Browse > Article
http://dx.doi.org/10.15616/BSL.2022.28.2.137

Analgesic Effect of Poria cocos Extract on a Rat Model of Adjuvant-induced Arthritis  

Lee, Gil-Hyun (Department of Clinical Laboratory Science, Wonkwang Health Science University)
Yoon, Hae-Gyung (Division of Basic Science, Dong-Eui University)
Choi, Go-Eun (Department of Clinical Laboratory Science, Catholic University of Pusan)
Hyun, Kyung-Yae (Department of Clinical Laboratory Science, Dong-Eui University)
Publication Information
Biomedical Science Letters / v.28, no.2, 2022 , pp. 137-144 More about this Journal
Abstract
Poria cocos is a natural substance known to have anticancer, antioxidant and anti-inflammatory effects. The aim of this study is to investigate the analgesic effects of Poria cocos extract (PCE). We evaluated the analgesic effects of PCE using adjuvant induced arthritis rat model. Male SD rats were administered intra-orally with PCE according to prescribed dosage, during 6 days. After 6 days later, serum TNF-α, IL-1β, and IL-6 levels were measured by ELISA. In our experiment, administration of PCE decreased TNF-α, IL-1β, IL-6 and PGE2 level in serum. Furthermore, it was confirmed that allodynia was relieved in evaluation of pain behavior. It was confirmed that administration of PCE reduces nociceptive pain by reducing nociceptive stimuli by acting as an anti-inflammatory drug.
Keywords
Poria cocos; Adjuvant; Pain; Nociceptive pain; TNF-${\alpha}$; IL-$1{\beta}$; IL-6;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Oyaizu M. Studies on products of browning reaction antioxidative activities of products of browning reaction prepared from glucosamine. The Japanese Journal of Nutrition and Dietetics. 1986. 44: 307-315.   DOI
2 Saban-Ruiz J, Alonso-Pacho A, Fabregate-Fuente M, Gonzalez-Quevedo C. Xanthine oxidase inhibitor febuxostat as a novel agent postulated to act against vascular inflammation. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 2013. 12: 94-99.   DOI
3 Schaible HG, Richter F. Pathophysiology of pain. Langenbeck's Archives of Surgery. 2004. 389: 237-243.
4 Shin YJ, Kim KS, Park GS. Texture and sensory characteristics of fish paste containing white Poria cocos wolf powder. Korean Journal of Food and Cookery Science. 2009. 25: 119-125.
5 Chen YY, Chang HM. Antiproliferative and differentiating effects of polysaccharide fraction from fu-ling (Poria cocos) on human leukemic U937 and HL-60 cells." Food and Chemical Toxicology. 2004: 42.5: 759-769.   DOI
6 Kedare SB, Singh RP. Genesis and development of dpph method of antioxidant assay. Journal of Food Science and Technology. 2011. 48: 412-422.   DOI
7 Ferreira IC, Baptista P, Vilas-Boas M, Barros L. Free-radical scavenging capacity and reducing power of wild edible mushrooms from northeast portugal: Individual cap and stipe activity. Food Chemistry. 2007. 100: 1511-1516.   DOI
8 Ferreira S, Lorenzetti B, Poole S. Bradykinin initiates cytokine-mediated inflammatory hyperalgesia. British Journal of Pharmacology. 1993. 110: 1227.   DOI
9 George J, Struthers AD. Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress. Vascular Health and Risk Management. 2009. 5: 265.   DOI
10 Lambert GA, Mallos G, Zagami AS. Von frey's hairs-a review of their technology and use-a novel automated von frey device for improved testing for hyperalgesia. Journal of Neuroscience Methods. 2009. 177: 420-426.   DOI
11 Woolf CJ. Central sensitization: Implications for the diagnosis and treatment of pain. Pain. 2011. 152: S2-S15.   DOI
12 Simon JP, Evan Prince S. Natural remedies for non-steroidal anti-inflammatory drug-induced toxicity. Journal of Applied Toxicology. 2017. 37: 71-83.   DOI
13 Song YS, Kim SH, Sa JH, Jin C, Lim CJ, Park EH. Anti-angiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom phellinus linteus. Journal of Ethnopharmacology. 2003. 88: 113-116.   DOI
14 Wang N, Zhang Y, Wang X, Huang X, Fei Y, Yu Y, Shou D. Antioxidant property of water-soluble polysaccharides from Poria cocos wolf using different extraction methods. Journal of Ethnopharmacology. 2016. 83: 103-110.
