Browse > Article
http://dx.doi.org/10.15616/BSL.2015.21.3.160

Short-term Hypothermia Induces Beta-catenin-interacting Protein 1 Gene Expression in PC12 Cells  

Kwon, Kisang (Department of Biomedical Laboratory Science, College of Health & Welfare, Kyungwoon University)
Yoo, Bo-Kyung (Department of Anatomy, College of Medicine, Chungnam National University)
Lee, Eun Ryeong (Department of Biomedical Laboratory Science, College of Health & Welfare, Kyungwoon University)
Kim, Seung-Whan (Department of Emergency Medicine, Chungnam National University Hospital)
Yu, Kweon (Korea Research Institute of Bioscience & Biotechnology)
Kwon, O-Yu (Department of Anatomy, College of Medicine, Chungnam National University)
Publication Information
Biomedical Science Letters / v.21, no.3, 2015 , pp. 160-163 More about this Journal
Abstract
The effects of hypothermic treatment ($32^{\circ}C$) on recovery from ischemia are controversial because the precise mechanisms of hypothermia remain unclear. We demonstrated previously that hypothermia induces beta-catenin-interacting protein 1 (CTNNBIP1) gene expression in vitro. In this study, we evaluated the effects of various hypothermic conditions, including lithium chloride treatment, on CTNNBIP1 gene expression. The results show that short-term hypothermic treatment resulted in relatively higher CTNNBIP1 gene expression than that of a longer treatment. These findings indicate that hypothermia controls CTNNBIP1 gene expression, which may provide clues to develop treatments to recover from and diagnose ischemia.
Keywords
Hypothermia; Beta-catenin-interacting protein 1 (CTNNBIP1); PC12 cells;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Cruciat CM. Casein kinase 1 and Wnt/${\beta}$-catenin signaling. Curr Opin Cell Biol. 2014. 31: 46-55.   DOI
2 Darwazeh R, Yan Y. Mild hypothermia as a treatment for central nervous system injuries: Positive or negative effects. Neural Regen Res. 2013. 8: 2677-2686.
3 Holowacz T, Huelsken J, Dufort D, van der Kooy D. Neural stem cells are increased after loss of ${\beta}$-catenin, but neural pro genitors undergo cell death. Eur J Neurosci. 2011. 33: 1366 -1375.   DOI
4 Kwon K, Kim SW, Yu K, Kwon OY. Expression of beta-catenininteracting Protein 1 (CTNNBIP1) Gene is increased under hypothermia but decreased under additional ischemia conditions. Biomed Sci Lett. 2014. 20: 168-172.   DOI
5 Li Q, Michaud M, Canosa S, Kuo A, Madri JA. GSK-$3{\beta}$: a signaling pathway node modulating neural stem cell and endothelial cell interactions. Angiogenesis. 2011. 14: 173-185.   DOI
6 Meffre D, Massaad C, Grenier J. Lithium chloride stimulates PLP and MBP expression in oligodendrocytes via Wnt/${\beta}$-catenin and Akt/CREB pathways. Neuroscience. 2015. 284: 962-971.   DOI
7 Ray M, Rai N, Jana K, Ghatak S, Basu A, Mustafi SB, Raha S. Beta catenin is degraded by both caspase-3 and proteasomal activity during resveratrol-induced apoptosis in HeLa cells in a $GSK3{\beta}$-independent manner. Indian J Biochem Biophys. 2015. 52: 7-13.
8 Stow JL. ICAT is a multipotent inhibitor of beta-catenin. Focus on "role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions". Am J Physiol Cell Physiol. 2004. 286: C745-746.   DOI
9 Weinachter SN, Blavet N, O'Donnell RA, MacKenzie ET, Rapin JR. Models of hypoxia and cerebral ischemia. Pharmacopsychiatry. 1990. Suppl 2: 94-97.
10 Zhang H, Ren C, Gao X, Takahashi T, Sapolsky RM, Steinberg GK, Zhao H. Hypothermia blocks beta-catenin degradation after focal ischemia in rats. Brain Res. 2008. 1198: 182-187.   DOI