Browse > Article

Real-Time US Diagnosis for Perithyroidal Invasion of Thyroid Malignancy  

Heo, Young-Jin (Department of Radiology, Busan Paik Hospital, Inje University School of Medicine)
Kim, Dong-Wook (Department of Radiology, Busan Paik Hospital, Inje University School of Medicine)
Publication Information
Journal of the Korean Society of Radiology / v.65, no.1, 2011 , pp. 13-17 More about this Journal
Abstract
Purpose: To assess the diagnostic accuracy of real-time ultrasound (US) for perithyroidal invasion of thyroid malignancy. Materials and Methods: From January 2009 to December 2009, real-time US was performed on malignant thyroid nodules (largest diameter ${\geq}$ 10 mm) located in the isthmus or attached to the adjacent tracheal wall, by a single radiologist who prospectively determined the presence or absence of perithyroidal invasion. Results: Of the 60 malignant thyroid nodules examined, intraglandular location (n = 0), capsular attachment with clear perithyroidal fat (n = 15), perithyroidal fat infiltration without tracheal invasion (n = 43), and tracheal invasion (n = 2) were prospectively determined. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of real-time US diagnosis for perithyroidal invasion were 80%, 90%, 94.1%, 69.2% and 83.3%, respectively when the pathological result was used as reference standard. Real-time US accuracies for intraglandular location, capsular attachment with clear perithyroidal fat, perithyroidal fat infiltration without tracheal invasion, and tracheal invasion were 76.6%, 53.3%, 51.7%, and 85.0%, respectively. Conclusion: The results of the real-time US diagnoses indicate that this method may be useful for diagnosing perithyroidal invasion of thyroid malignancies. Hence, further research is needed to prove the use of diagnosing perithyroidal invasion of thyroid malignancies.
Keywords
Thyroid Nodule; Thyroid Neoplasm; Ultrasonography; Neoplasm Invasiveness; Real-Time;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kim EK, Park CS, Chung WY, Oh KK, Kim DI, Lee JT, et al. New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid. AJR Am J Roentgenol 2002;178:687-691   DOI   ScienceOn
2 Moon WJ, Baek JH, Jung SL, Kim DW, Kim EK, Kim JY, et al. Ultrasonography and the ultrasound-based management of thyroid nodules: consensus statement and recommendations. Korean J Radiol 2011;12:1-14   DOI   ScienceOn
3 Frates MC, Benson CB, Doubilet PM, Kunreuther E, Contreras M, Cibas ES, et al. Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. J Clin Endocrinol Metab 2006;91: 3411-3417   DOI   ScienceOn
4 Koike E, Noguchi S, Yamashita H, Murakami T, Ohshima A, Kawamoto H, et al. Ultrasonographic characteristics of thyroid nodules: prediction of malignancy. Arch Surg 2001;136:334-337   DOI   ScienceOn
5 Park JS, Son KR, Na DG, Kim E, Kim S. Performance of preoperative sonographic staging of papillary thyroid carcinoma based on the sixth edition of the AJCC/UICC TNM classification system. AJR Am J Roentgenol 2009;192:66-72   DOI   ScienceOn
6 Stulak JM, Grant CS, Farley DR, Thompson GB, van Heerden JA, Hay ID, et al. Value of preoperative ultrasonography in the surgical management of initial and reoperative papillary thyroid cancer. Arch Surg 2006;141:489-494; discussion 494-496   DOI
7 Kouvaraki MA, Shapiro SE, Fornage BD, Edeiken-Monro BS, Sherman SI, Vassilopoulou-Sellin R, et al. Role of preoperative ultrasonography in the surgical management of patients with thyroid cancer. Surgery 2003;134:946-954; discussion 954-955   DOI   ScienceOn
8 Tomoda C, Uruno T, Takamura Y, Ito Y, Miya A, Kobayashi K, et al. Ultrasonography as a method of screening for tracheal invasion by papillary thyroid cancer. Surg Today 2005;35:819-822
9 Wang JC, Takashima S, Takayama F, Kawakami S, Saito A, Matsushita T, et al. Tracheal invasion by thyroid carcinoma: prediction using MR imaging. AJR Am J Roentgenol 2001;177:929-936   DOI   ScienceOn
10 Shaha AR. TNM classification of thyroid carcinoma. World J Surg 2007;31:879-887   DOI   ScienceOn
11 Greene FL, Page DL, Fleming ID, Fritz AG, Balch CM, Haller DG, et al. AJCC cancer staging handbook: TNM classification of malignant tumors, 6th ed. New York, NY: Springer-Verlag, 2002
12 Yang CC, Lee CH, Wang LS, Huang BS, Hsu WH, Huang MH. Resectional treatment for thyroid cancer with tracheal invasion: a long-term follow-up study. Arch Surg 2000;135:704-707   DOI   ScienceOn
13 Koshiishi H, Toriya K, Ozaki O, Ito K, Konaka C, Kato H. Fiberoptic bronchoscopy in thyroid carcinoma with tracheal invasion. Diagn Ther Endosc 1998;4:113-118   DOI   ScienceOn
14 Koike E, Yamashita H, Noguchi S, Yamashita H, Ohshima A, Watanabe S, et al. Bronchoscopic diagnosis of thyroid cancer with laryngotracheal invasion. Arch Surg 2001;136: 1185-1189   DOI   ScienceOn
15 Cobin RH, Gharib H, Bergman DA, Clark OH, Cooper DS, Daniels GH, et al. AACE/AAES medical/surgical guidelines for clinical practice: management of thyroid carcinoma. American Association of Clinical Endocrinologists. American College of Endocrinology. Endocr Pract 2001;7:202-220   DOI
16 Yamamura N, Fukushima S, Nakao K, Nakahara M, Kurozumi K, Imabun S, et al. Relation between ultrasonographic and histologic findings of tracheal invasion by differentiated thyroid cancer. World J Surg 2002;26:1071-1073   DOI   ScienceOn