Browse > Article
http://dx.doi.org/10.15616/BSL.2015.21.3.144

Gender-specific Association of the ANO1 Genetic Variations with Hypertension  

Jin, Hyun-Seok (Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University)
Jung, Dongju (Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University)
Publication Information
Biomedical Science Letters / v.21, no.3, 2015 , pp. 144-151 More about this Journal
Abstract
Development of hypertension is caused by complex contributions of genetic and environmental factors. In spite of the increased understanding of hypertension, genetic factors that contribute to hypertension largely remain elusive. ANO1 gene encoding a calcium-activated chloride channel has recently been reported to affect spontaneous hypertension in the animal model. In this report, we investigated possible association of the ANO1 gene with hypertension in human with ANO1 variants found in Korean population. Fourteen polymorphisms of ANO1 gene were analyzed to be associated with hypertension. Interestingly, the six polymorphisms that showed statistically significant association were all the male subjects. The highest significant SNP was rs7127129 (OR=1.14, CI: 1.02~1.28, additive P=0.023; OR=1.24, CI: 1.03~1.49, dominant P=0.025), and other five SNPs (rs2509153, rs11235473, rs10751200, rs10898827 and rs10899928) were also statistically associated with hypertension. Consequently, we found that the genetic variants of ANO1 present statistically significant associations with hypertension in human, especially, in male. To the best of our knowledge, this study is the first report describing association of genetic polymorphisms of ANO1 with hypertension in human.
Keywords
Hypertension; Calcium-activated chloride channel; ANO1; SNP; Association;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Wang B, Li C, Huai R, Qu Z. Overexpression of ANO1/TMEM16A, an arterial $Ca^{2+}$-activated Cl- channel, contributes to spontaneous hypertension. J Mol Cell Cardiol. 2015. 82: 22-32.   DOI
2 Zhang J, Crowley SD. Role of T lymphocytes in hypertension. Current Opinion in Pharmacology. 2015. 21: 14-19.   DOI
3 Zhao W, Wang Y, Wang L, Lu X, Yang W, Huang J, Chen S, Gu D. Gender-specific association between the kininogen 1 gene variants and essential hypertension in chinese han population. J Hypertens. 2009. 27: 484-490.   DOI
4 Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, Ban HJ, Yoon D, Lee MH, Kim DJ, Park M, Cha SH, Kim JW, Han BG, Min H, Ahn Y, Park MS, Han HR, Jang HY, Cho EY, Lee JE, Cho NH, Shin C, Park T, Park JW, Lee JK, Cardon L, Clarke G, McCarthy MI, Lee JY, Lee JK, Oh B, Kim HL. A large-scale genome-wide association study of asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet. 2009. 41: 527-534.   DOI
5 Dhanachandra Singh K, Jajodia A, Kaur H, Kukreti R, Karthikeyan M. Gender specific association of RAS gene polymorphism with essential hypertension: A case-control study. Biomed Res Int. 2014. 2014: 538053.
