ML, Bot FJ, Speel EJ, et al. Interobserver variability of laryngeal mucosal premalignant lesions: A histopathological evaluation. Mod Pathol 2011;24(7):892-8.   DOI
12 Gale N, Poljak M, Zidar N. Update from the 4th edition of the World Health Organization classification of head and neck tumours: What is new in the 2017 WHO blue book for tumours of the hypopharynx, larynx, trachea and parapharyngeal space. Head Neck Pathol 2017;11(1):23-32.   DOI
13 Weller MD, Nankivell PC, McConkey C, Paleri V, Mehanna HM. The risk and interval to malignancy of patients with laryngeal dysplasia; a systematic review of case series and meta-analysis. Clin Otolaryngol 2010;35(5):364-72.   DOI
14 Gale N, Zidar N, Poljak M, Cardesa A. Current views and perspectives on classification of squamous intraepithelial lesions of the head and neck. Head Neck Pathol 2014;8(1):16-23.   DOI
15 Gumussoy M, Kucuk U. Candidiasis causing vocal fold leukoplakia: Review of clinical and pathological results of 289 cases with vocal fold leukoplakia. Ann Otol Rhinol Laryngol 2019;128(10):903-10.   DOI
16 Piazza C, Cocco D, De Benedetto L, Del Bon F, Nicolai P, Peretti G. Narrow band imaging and high definition television in the assessment of laryngeal cancer: A prospective study on 279 patients. Eur Arch Otorhinolaryngol 2010;267(3):409-14.   DOI
17 Fang TJ, Lin WN, Lee LY, Young CK, Lee LA, Chang KP, et al. Classification of vocal fold leukoplakia by clinical scoring. Head Neck 2016;38 Suppl 1:E1998-2003.   DOI
18 Lou ZC, Li X. Leukoplakia or LPR: The misdiagnosis of laryngeal tuberculosis. Ear Nose Throat J 2021;100(5_suppl):549S-53.   DOI
19 Rzepakowska A, Sobol M, Sielska-Badurek E, Niemczyk K, Osuch-Wojcikiewicz E. Morphology, vibratory function, and vascular pattern for predicting malignancy in vocal fold leukoplakia. J Voice 2020;34(5):812.e9-e15.   DOI
20 Klimza H, Pietruszewska W, Rosiak O, Morawska J, Nogal P, Wierzbicka M. Leukoplakia: An invasive cancer hidden within the vocal folds. A multivariate analysis of risk factors. Front Oncol 2021;11:772255.   DOI
21 Djukic V, Milovanovic J, Jotic AD, Vukasinovic M. Stroboscopy in detection of laryngeal dysplasia effectiveness and limitations. J Voice 2014;28(2):262.e13-e21.   DOI
22 Arens C, Piazza C, Andrea M, Dikkers FG, Tjon Pian Gi RE, Voigt-Zimmermann S, et al. Proposal for a descriptive guideline of vascular changes in lesions of the vocal folds by the committee on endoscopic laryngeal imaging of the European Laryngological Society. Eur Arch Otorhinolaryngol 2016;273(5):1207-14.   DOI
23 Piazza C, Cocco D, Del Bon F, Mangili S, Nicolai P, Peretti G. Narrow band imaging and high definition television in the endoscopic evaluation of upper aero-digestive tract cancer. Acta Otorhinolaryngol Ital 2011;31(2):70-5.
