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Short-Term Catheter-Directed Thrombolysis with Low-Dose Urokinase Followed by Aspiration Thrombectomy for Treatment of Symptomatic Lower Extremity Deep Venous Thrombosis  

Jung, Se-Hee (Department of Radiology, Chonnam National University Hospital)
Kim, Jae-Kyu (Department of Radiology, Chonnam National University Hospital)
Chang, Nam-Kyu (Department of Radiology, Chonnam National University Medical School)
Lim, Jae-Hoon (Department of Radiology, Chonnam National University Hospital)
Lim, Nam-Yeul (Department of Radiology, Chonnam National University Hospital)
Song, Jang-Hyeon (Department of Radiology, Chonnam National University Hospital)
Choi, Soo-Jin-Na (Department of Surgery, Chonnam National University Hospital, Chonnam National University Medical School)
Chung, Sang-Young (Department of Surgery, Chonnam National University Hospital, Chonnam National University Medical School)
Publication Information
Journal of the Korean Society of Radiology / v.65, no.4, 2011 , pp. 337-344 More about this Journal
Abstract
Purpose: To evaluate the venous patency in patients treated by catheter-directed thrombolysis with low-dose urokinase (UK) for symptomatic lower extremity deep venous thrombosis (DVT). Materials and Methods: Eighty-nine consecutive patients (46 women and 43 men; mean age, 58.1 years), treated by catheter-directed thrombolysis with low-dose UK were included in this study. Immediate venous patency was evaluated in terms of technical success (successful restoration of antegrade in-line flow in the treated vein with residual stenosis rate of less than 30%) and clinical success (significant reduction of clinical symptoms before hospital discharge). Late venous patency was evaluated in terms of primary patency rate and clinical success. Results: Immediate technical success was achieved in all patients and immediate clinical success in 80 (90%) patients. There was no major systemic bleeding complication. The primary patency rate at 6 months and 12 months was 84% and 79%, respectively. Fifty-six (63%) patients were asymptomatic after a median clinical follow-up of 18 months, eleven (12%) patients improved moderately, seven (8%) patients remained unchanged, and fifteen (17%) patients had no clinical follow-up. Conclusion: Short-term catheter-directed thrombolysis with low-dose UK can be an effective, safe method to manage DVT of the lower extremities.
Keywords
Catheter-Directed Thrombolysis; Aspiration Thrombectomy; Lower Extremity Deep Venous Thrombosis;
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