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http://dx.doi.org/10.15616/BSL.2014.20.3.117

The Ameliorative Effect of Adenophorae Radix on Atopic Dermatitis in vivo and in vitro  

Jung, Ji-Wook (Department of Herbal Medicinal Pharmacology, College of Herbal Bio-industry, Daegu Haany University)
Kim, Su-Jin (Department of Herbal Medicinal Pharmacology, College of Herbal Bio-industry, Daegu Haany University)
Abstract
Adenophorae Radix (AR) has been used as a traditional medicine for various diseases. However, the regulatory effects of AR in atopic dermatitis are not yet understood. This study attempted to determine the pharmacological effects of AR and its constituent on both compound 48/80 or histamine-induced scratching behaviors and 2, 4-dinitrochlrobenzene (DNCB)-induced atopic dermatitis in mice. The findings of this study demonstrated that AR reduced compound 48/80 or histamine-induced scratching behaviors in mice. Treatment of AR attenuated the AD symptoms such as eczematous, erythema and dryness and serum IgE and IL-6 levels in AD model. Additionally, AR inhibited the TNF-${\alpha}$-induced the Nuclear factor-${\kappa}B$ activation in HaCaT cells. Collectively, the findings of this study provide us with novel insights into the pharmacological actions of AR as a potential molecule for therapeutic agent against atopic dermatitis.
Keywords
Adenophorae radix; Allergic inflammation; Nuclear factor-${\kappa}B$;
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