Browse > Article

Feasibility of Endovascular Radiation Therapy Using Holmium-166 Filled Balloon Catheter in a Swine Hemodialysis Fistula Model: Preliminary Results  

Won, Jong-Yun (Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine)
Lee, Kwang-Hun (Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine)
Lee, Do-Yun (Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine)
Kim, Myoung-Soo (Department of Surgery, Yonsei University College of Medicine)
Kang, Byung-Chul (Department of Radiology, School of Medicine, Ewha Woman's University)
Kim, Seung-Jung (Department of Internal Medicine, School of Medicine, Ewha Woman's University)
Publication Information
Journal of the Korean Society of Radiology / v.65, no.2, 2011 , pp. 119-125 More about this Journal
Abstract
Purpose: To describe how to make a swine hemodialysis fistula model and report our initial experience to test the feasibility of endovascular radiation therapy with Holmium-166 filled balloon catheters. Materials and Methods: The surgical formation of arterio-venous fistula (AVF) was performed by end-to-side anastomosis of the bilateral jugular vein and carotid artery of 6 pigs. After 4 weeks, angiograms were taken and endovascular radiation was delivered to the venous side of AVF with Holmium-166 filled balloon catheters. Pigs were sacrificed 4 weeks after the radiation and AVFs were harvested for histological examination. Results: All animals survived without any morbidity during the experimental periods. The formation of fistula on the sides of necks was successful in 11 of the 12 pigs (92%). One AVF failed from the small jugular vein. On angiograms, 4 of the 11 AVFs showed total occlusion or significant stenosis and therefore, endovascular radiation could not be performed. Of 7 eligible AVFs, five underwent successful endovascular radiation and two AVFs did not undergo radiation for the control. Upon histologic analysis, one non-radiated AVF showed total occlusion and others showed intimal thickening from the neointimal hyperplasia. Conclusion: Formation of the swine carotid artery-jugular vein hemodialysis fistula model was successful. Endovascular radiation using a Holmium-166 filled balloon catheter was safe and feasible.
Keywords
Arteriovenous Fistula; Brachytherapy; Holmium; Radiotherapy; Swine;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Diskin CJ. Pharmacologic intervention to prevent hemodialysis vascular access thrombosis: the next generation of treatment? Kidney Int 2005;67:2505
2 Windus DW. Permanent vascular access: a nephrologist's view. Am J Kidney Dis 1993;21:457-471   DOI
3 Masaki T, Rathi R, Zentner G, Leypoldt JK, Mohammad SF, Burns GL, et al. Inhibition of neointimal hyperplasia in vascular grafts by sustained perivascular delivery of paclitaxel. Kidney Int 2004;66:2061-2069   DOI   ScienceOn
4 Quinn SF, Schuman ES, Demlow TA, Standage BA, Ragsdale JW, Green GS, et al. Percutaneous transluminal angioplasty versus endovascular stent placement in the treatment of venous stenoses in patients undergoing hemodialysis: intermediate results. J Vasc Interv Radiol 1995;6:851-855   DOI   ScienceOn
5 Sarac TP, Riggs PN, Williams JP, Feins RH, Baggs R, Rubin P, et al. The effects of low-dose radiation on neointimal hyperplasia. J Vasc Surg 1995;22:17-24   DOI   ScienceOn
6 Teirstein PS, Massullo V, Jani S, Russo RJ, Cloutier DA, Schatz RA, et al. Two-year follow-up after catheter-based radiotherapy to inhibit coronary restenosis. Circulation 1999;99:243-247   DOI   ScienceOn