15 Wu K, Fan J, Huang X, Wu X, Guo C. Hepatoprotective effects exerted by Poria cocos polysaccharides against acetaminopheninduced liver injury in mice. International Journal of Biological Macromolecules. 2018. 114: 137-142.   DOI
16 Wu SJ, Ng LT, Lin CC. Antioxidant activities of some common ingredients of traditional chinese medicine, angelica sinensis, lycium barbarum and Poria cocos. Phytotherapy Research. 2004. 18: 1008-1012.   DOI
17 Embuscado ME. Spices and herbs: Natural sources of antioxidants-a mini review. Journal of Functional Foods. 2015. 18: 811-819.   DOI
18 Molyneux P. The use of the stable free radical dpph for estimating antioxidant activity. J Sci. 2004. 26: 211-219.
19 Pardutz A, Schoenen J. Nsaids in the acute treatment of migraine: A review of clinical and experimental data. Pharmaceuticals. 2010. 3: 1966-1987.   DOI
20 Sandkuhler J. Models and mechanisms of hyperalgesia and allodynia. Physiological Reviews. 2009. 89: 707-758.   DOI
21 Mittal M, Siddiqui MR, Tran K, Reddy SP, Malik AB. Reactive oxygen species in inflammation and tissue injury. Antioxidants & Redox Signaling. 2014. 20: 1126-1167.   DOI
22 Zhang W, Chen L, Li P, Zhao J, Duan J. Antidepressant and immunosuppressive activities of two polysaccharides from Poria cocos (schw.) wolf. Journal of Biological Macromolecules. 2018. 120: 1696-1704.   DOI
23 KS J, Ramesh C, Srinivasa T, Raghu KL. Comparative studies on dpph and reducing power antioxidant properties in aqueous extracts of some common fruits. Journal of Pharmacy Research. 2010. 3: 2378-2380.
24 Choi SH, Lee SJ, Jo WS, Choi JW, Park SC. Comparison of ingredients and antioxidant activity of the domestic regional Wolfiporia extensa. The Korean Journal of Mycology. 2016. 44: 23-30.   DOI
25 RuiDian K, ShunFa L, Yi C, ChuRong J, QiaGuang S. Analysis of chemical composition of polysaccharides from Poria cocos wolf and its anti-tumor activity by NMR spectroscopy. Carbohydrate Polymers. 2010. 80: 31-34.   DOI
26 Jang YA, Lee JT. The evaluation of antioxidant, anti-inflammatory, and anti-aging of extract solvent and Poria cocos by parts. Kor J Aesthet Cosmetol. 2015. 13: 377-383.
27 Jeong JW, Lee HH, Han MH, Kim GY, Hong SH, Park C, Choi YH, Medicine A. Ethanol extract of Poria cocos reduces the production of inflammatory mediators by suppressing the nfkappab signaling pathway in lipopolysaccharide-stimulated raw 264.7 macrophages. Complementary and Alternative Medicine. 2014. 14: 1-8.   DOI
28 Hunt SP, Mantyh PW. The molecular dynamics of pain control. Nature Reviews Neuroscience. 2001. 2: 83-91.   DOI
29 Kim HO, Lee SI. Experimental animal models for rheumatoid arthritis: Methods and Applications. Journal of Rheumatic Diseases. 2012. 19: 189-195.   DOI
30 Lee S, Lee D, Lee SO, Ryu JY, Choi SZ, Kang KS, Kim KH. Anti-inflammatory activity of the sclerotia of edible fungus, Poria cocos wolf and their active lanostane triterpenoids. Journal of Functional Foods. 2017. 32: 27-36.   DOI
31 Newaz MA, Adeeb NNN. Detection of xanthine oxidase in human plasma. Medical Journal of Malaysi. 1998. 53: 70-75.