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http://dx.doi.org/10.15324/kjcls.2022.54.4.279

Investigation of Domestic and Foreign Unexpected Antibodies for Emergency Blood Transfusion  

Weonjoo, Hwang (Department of Laboratory Medicine, Pusan National University Hospital)
Sang-Hee, Lee (Department of Laboratory Medicine, Asan Medical Center)
Chang-Eun, Park (Department of Biomedical Laboratory Science, Molecular Diagnostics Research Institute, Namseoul University)
Publication Information
Korean Journal of Clinical Laboratory Science / v.54, no.4, 2022 , pp. 279-284 More about this Journal
Abstract
Certain pre-transfusion tests are not commonly performed during emergency blood transfusion. In this study, we reviewed and analyzed the data of post-blood transfusion antibody screening tests to establish the effects of unexpected antibodies causing hemolytic transfusion reactions. We reviewed information published domestically and internationally, and selected the data of 68,602 antibody screening tests and 528 antibody identification tests conducted at P hospital. We found that unexpected antibody positive (1198,1.74%), Rh type (161, 30.49%), Lewis type (67, 12.69%), others (Di (a), 28, 5.30%). The anti-E type positive was 93 (17.61%), and that of the cases with anti-C (13, 2.46%). Only data of domestic cases were included for analysis that were published before 2007, which established the presence of antibodies of the following types and numbers of cases: anti-E (196, 22.45%), anti-Le a (82, 9.39%), and anti-E+C (60, 6.87%). In 2018, anti-E (107, 17.12%), anti-E+Canti-E+C (56, 8.96%), and anti-Di a (28, 4.48%) were detected. In other domestic cases, S hospital was detect to anti-E, anti-Le a, anti-E+C. The Anti-E, anti-D, anti-E+C, and anti-C+E were detected in D hospital. In Saudi Arabia, Anti-D, anti-E, and anti-Jka was detected. The Anti-M, Anti-N, Anti-Le (a), and Anti-D were detected in India. Requests for emergency blood transfusion increased 1.8 times after the opening of the trauma center. This study has the disadvantage of being a cross-sectional study. additional studies are needed to provide basic information on alternative treatments that can increase the safety and reduce the side effects of hemolytic transfusion in emergency transfusion situations.
Keywords
Antibody screening; Anti-E+c; Emergency blood transfusion; Transfusion reaction; Unexpected antibody;
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Times Cited By KSCI : 4  (Citation Analysis)
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