7 Liermann DD, Bauernsachs R, Schopohl B, Böttcher HD. Five year follow-up after brachytherapy for restenosis in peripheral arteries. Semin Interv Cardiol 1997;2:133-137
8 Johnson MS, McLennan G, Lalka SG, Whitfield RM, Dreesen RG. The porcine hemodialysis access model. J Vasc Interv Radiol 2001;12:969-977   DOI   ScienceOn
9 Trerotola SO, Carmody TJ, Timmerman RD, Bergan KA, Dreesen RG, Frost SV, et al. Brachytherapy for the prevention of stenosis in a canine hemodialysis graft model: preliminary observations. Radiology 1999;212:748-754   DOI
10 Popma JJ, Suntharalingam M, Lansky AJ, Heuser RR, Speiser B, Teirstein PS, et al. Randomized trial of 90Sr/90Y beta-radiation versus placebo control for treatment of in-stent restenosis. Circulation 2002;106:1090-1096   DOI   ScienceOn
11 Grise MA, Massullo V, Jani S, Popma JJ, Russo RJ, Schatz RA, et al. Five-year clinical follow-up after intracoronary radiation: results of a randomized clinical trial. Circulation 2002;105:2737-2740   DOI   ScienceOn
12 Joh CW, Park CH, Kang HJ, Oh YT, Chun, Kim HS, et al. Measurement of radiation absorbed dose in endovascular Ho-166 brachytherapy using a balloon angio-catheter. Nucl Med Commun 2000;21:959-964   DOI   ScienceOn
13 Kanterman RY, Vesely TM, Pilgram TK, Guy BW, Windus DW, Picus D. Dialysis access grafts: anatomic location of venous stenosis and results of angioplasty. Radiology 1995;195:135-139
14 Roy-Chaudhury P, Kelly BS, Narayana A, Desai P, Melhem M, Munda R, et al. Hemodialysis vascular access dysfunction from basic biology to clinical intervention. Adv Ren Replace Ther 2002;9:74-84   DOI   ScienceOn
15 Kim SJ, Masaki T, Leypoldt JK, Kamerath CD, Mohammad SF, Cheung AK. Arterial and venous smooth-muscle cells differ in their responses to antiproliferative drugs. J Lab Clin Med 2004;144:156-162   DOI   ScienceOn
16 Rodriguez VM, Grove J, Yelich S, Pearson D, Stein M, Pevec WC. Effects of brachytherapy on intimal hyperplasia in arteriovenous fistulas in a porcine model. J Vasc Interv Radiol 2002;13:1239-1246   DOI   ScienceOn
17 Malhotra S, Teirstein PS. The SCRIPPS trial--catheter-based radiotherapy to inhibit coronary restenosis. J Invasive Cardiol 2000;12:330-332
18 Kim HS, Cho YH, Kim JS, Oh YT, Kang HJ, Chun MS, et al. Effect of transcatheter endovascular radiation with holmium-166 on neointimal formation after balloon injury in porcine coronary artery. J Nucl Cardiol 2000;7:478-483   DOI   ScienceOn
19 King SB 3rd, Williams DO, Chougule P, Klein JL, Waksman R, Hilstead R, et al. Endovascular beta-radiation to reduce restenosis after coronary balloon angioplasty: results of the beta energy restenosis trial (BERT). Circulation 1998;97:2025-2030   DOI   ScienceOn
20 Waksman R, Robinson KA, Crocker IR, Gravanis MB, Cipolla GD, King SB 3rd. Endovascular low-dose irradiation inhibits neointima formation after coronary artery balloon injury in swine. A possible role for radiation therapy in restenosis prevention. Circulation 1995;91:1533-1539   DOI   ScienceOn
21 Badal A, Kyprianou I, Badano A, Sempau J. Monte Carlo simulation of a realistic anatomical phantom described by triangle meshes: application to prostate brachytherapy imaging. Radiother Oncol 2008;86:99-103   DOI   ScienceOn
22 Kwok CS, Prestwich WV, Wilson BC. Calculation of radiation doses for nonuniformity distributed beta and gamma radionuclides in soft tissue. Med Phys 1985;12:405-412   DOI   ScienceOn
23 Kim JH, Lee JT, Kim EK, Won JY, Kim MJ, Lee JD, et al. Percutaneous sclerotherapy of renal cysts with a beta-emitting radionuclide, holmium-166-chitosan complex. Korean J Radiol 2004;5:128-133   DOI   ScienceOn