6 Heinze C, Seniuk A, Sokolov MV, Huebner AK, Klementowicz AE, Szijarto IA, Schleifenbaum J, Vitzthum H, Gollasch M, Ehmke H, Schroeder BC, Hubner CA. Disruption of vascular $Ca^{2+}$-activated chloride currents lowers blood pressure. J Clin Invest. 2014. 124: 675-686.   DOI
7 Hong KW, Jin HS, Cho YS, Lee JY, Lee JE, Cho NH, Shin C, Lee SH, Park HK, Oh B. Replication of the Wellcome Trust genome-wide association study on essential hypertension in a Korean population. Hypertens Res. 2009. 32: 570-574.   DOI
8 Huan T, Meng Q, Saleh MA, Norlander AE, Joehanes R, Zhu J, Chen BH, Zhang B, Johnson AD, Ying S, Courchesne P, Raghavachari N, Wang R, Liu P, International Consortium for Blood Pressure GWAS (ICBP), O'Donnell CJ, Vasan R, Munson PJ, Madhur MS, Harrison DG, Yang X, Levy D. Integrative network analysis reveals molecular mechanisms of blood pressure regulation. Mol Syst Biol. 2015. 11: 799.   DOI
9 Hong KW, Jin HS, Lim JE, Cho YS, Go MJ, Jung J, Lee JE, Choi J, Shin C, Hwang SY, Lee SH, Park HK, Oh B. Nonsynonymous single-nucleotide polymorphisms associated with blood pressure and hypertension. J Hum Hypertens. 2010. 24: 763-774.   DOI
10 Horowitz B, Miskulin D, Zager P. Epidemiology of hypertension in CKD. Adv Chronic Kidney Dis. 2015. 22: 88-95.   DOI
11 Jin HS, Hong KW, Lim JE, Hwang SY, Lee SH, Shin C, Park HK, Oh B. Genetic variations in the sodium balance-regulating genes ENaC, NEDD4L, NDFIP2 and USP2 influence blood pressure and hypertension. Kidney Blood Press Res. 2010. 33: 15-23.   DOI
12 Jin HS, Eom YB. Replicated Association between SLC4A4 gene and blood pressure traits in the Korean population. J Exp Biomed Sci. 2012. 18: 377-383.
13 Kaul N, Singh YP, Bhanwer AJS. The influence of ethnicity in the association of WC, WHR, hypertension and PGC-$1{\alpha}$ (Gly482Ser), UCP2 - 866 G/A and SIRT1 - 1400 T/C polymorphisms with T2D in the population of Punjab. Gene. 2015. 563: 150-154.   DOI
14 Kelly CT, Mansoor J, Dohm GL, Chapman WH,3rd, Pender JR,4th, Pories WJ. Hyperinsulinemic syndrome: The metabolic syndrome is broader than you think. Surgery. 2014. 156: 405-411.   DOI
15 Mittelstrass K, Ried JS, Yu Z, Krumsiek J, Gieger C, Prehn C, Roemisch-Margl W, Polonikov A, Peters A, Theis FJ, Meitinger T, Kronenberg F, Weidinger S, Wichmann HE, Suhre K, Wang-Sattler R, Adamski J, Illig T. Discovery of sexual dimorphisms in metabolic and genetic biomarkers. PLoS Genet. 2011. 7: e1002215.   DOI
16 Kelly TN, Rebholz CM, Gu D, Hixson JE, Rice TK, Cao J, Chen J, Li J, Lu F, Ma J, Mu J, Whelton PK, He J. Analysis of sex hormone genes reveals gender differences in the genetic etiology of blood pressure salt sensitivity: The GenSalt study. Am J Hypertens. 2013. 26: 191-200.   DOI
17 Large WA, Wang Q. Characteristics and physiological role of the ca(2+)-activated cl- conductance in smooth muscle. Am J Physiol. 1996. 271: C435-C454.   DOI
18 Marc Y, Llorens-Cortes C. The role of the brain renin-angiotensin system in hypertension: Implications for new treatment. Prog Neurobiol. 2011. 95: 89-103.   DOI
19 Pouladi N, Bime C, Garcia JG, Lussier YA. Complex genetics of pulmonary diseases: Lessons from GWAS and next-generation sequencing. Translational Research. 2015. (in press)
20 Price PM, Hirschhorn K, Safirstein RL. Chronic kidney disease and GWAS: "The proper study of mankind is man". Cell Metabolism. 2010. 11: 451-452.   DOI
21 Rabbee N, Speed TP. A genotype calling algorithm for affymetrix SNP arrays. Bioinformatics. 2006. 22: 7-12.   DOI
22 Rudemiller NP, Mattson DL. Candidate genes for hypertension: Insights from the dahl S rat. Am J Physiol Renal Physiol. 2015. (in press)
23 Taylor JY, Kraja AT, de Las Fuentes L, Stanfill AG, Clark A, Cashion A. An overview of the genomics of metabolic syndrome. J Nurs Scholarsh. 2013. 45: 52-59.   DOI