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http://dx.doi.org/10.15616/BSL.2019.25.1.7

A Comparative Study of [F-18] Florbetaben (FBB) PET Imaging, Pathology, and Cognition between Normal and Alzheimer Transgenic Mice  

Thapa, Ngeemasara (Department of Health care and Science, College of Health Sciences, Dong-A University)
Jeong, Young-Jin (Department of Nuclear Medicine, Dong-A University Medical Center, Dong-A University College of Medicine)
Kang, Hyeon (Institute of Convergence Bio-Health, Dong-A University)
Choi, Go-Eun (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan)
Yoon, Hyun-Jin (Department of Nuclear Medicine, Dong-A University Medical Center, Dong-A University College of Medicine)
Kang, Do-Young (Department of Nuclear Medicine, Dong-A University Medical Center, Dong-A University College of Medicine)
Publication Information
Biomedical Science Letters / v.25, no.1, 2019 , pp. 7-14 More about this Journal
Abstract
Alzheimer's disease (AD) is highly prevalent in dementia, with no specifically effective treatment having yet been discovered. Amyloid plaques are one of the key hallmarks of AD. Transgenic mouse models exhibiting Alzheimer's disease-like pathology have been widely used to study the pathophysiology of Alzheimer's disease. In this study, we showed an age-dependent correlation between cognitive function, pathological findings, and [F-18] Florbetaben (FBB) PET images. Nineteen transgenic mice (12 with AD, 7 with controls) were used for this study. We observed an increase in ${\beta}$-Amyloid deposition ($A{\beta}$) in brain tissue and [F-18] FBB amyloid PET imaging in the AD group. The [F-18] FBB data showed a mildly negative trend with cognitive function. Pathological findings were negatively correlated with cognitive functions. These finding suggests that amyloid beta deposition can be well-monitored with [F-18] FBB PET and a decline in cognitive function is related to the increase in amyloid plaque burden.
Keywords
[F-18] FBB; Tg2576 mouse; Alzheimer's disease; ${\beta}$-Amyloid; PET imaging;
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