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http://dx.doi.org/10.3349/ymj.2012.53.2.401

Herpes Simplex Virus 2 Infection Rate and Necessity of Screening during Pregnancy: A Clinical and Seroepidemiologic Study  

Kim, Il Dong (Department of Obstetrics and Gynecology, Grace Women's Hospital)
Chang, Ho Sun (Department of Obstetrics and Gynecology, Grace Women's Hospital)
Hwang, Kyung Jin (Department of Obstetrics and Gynecology, Grace Women's Hospital)
Publication Information
Yonsei Medical Journal / v.53, no.2, 2012 , pp. 401-407 More about this Journal
Abstract
Purpose: This study determined the seroprevalence of herpes virus 2 in gravidas and the differences between herpes virus 2-infected and healthy gravidas. The need to screen gravidas for herpes virus 2 was also evaluated. Materials and Methods: A retrospective analysis involving 500 gravidas who underwent herpes virus 2 serologic testing and delivery in our hospital between January 2009 and August 2010 was performed. All patients in the study group were classified as herpes simplex virus 2 (HSV2) positive, and all cases were analyzed with respect to the clinical course of the pregnancy, pregnancy outcome, obstetric complications, and neonatal outcomes. SPSS software (version 14.0) was used for statistical analysis. A chi-square test and Student's t-test were used for statistical analysis. Results: In the current study, the herpes virus 2 seroprevalence rate in gravidas was 17%. There was no significant difference in the rates of preterm delivery, premature rupture of membranes, preterm labor, and intrauterine growth restriction between the herpes virus 2-infected gravidas and the healthy control group. The rates of spontaneous abortion and sexually transmitted disease were higher in the herpes virus 2 infection group than the healthy control group. Conclusion: After educating gravidas on genital herpes and, if gravidas thereafter consent to herpes virus 2 screening, the risk of neonatal herpes virus 2 infections can be reduced. In addition, examination of gravidas for sexually transmitted diseases would increase as would appropriate treatment.
Keywords
Herpes virus 2; seroprevalence; pregnancy; sexually transmitted disease;
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