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CT Fluoroscopy-Guided Core Biopsy for Diagnosis of Small ($\leq$ 20 mm) Pulmonary Nodules  

Lee, Hye-Larn (Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine)
Kim, Yoon-Kyung (Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine)
Woo, Ok-Hee (Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine)
Yong, Hwan-Seok (Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine)
Kang, Eun-Young (Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine)
Kim, Hyun-Koo (Department of Thoracic Surgery, Korea University Guro Hospital, Korea University College of Medicine)
Shin, Bong-Kyung (Department of Pathology, Korea University Guro Hospital, Korea University College of Medicine)
Publication Information
Journal of the Korean Society of Radiology / v.65, no.4, 2011 , pp. 373-379 More about this Journal
Abstract
Purpose: To evaluate the efficacy of CT fluoroscopy-guided core biopsy of small pulmonary nodules. Materials and Methods: This study included 62 patients (35 men, 27 women; age range, 36-85 years) that had a small ($\leq$ 20 mm) pulmonary nodule and underwent CT fluoroscopy-guided core biopsy. The overall diagnostic accuracy and complication rate were calculated. The diagnostic accuracy was compared between two groups according to the nodule size ($\leq$ 10 mm vs. > 10 mm), and nodule density (solid vs. subsolid). Results: Malignant or premalignant lesions were finally diagnosed in 39 patients; 36 true-positive and three false-negative findings (sensitivity, 92%). A benign lesion was finally diagnosed in 23 patients, with no false-positive results (specificity, 100%). The overall diagnostic accuracy was 95%. The sensitivity and diagnostic accuracy were 85% and 91% for nodules $\leq$ 10 mm, and 96% and 97% for nodules > 10 mm (p > 0.05). The sensitivity and diagnostic accuracy were 93% and 96% in the solid group and 90% and 92% in the subsolid group (p > 0.05). Seventeen (27%) patients had a pneumothorax and two (3%) required a closed thoracostomy. Conclusion: CT fluoroscopy-guided core biopsy of small pulmonary nodules yields high diagnostic accuracy with acceptable complication rates.
Keywords
Computed Tomography; Computed Tomography Fluoroscopy; Biopsy, Needle; Lung Neoplasms; Pulmonary Nodules;
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