Browse > Article
http://dx.doi.org/10.15616/BSL.2021.27.1.12

Association of PPARGC1A Gene Variants with Hypertension in Korean Population  

Jin, Hyun-Seok (Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University)
Park, Sangwook (Department of Biomedical Laboratory Science, College of Health and Medical Science, Sangji University)
Publication Information
Biomedical Science Letters / v.27, no.1, 2021 , pp. 12-18 More about this Journal
Abstract
Hypertension (HTN) is one of the cardiovascular disease risk factors. Peroxisome proliferator-activated receptor γ coactivator 1 alpha (PPARGC1A) is involved in a master modulator of mitochondrial biogenesis, and pulmonary arterial hypertension. In this study, we report results of PPARGC1A were associated with hypertension and its intermediate phenotype of systolic (SBP) and diastolic blood pressure (DBP) in the Korean population. In detail, identifying a susceptibility locus, 3 SNPs for HTN, 2 SNPs for SBP, 3 SNPs for DBP at P<0.05. Among them, rs1472095 in PPARGC1A gene statistically demonstrated one of the significant correlations with Hypertension (P-value=0.00359, OR=0.8, 95% CI=0.68~0.93). The minor allele (T) of PPARGC1A was statistically associated with the increased value of DBP, SBP, and the increase risk of hypertension. We aim to manifest a significant association between genetic variant in PPARGC1A and hypertension. This finding suggested that association of PPARGC1A genetic polymorphism and HTN accelerates our understanding of blood pressure control and underlines potential drug targets for treatment of hypertension.
Keywords
DBP; Hypertension; PPARGC1A; SBP;
Citations & Related Records
연도 인용수 순위
  • Reference
1 El Rouby N, McDonough CW, Gong Y, McClure LA, Mitchell BD, Horenstein RB, et al. Genome-wide association analysis of common genetic variants of resistant hypertension. Pharmacogenomics J. 2019. 19: 295-304.   DOI
2 Healthcare Bigdata, and Health Insurance Review & Assessment Service, 2019 http://opendata.hira.or.kr/op/opc/olapMfrnIntrsIlnsInfo.do
3 Ingelsson E, Bennet L, Ridderstrale M, Soderstrom M, Rastam L, Lindblad U. The PPARGC1A Gly482Ser polymorphism is associated with left ventricular diastolic dysfunction in men. BMC Cardiovasc Disord. 2008. 8: 37.   DOI
4 Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005. 365: 217-223.   DOI
5 Li TT, Tan TB, Hou HQ, Zhao XY. Changes in peroxisome proliferatoractivated receptor alpha target gene expression in peripheral blood mononuclear cells associated with non-alcoholic fatty liver disease. Lipids Health Dis. 2018.17: 256.   DOI
6 Marcus JH, Novembre J. Visualizing the geography of genetic variants. Bioinformatics. 2017. 33: 594-595.   DOI
7 Martinez-Redondo V, Pettersson AT, Ruas JL. The hitchhiker's guide to PGC-1alpha isoform structure and biological functions. Diabetologia. 2015. 58: 1969-1977.   DOI
8 Ahmetov II, Fedotovskaya ON. Current Progress in Sports Genomics. Adv Clin Chem. 2015. 70: 247-314.   DOI
9 Cabrera CP, Ng FL, Nicholls HL, Gupta A, Barnes MR, Munroe PB, et al. Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated. Hum Mol Genet. 2019. 21; 28: R151-R161.
10 Pan S, Naruse H, Nakayama T. Progress and issues of the genome-wide association study for hypertension. Curr Med Chem. 2015. 22: 1016-1029.   DOI
11 Petr M, Maciejewska-Skrendo A, Zajac A, Chycki J, Stastny P. Association of Elite Sports Status with Gene Variants of Peroxisome Proliferator Activated Receptors and Their Transcriptional Coactivator. Int J Mol Sci. 2019. 21: 162.   DOI
12 Popov DV. Adaptation of Skeletal Muscles to Contractile Activity of Varying Duration and Intensity: The Role of PGC-1α. Biochemistry (Mosc). 2018. 83: 613-628.   DOI
13 Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998. 92: 829-839.   DOI
14 Qiu L, Fan X, Zhang Y, Teng X, Miao Y. Molecular characterization, tissue expression and polymorphisms of buffalo PPARGC1A gene. Arch Anim Breed. 2020. 63: 249-259.   DOI
15 Singh M, Singh AK, Pandey P, Chandra S, Singh KA, Gambhir IS. Molecular genetics of essential hypertension. Clinical and Experimental Hypertension. 2016. 38: 268-277.   DOI
16 Sinha RA, Rajak S, Singh BK, Yen PM. Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk. Int J Mol Sci. 2020. 21: 2391.   DOI
17 World Health Organization. A Global Brief on Hypertension: Silent Killer, Global Public Health Crisis. Geneva, Switzerland: World Health Organization, 2013.
18 Vargas-Sanchez K, Vargas L, Urrutia Y, Beltran I, Rossi AB, Lozano HY, et al. PPARα and PPARβ/δ are negatively correlated with proinflammatory markers in leukocytes of an obese pediatric population. J Inflamm (Lond). 2020. 17: 35.   DOI
19 Vimaleswaran KS, Luan J, Andersen G, Muller YL, Wheeler E, Brito EC, et al. The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis involving 13,949 individuals. J Appl Physiol (1985). 2008. 105:1352-1358.   DOI
20 Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, et al. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet. 2017. 49: 403-415.   DOI
21 Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, Ban HJ, et al. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet. 2009. 41: 527-534.   DOI
22 Yeligar SM, Kang BY, Bijli KM, Kleinhenz JM, Murphy TC, Torres G, et al. PPARγ Regulates Mitochondrial Structure and Function and Human Pulmonary Artery Smooth Muscle Cell Proliferation. Am J Respir Cell Mol Biol. 2018. 58: 648-657.   DOI
23 Carretero OA, Oparil S. Essential hypertension. Part I: definition and etiology. Circulation. 2000. 101: 329-335.   DOI