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http://dx.doi.org/10.15616/BSL.2022.28.3.145

Applications of MALDI-TOF Mass Spectrometry in Clinical Microbiology  

Shin, Kyeong Seob (Department of Laboratory M edicine, Chungbuk National University College of Medicine)
Yum, Jonghwa (Department of Clinical Laboratory Science, Dongeui University)
Publication Information
Biomedical Science Letters / v.28, no.3, 2022 , pp. 145-156 More about this Journal
Abstract
Over the past few decades, few technologies have had a greater impact on clinical microbiology laboratories than matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF MS). The MALDI-TOF MS is a fast, accurate, and low-cost and efficient method of microbial identification. This technology generates characteristic mass spectral fingerprints that is a unique signature for each microorganism, making it an ideal method for accurate identification at the genus and species levels of both bacterial and fastidious microorganism such as anaerobes, mycobacterium and fungi etc. In addition, MALDI-TOF MS has been successfully used in microbial subtyping and susceptibility tests such as determination of resistance genes. In this study, the authors summarized the application of MALDI-TOF MS in clinical microbiology and clinical research and explored the future of MALDI-TOF MS.
Keywords
MALDI-TOF MS; Clinical microbiology; Application; Identification; Subtyping; Susceptibility;
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