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Immunohistochemical Expression of Caspase 3 and Its Relationship with p53 Expression in Endometrial Cancers  

Lee, Kyung-Enn (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan)
Publication Information
Biomedical Science Letters / v.16, no.4, 2010 , pp. 307-310 More about this Journal
Abstract
Apoptosis is an important significance in the pathogenesis of cancer. Caspase 3 and p53 have been identified as important members of the apoptosis related proteins. This study was performed to define roles of caspase 3 expression and its relationship with p53 expression in endometrial cancers by immunohistochemistry. Immunoreactivity for caspase 3 was found in 13 (65.0%) out of 20 endometrial hyperplasia cases and 8 (36.4%) out of 22 endometrial cancers. Seven (87.5%) of the 8 cases with a positive caspase 3 immunoreactivity showed a positive p53 expression in 22 endometrial cancers. There were no significant associations between caspase 3 and p53 expressions. These findings suggest that caspase 3 expression might be associated with carcinogenesis of endometrial cancers. Further studies are needed to define the relationship between caspase 3 and p53 and apoptosis for examining the mechanisms of tissue-specific apoptosis related protein.
Keywords
Caspase 3; p53; Endometrial cancer; Immunohistochemistry;
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