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Modified Classification of MRI Findings to Predict Histologic Grading of Liposarcomas  

Moon, Tae-Yong (Department of Radiology, School of Medicine, Pusan National University)
Lee, In-Sook (Department of Radiology, School of Medicine, Pusan National University)
Hwang, In-Kyung (Department of Preventive Medicine, School of Medicine, Pusan National University)
Yang, Ik (Department of Radiology, Hallym University Kangnam Sacred Heart Hospital)
Lee, Sun-Joo (Department of Radiology, Inje University Baik Hospital)
Choi, Yoon-Young (Department of Radiology, School of Medicine, Pusan National University)
Publication Information
Journal of the Korean Society of Radiology / v.63, no.2, 2010 , pp. 177-183 More about this Journal
Abstract
Purpose: To predict the histopathologic grading of liposarcomas with the modified classification of MRI findings. Materials and Methods: The 47 MRI studies of pathologically confirmed liposarcomas were retrospectively analyzed, and found to have well-differentiated (n=17) and myxoid (n=16) types, representing the 'low grade' sarcomas, as well as the round cell (n=9) and pleomorphic (n=5) types, which represent the 'high grade' sarcomas. The MRI findings of liposarcomas were classified into four groups as the one with fat signal above 80%, 20-80%, below 20%, and no fat signal on T1-weighted images (WIs), into three groups as the one with high signals with reticular or irregular lines, homogeneous above 50% of the area, and heterogeneous above 50% on the T2WIs, and into three groups as the one enhanced with reticular or irregular lines and enhancement areas above 50% and below 50% on the Gd-DTPA T1WIs. Results: The sarcomas with a lower amount of fat signals on T1WIs had a significantly higher histologic grade (p = 0.026) and also showed heterogeneous high signals above 50% on the T2WIs was statistically significant difference (p = 0.010) but not on the contrast enhanced T1WIs (p = 0.070). Conclusion: The modified classification of the MR findings could help predict the histologic grading of liposarcomas.
Keywords
Liposarcoma; Soft Tissue Neoplasms; Magnetic Resonance Imaging; Classification;
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1 Kransdorf MJ, Bancroft LW, Peterson JJ, Murphey MD, Foster WC, Temple HT. Imaging of fatty tumors: distinction of lipoma and well-differentiated liposarcoma. Radiology 2002;224:99-104   DOI   ScienceOn
2 Sung MS, Kang HS, Suh JS, Lee JH, Park JM, Kim JY, et al. Myxoid liposarcoma: appearance at MR imaging with histologic correlation. Radiographics 2000;20:1007-1019
3 Enzinger FM, Weiss SW. Soft tissue tumors. 2nd ed. St Louis: Mosby, 1988:346-382
4 Song T, Shen J, Liang BL, Mai WW, Li Y, Guo HC. Retroperitoneal liposarcoma: MR characteristics and pathological correlative analysis. Abdom Imaging 2007;32:668-674   DOI   ScienceOn
5 Baur A, Bartl R, Pellengahr C, Baltin V, Peiser M. Neovascularization of bone marrow in patients with diffuse multi-ple myeloma. Cancer 2004;101:2599-2604   DOI   ScienceOn
6 문태용, 이인숙, 이지원, 김정일, 최경운, 김원택. 290예 연조직종 양의 자기공명 해부조직학적 분포. 대한영상의학회지 2008;59:417-427
7 Kim JI, Choi KU, Lee IS, Moon TY, Lee CH, Kim HW, et al. Gene expression in mixed type liposarcoma. Pathology 2006;38:114-119   DOI   ScienceOn
8 Reszel PA, Soule EH, Coventry MB. Liposarcoma of the extremities and limb girdles: a study of 222 cases. J Bone Joint Surg Am 1966;48:229-244   DOI
9 Kransdorf MJ. Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR Am J Roentgenol 1995;164:129-134   DOI   ScienceOn
10 Jelinek JS, Kransdorf MJ, Shmookler BM, Aboulafia AJ, Malawer MM. Liposarcoma of the extremities: MR and CT findings in the histologic subtypes. Radiology 1993;186:455-459   DOI
11 Fletcher CD, Unni KK, Mertens F. Pathology and genetics of tumours of soft tissue and bone. Lyon, France: IARC, 2002
12 Tateishi U, Hasegawa T, Beppu Y, Kawai A, Satake M, Moriyama N. Prognostic significance of MRI findings in patients with myxoid- round cell liposarcoma. AJR Am J Roentgenol 2004;182:725-731   DOI   ScienceOn
13 Arkun R, Memis A, Akalin T, Ustun EE, Sabah D, Kandiloglu G. Liposarcoma of soft tissue: MRI findings with pathologic correlation. Skeletal Radiol 1997;26:167-172   DOI   ScienceOn
14 Kransdorf MJ, Moser RP, Meis JM, Meyer CA. Fat containing soft tissue masses of the extremities. Radiographics 1991;11:81-106
15 Wu JS, Hochman MG. Soft-tissue tumors and tumorlike lesions: a systematic imaging approach. Radiology 2009;253:297-316   DOI   ScienceOn
16 Orson GG, Sim FH, Reiman HM, Taylor WF. Liposarcoma of the musculoskeletal system. Cancer 1987;60:1362-1270   DOI   ScienceOn