Browse > Article

Acute Cerebral Infarction after FK 506 Administration in a Kidney Transplantation Recipient: A Case Report  

Lim, Ji-Kyung (Department of Diagnostic Radiology, College of Medicine, Yeungnam University)
Byun, Woo-Mok (Department of Diagnostic Radiology, College of Medicine, Yeungnam University)
Kim, Jae-Woon (Department of Diagnostic Radiology, College of Medicine, Yeungnam University)
Publication Information
Journal of the Korean Society of Radiology / v.64, no.2, 2011 , pp. 109-112 More about this Journal
Abstract
FK506 is widely used as a potent immunosuppressive agent following organ transplantation. However, the use of FK506 is associated with a wide spectrum of neurotoxicity.F K506-induced cerebral infarctions have rarely been reported. We report here on a case of the acute cerebral infarction caused by vasospasm after FK506 administration in a kidney transplantation recipient. There were areas with increased signal intensity on the diffusion-weighted image. The areas showing increased signal intensity on the diffusion- and $T_2$-weighted images demonstrated decreased signal intensity on the apparent diffusion coefficient mapping. MR angiography showed diffuse stenosis in both the anterior and middle cerebral arteries.
Keywords
Tacrolimus; Neurotoxicity Syndrome; Stroke; Kidney Transplantation; Neurotoxins;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Gijtenbeek JM, van den Bent MJ, Vecht CJ. Cyclosporine neurotoxicity: a review. J Neurol 1999;246:339-346   DOI   ScienceOn
2 Basic-Jukic N, Basic-Kes V, Kes P, Furic-Cunko V, Bacic-Baronica K. Neurological complications in renal transplant recipients. Acta Med Croatica 2008;62 Suppl 1:76-81
3 Ahn KJ, Lee JW, Hahn ST, Yang DW, Kim PS, Kim HJ, et al. Diffusion-weighted MRI and ADC mapping in FK506 neurotoxicity. Br J Radiol 2003;76:916-919   DOI   ScienceOn
4 Kinoshita T, Moritani T, Shrier DA, Hiwatashi A, Wang HZ, Numaguchi Y, et al. Diffusion-weighted MR imaging of posterior reversible leukoencephalopathy syndrome: a pictorial essay. Clin Imaging 2003;27:307-315   DOI   ScienceOn
5 Keenan RJ, Konishi H, Kawai A, Paradis IL, Nunley DR, Iacono AT, et al. Clinical trial of tacrolimus versus cyclosporine in lung transplantation. Ann Thorac Surg 1995;60:580-584   DOI   ScienceOn
6 Eidelman BH, Abu-Elmagd K, Wilson J, Fung JJ, Alessiani M, Jain A, et al. Neurologic complications of FK 506. Transplant Proc 1991;23:3175-3178
7 Junna MR, Rabinstein AA. Tacrolimus induced leukoencephalopathy presenting with status epilepticus and prolonged coma. J Neurol Neurosurg Psychiatry 2007;78:1410-1411   DOI   ScienceOn
8 Kilinc M, Benli S, Can U, Yilmaz A, Karakayali H, Colak T, et al. FK 506-induced fulminant leukoencephalopathy after kidney transplantation: case report. Transplant Proc 2002;34:1182-1184   DOI   ScienceOn
9 Curro G, Baccarani U, Adani GL, Lorenzin D, Bresadola F. Transient ischemic attack after rizatriptan administration in a liver transplant recipient: a case report. Transplant Proc 2006;38:3138-3139   DOI   ScienceOn