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Chungyangeum Attenuated the Allergic Inflammation in vivo and in vitro  

Kim, Su-Jin (Department of Cosmeceutical Science, Daegu Hanny University)
Lee, Jae-Ho (Department of Herbal Medicinal Pharmacology, Daegu Haany University)
Oh, Chung Hwan (Department of Herbal Medicinal Pharmacology, Daegu Haany University)
Oh, Sa-Rang (College of Pharmacy, Keimyung University)
Jung, Ji-Wook (Department of Herbal Medicinal Pharmacology, Daegu Haany University)
Publication Information
Biomedical Science Letters / v.19, no.4, 2013 , pp. 285-294 More about this Journal
Abstract
Chungyangeum (CYE) is a newly designed herbal drug formula for the purpose of treating atopic dermatitis. The aim of the present study is to elucidate whether and how CYE modulates the allergy inflammation in vitro and in vivo. We investigate to ascertain the pharmacological effects of CYE on both compound 48/80 or histamine-induced scratching behaviors and 2, 4-dinitrochlrobenzene (DNCB)-induced atopic dermatitis in mice. Additionally, we attempted to determine the effects of CYE on lipopolysaccharide (LPS)-induced inflammatory responses in macrophages. The findings of this study demonstrated that CYE reduced compound 48/80 or histamine-induced scratching behaviors and DNCB-induced atopic dermatitis in mice. The CYE inhibited the production of inflammatory cytokines as well as the activation of NF-${\kappa}B$ and caspase-1 in stimulated macrophages. Collectively, the findings of this study provide us with novel insights into the pharmacological actions of CYE as a potential molecule for use in the treatment of allergic inflammation diseases.
Keywords
Chungyangeum; Inflammatory mediators; Allergic inflammation; Nuclear factor-${\kappa}B$; Caspase-1;
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