Browse > Article
http://dx.doi.org/10.15616/BSL.2020.26.2.85

Anti-inflammatory Effect of Flower Bud and Fruit of Sweet Persimmon, Diospyros kaki T.  

Park, Yeo Ok (Department of Biohealth Sciences, College of Natural Sciences, Changwon National University)
Lee, Jeong Ah (Department of Biohealth Sciences, College of Natural Sciences, Changwon National University)
Park, Seong Moon (Department of Biohealth Sciences, College of Natural Sciences, Changwon National University)
Ha, Min Hee (Department of Biohealth Sciences, College of Natural Sciences, Changwon National University)
Joo, Woo Hong (Department of Biology and Chemistry, College of Natural Sciences, Changwon National University)
Kim, Dong Wan (Department of Biohealth Sciences, College of Natural Sciences, Changwon National University)
Publication Information
Biomedical Science Letters / v.26, no.2, 2020 , pp. 85-92 More about this Journal
Abstract
Various beneficial effects of sweet persimmon (Diospyros kaki T.) including anti-oxidation, anti-bacteria and viruses, anti-allergy were widely reported previously. However, the anti-inflammatory effect and its molecular mechanisms are not clear. In this study, the anti-inflammatory effect of the extracts of flower bud and fruit of sweet persimmon was investigated in LPS-treated RAW264.7 cells. Both extracts of flower bud and fruit showed strong inhibitory effect on the LPS-induced NF-κB activation. IκBα, the inhibitor of NF-κB, was increased and the expressions of NF-κB target genes, COX-2 and iNOS, were suppressed by the treatment with the extracts of flower bud and fruit. The expressions of pro-inflammatory cytokines, IL-1β, IL-6, TNF-α were also suppressed by the extracts. In addition, the LPS-induced wnt/β-catenin pathway and its related gene expressions including cyclin D1, wnt 3a, wnt 5a were suppressed by the extracts. The extracts also showed anti-oxidant activity and suppressive effect on the LPS-induced apoptosis of RAW264.7 cells. These results suggest that the flower bud and fruit of sweet persimmon display strong anti-inflammatory effect through inhibiting the pro-inflammatory signaling pathways in the cells.
Keywords
Sweet persimmon; Anti-inflammatory; NF-${\kappa}B$; $Wnt/{\beta}$-catenin; Anti-oxidant;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Achiwa Y, Hibasmi H, Katsuzaki H, Iami K, Komiya T. Inhibitory effects of persimmon (Diospyros kaki) extract and related polyphenol compounds on growth of human lymphoid leukemicells. Biosci Biothchnol Biochem. 1997. 61: 1099-1101.   DOI
2 Ben-Neriah Y, Karin M. Inflammation meets cancer, with NFkappaB as the matchmaker. Nat Immunol. 2011. 12: 715-723.   DOI
3 Choi JH, Lee EY, Kim GJ, Park IH, Kim JS, Choi GB, Jung SG, Ham YS. Physicochemical properties and physiological activities of Ulsan sweet persimmon peel . flesh according to cultivars. J Korean Soc Appl Biol Chem. 2006. 49: 309-314.
