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Differential Cytokine and Immunoglobulin Expressions in the Small Intestine of Echinostoma hortense Infected BALB/c Mice  

Jo, Yoon-Kyung (Department of Clinical Laboratory Science (CLS), Dongnam Health College)
Lee, Dong-Sup (Department of Biomedical Laboratory Science (BLS), Hyejeon College)
Kim, Sung-In (BLS, College of Natural Science, Gimcheon University)
Lee, Ji-Sook (CLS, Wonkwang Health Science University)
Oh, Ji-Eun (BLS, School of Public Health, Far East University)
Sung, Ho-Joong (BLS, College of Health Science, Eulji University)
Publication Information
Biomedical Science Letters / v.18, no.3, 2012 , pp. 254-259 More about this Journal
Abstract
Infections involving Echinostoma hortense (E. hortense) are considered to more severe than infections caused by other heterophyids. Although parasite expulsion by host immune responses attenuates the symptoms of infection, the detailed mechanisms of the host immune response need to be determined, especially in local immune responses involving cytokine and immunoglobulin expressions. We infected BALB/c mice with E. hortense and examined recovery rates together with expressions of multiple cytokines and immunoglobulins in the villi and crypts of the small intestine using immunohistochemistry. We observed a close correlation between worm expulsion rates and cytokine/immunoglobulin expressions in E. hortense infected mice. This study contributes to an understanding of the relationship between the immune response and parasite expulsion in hosts.
Keywords
Echinostoma hortense; Cytokines; Immunoglobulins; Small intestines; Immunohistochemistry;
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