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Mollugin-mediated Inhibition of Proinflammatory Biomarkers in Lipopolysaccharide-stimulated RAW264.7 Cells  

Kim, Jin-Kyung (Department of Biomedical Science, Catholic University of Daegu)
Park, Geun-Mook (Department of Biomedical Science, Catholic University of Daegu)
Jun, Jong-Gab (Department of Chemistry and Institute of Natural Medicine, Hallym University)
Publication Information
Biomedical Science Letters / v.18, no.4, 2012 , pp. 338-344 More about this Journal
Abstract
Mollugin is the active compound of Rubia cordifolia, a well known herb widely used in alternative medicines for the treatment of various inflammatory diseases including arthritis and uteritis. In the present study, we investigated the anti-inflammatory effects of mollugin in lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophage cells. Treatment with mollugin significantly inhibited LPS-induced release of nitric oxide, prostaglandin $E_2$, and inflammatory cytokines, such as tumor necrosis factor-${\alpha}$ and interleukin-6. In addition, mollugin suppressed LPS-induced nuclear factor-kappa B (NF-${\kappa}B$) transcriptional activity. These results suggest that mollugin inhibits LPS-induced expression of inflammatory molecules via NF-${\kappa}B$, at least in part, and indicate the potential value of mollugin as a valuable new drug candidate for the treatment of various inflammatory diseases.
Keywords
Inflammation; Mollugin; IL-6; Nitric oxide;
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