4 Clevers H, Nusse R. Wnt/beta-catenin signaling and disease. Cell. 2012. 149: 1192-1205.   DOI
5 George AP, Redpath S. Health and medicinal benefits of persimmon fruit: a review. Adv Hort Sci. 2008. 22: 244-249.
6 Kawase M, Motohashi N, Satoh K, Sakagami H, Nakashima H, Tani S, Shirataki Y, Kurihara T, Spengler G, Wolfard K, Molnar J. Biological activity of persimmon (Diospyros kaki) peel extracts. Phytotheraphy Res. 2003. 17: 495-500.   DOI
7 Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011. 144: 646-674.   DOI
8 Jang J, Ha JH, Chung SI, Yoon Y. Beta-catenin regulates NFkappaB activity and inflammatory cytokine expression in bronchial epithelial cells treated with lipopolysaccharide. Int J Mol Med. 2014. 34: 632-638.   DOI
9 Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of $NF-{\kappa}B$ activity. Annu Rev Immunol. 2000. 18: 621-663.   DOI
10 Kotani M, Matsumoto M, Fujita A, Higa S, Wang W, Suemura M, Kishimoto T, Tanaka T. Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J Allergy Clin Immunol. 2000. 106: 159-166.   DOI
11 Kuprash DV, Nedospasov SA. Molecular and cellular mechanisms of inflammation. Biochemistry (Moscow). 2016. 81: 1237-1239.   DOI
12 Lee JS, Lee MK, Ha TY, Bok SH, Park HM, Jeong KS, Woo MN, Do GM, Yeo JY, Choi MS. Supplementation of whole persimmon leaf improves lipid profiles and suppresses body weight gain in rats fed high-fat diet. Food Chem Toxicol. 2006. 44: 1875-1883.   DOI
13 Moparthi L, Koch S. Wnt signaling in intestinal inflammation. Differentiation. 2019. 108: 24-32.   DOI
14 Lee SJ, Ryu JH, Kim RJ, Lee HJ, Sung NJ. Effect of removed peel from sweet persimmon on nutritional ingredients and antioxidant activities. J Korean Soc Food Sci Nutr. 2010. 39: 1495-1502.   DOI
15 Lei L, Wan G, Han B, Zhang Z. Echinacoside alleviated LPSinduced cell apoptosis and inflammation in rat intestine epithelial cells by inhibiting the mTOR/STAT3 pathway. Biomedicine & Pharmacotherapy. 2018. 104: 622-628.   DOI
16 Li X, Gou C, Yang H, Qiu J, Gu T, Wen T. Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation. Scand J Gastroenterol. 2014. 49: 993-1000.   DOI
17 Ma B, Hottiger MO. Crosstalk between $wnt/{\beta}$-catenin and $NF-{\kappa}B$ signaling pathway during inflammation. Front Immunol. 2016. 7: 378.   DOI
18 Mittal M, Siddiqui MR, Tran K, Reddy SP, Malik AB. Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal. 2014. 20: 1126-1167.   DOI
19 Naik E, Dixit VM. Mitochondrial reactive oxygen species drive proinflammatory cytokine production. J Exp Med. 2011. 208: 417-420.   DOI
20 Sartor RB. Pathogenesis and immune mechanisms of chronic inflammatory bowel disease. Am J Gastroenterol. 1997. 92: 5S-11S
21 Song HS, Lee HK, Kang MH. Antimutagenic effects of persimmon leaf tea extract (PLTE) in mice using micro-nucleus induction (MN) test. J Korean Soc Food Sci Nutr. 2000. 29: 881-887.
22 Symmons DP. Epidemiology research in rheumatology - progress and pitfalls. Nat Rev Rheumatol. 2015. 11: 631-638.   DOI
23 You DH, Jang IC, Seo GU, Kim SJ, Yang EK, Ahn GH, Matsushita Y, Fukushima K, Lee SC. Antioxidant activity of branches of fuyu and nishimurawase persimmon trees. J Appl Biol Chem. 2010. 53: 82-86.   DOI
24 Li C, Xu MM, Wang K, Adler AJ, Vella AT, Zhou B. Macrophage polarization and Meta-inflammation. Transl Res. 2018. 191: 29-44.   DOI
25 Tak PP, Firestein GS. NF-kappaB: a key role in inflammatory disease. J Clin Invest. 2001. 107: 7-11.   DOI
26 Uchida S, Nishioka I, Niwa M, Ozaki M. Condensed tannins scavenge active oxygen free radical. Med Sci Res. 1987. 15: 831-835.
27 Villar J, Cabrera NE, Casula M, Valladares F, Flores C, Lopez-Aguilar J, Blanch L, Zhang H, Kacmarek RM, Slutsky AS. $wnt/{\beta}$-catenin signaling is modulated by mechanical ventilation in an experimental model of acute lung injury. Intensive Care Med. 2011. 37: 1201-1209.   DOI
28 Xi Y, Huang X, Tan G, Chu X, Zhang R, Ma X, Ni B, You H. Protective effects of Erdosteine on interleukin-$1{\beta}$-stimulated inflammation via inhibiting the activation of MAPK, $NF-{\kappa}B$, and $wnt/{\beta}$-catenin signaling pathways in rat osteoarthritis. European J Pharmacol. 2020. 873: 172925.   DOI