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Pharmacetical Characteristics of Solvent Fractions Isolated from Glycyrrhiza uralensis  

Kim, Jun-Ho (Department of Fine Chemistry and New Materials, Sangji University)
Oh, Hae-Sook (Department of Food and Nutrition, Sangji University)
Publication Information
Biomedical Science Letters / v.16, no.3, 2010 , pp. 161-167 More about this Journal
Abstract
In this study, the biological activities of Glycyrrhiza uralensis were investigated, including antioxidative, fibrinolytic, thrombin inhibitory, and a-glucosidase inhibitory activity. The hot water extract of Glycyrrhiza uralensis was fractionated into hexane, $CHCl_3$, ethyl acetate, butanol, and water fractions, and each of these fractions were assayed individually. The water fraction showed the highest extraction yield of 19.45% (w/w). Using the DPPH method, the free radical scavenging activity was to be the strongest in the $CHCl_3$ fraction at 89.3%. Using the fibrin plate method, only the butanol fraction showed a substantial plasmin activity of 0.62 units/ml. In thrombin inhibitory activity tests, a 100-fold dilution of the ethyl acetate fraction showed the strongest activity of 46.9%. In the a-glucosidase inhibitory activity assay, a 100-fold dilution of the $CHCl_3$ fraction showed the strongest activity of 80.6%. In conclusion, the combined results of this study demonstrate that the extracts of Glycyrrhiza uralensis can be used as a material for the development of biofunctional foods for diabetics.
Keywords
Antioxidative activity; Fibrinolytic activity; $\alpha$-Glucosidase inhibitory activity; Glycyrrhiza uralensis; Thrombin inhibitory activity;
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