24 Montgomery J, White A. A decade of laryngeal dysplasia in Paisley, Scotland. Eur Arch Otorhinolaryngol 2012;269(3):947-51.   DOI
25 van Balkum M, Buijs B, Donselaar EJ, Erkelens DC, Goulin Lippi Fernandes E, Wegner I, et al. Systematic review of the diagnostic value of laryngeal stroboscopy in excluding early glottic carcinoma. Clin Otolaryngol 2017;42(1):123-30.   DOI
26 Cikojevic D, Gluncic I, Pesutic-Pisac V. Comparison of contact endoscopy and frozen section histopathology in the intra-operative diagnosis of laryngeal pathology. J Laryngol Otol 2008;122(8):836-9.   DOI
27 Cohen JT, Safadi A, Fliss DM, Gil Z, Horowitz G. Reliability of a transnasal flexible fiberoptic in-office laryngeal biopsy. JAMA Otolaryngol Head Neck Surg 2013;139(4):341-5.   DOI
28 Richards AL, Sugumaran M, Aviv JE, Woo P, Altman KW. The utility of office-based biopsy for laryngopharyngeal lesions: comparison with surgical evaluation. Laryngoscope 2015;125(4):909-12.   DOI
29 Bouquot J. Oral cancers with leukoplakia. Oral Dis 1999;5(3):183-4.   DOI
30 Park JC, Altman KW, Prasad VMN, Broadhurst M, Akst LM. Laryngeal leukoplakia: State of the art review. Otolaryngol Head Neck Surg 2021;164(6):1153-9.   DOI
31 van Hulst AM, Kroon W, van der Linden ES, Nagtzaam L, Ottenhof SR, Wegner I, et al. Grade of dysplasia and malignant transformation in adults with premalignant laryngeal lesions. Head Neck 2016;38 Suppl 1:E2284-90.   DOI
32 Dispenza F, De Stefano A, Marchese D, Martines F, Dispenza C. Management of laryngeal precancerous lesions. Auris Nasus Larynx 2012;39(3):280-3.   DOI
33 Gale N, Gnepp DR, Poljak M, Strojan P, Cardesa A, Helliwell T, et al. Laryngeal squamous intraepithelial lesions: An updated review on etiology, classification, molecular changes, and treatment. Adv Anat Pathol 2016;23(2):84-91.   DOI
34 Peretti G, Piazza C, Berlucchi M, Cappiello J, Giudice M, Nicolai P. Pre- and intraoperative assessment of mid-cord erythroleukoplakias: A prospective study on 52 patients. Eur Arch Otorhinolaryngol 2003;260(10):525-8.   DOI
35 Ni XG, He S, Xu ZG, Gao L, Lu N, Yuan Z, et al. Endoscopic diagnosis of laryngeal cancer and precancerous lesions by narrow band imaging. J Laryngol Otol 2011;125(3):288-96.   DOI
36 Broadhurst MS, Akst LM, Burns JA, Kobler JB, Heaton JT, Anderson RR, et al. Effects of 532 nm pulsed-KTP laser parameters on vessel ablation in the avian chorioallantoic membrane: Implications for vocal fold mucosa. Laryngoscope 2007;117(2):220-5.   DOI
37 Shoffel-Havakuk H, Sadoughi B, Sulica L, Johns MM 3rd. In-office procedures for the treatment of benign vocal fold lesions in the awake patient: A contemporary review. Laryngoscope 2019;129(9):2131-8.   DOI
38 Lukes P, Zabrodsky M, Lukesova E, Chovanec M, Astl J, Betka JA, et al. The role of NBI HDTV magnifying endoscopy in the prehistologic diagnosis of laryngeal papillomatosis and spinocellular cancer. Biomed Res Int 2014;2014:285486.   DOI
39 Isenberg JS, Crozier DL, Dailey SH. Institutional and comprehensive review of laryngeal leukoplakia. Ann Otol Rhinol Laryngol 2008;117(1):74-9.   DOI
40 Kim CM, Chhetri DK. Triological best practice: When is surgical intervention indicated for vocal fold leukoplakia? Laryngoscope 2020;130(6):1362-3.   DOI
41 Klimza H, Jackowska J, Piazza C, Banaszewski J, Wierzbicka M. The role of intraoperative narrow-band imaging in transoral laser microsurgery for early and moderately advanced glottic cancer. Braz J Otorhinolaryngol 2019;85(2):228-36.   DOI
42 Stanikova L, Walderova R, Jancatova D, Formanek M, Zelenik K, Kominek P. Comparison of narrow band imaging and the Storz Professional Image Enhancement System for detection of laryngeal and hypopharyngeal pathologies. Eur Arch Otorhinolaryngol 2018;275(7):1819-25.   DOI
43 Worrall DM, Lerner DK, Naunheim MR, Woo P. Laryngeal cryptococcosis: An evolving rare clinical entity. Ann Otol Rhinol Laryngol 2019;128(5):472-9.   DOI
44 Saraniti C, Chianetta E, Greco G, Mat Lazim N, Verro B. The impact of narrow-band imaging on the pre-and intra-operative assessments of neoplastic and preneoplastic laryngeal lesions. A systematic review. Int Arch Otorhinolaryngol 2021;25(3):e471-8.   DOI
45 Karatayli-Ozgursoy S, Pacheco-Lopez P, Hillel AT, Best SR, Bishop JA, Akst LM. Laryngeal dysplasia, demographics, and treatment: A single-institution, 20-year review. JAMA Otolaryngol Head Neck Surg 2015;141(4):313-8.   DOI
46 Sarioglu S, Cakalagaoglu F, Elagoz S, Han U, Etit D, Hucumenoglu S, et al. Inter-observer agreement in laryngeal pre-neoplastic lesions. Head Neck Pathol 2010;4(4):276-80.   DOI
47 Sifrer R, Sereg-Bahar M, Gale N, Hocevar-Boltezar I. The diagnostic value of perpendicular vascular patterns of vocal cords defined by narrow-band imaging. Eur Arch Otorhinolaryngol 2020;277(6):1715-23.   DOI