Browse > Article
http://dx.doi.org/10.15324/kjcls.2020.52.4.349

Study on the Prevalence of Lung Disease of Non-Tuberculosis Mycobacterium Isolated from Respiratory Specimens in Gwangju Second Hospital over the Last 10 Years  

Baek, Hae-Gyeong (Department of Laboratory Medicine, Kwangju Christian Hospital)
Publication Information
Korean Journal of Clinical Laboratory Science / v.52, no.4, 2020 , pp. 349-355 More about this Journal
Abstract
Recently, the detection of Mycobacterium tuberculosis complex (MTBC) in respiratory specimens has decreased, and nontuberculous mycobacteria (NTM) has increased. This study examined the increase in NTM lung disease patients and their age and sex distribution compared to the increase in NTM detection in 132,359 respiratory specimens examined in a Gwangju Secondary Hospital from 2010 to 2019. Furthermore, the prevalence of pulmonary tuberculosis infection in NTM positive patients was investigated. The positive rates of the mycobacterial culture were 21.9% (1,624/7,403) in 2010 and 17.4% (1,937/11,161) in 2019. The NTM recovery rate increased from 38.0% (617/1,624) in 2010 to 72.4% (1,403/1,937) in 2019. The average diagnosis rate of NTM lung disease in the NTM positive patients was 27.1%. Among them, cases of current pulmonary tuberculosis infection decreased from 44.9% in 2010 to 23.4% in 2019, and cases of previous diagnosis or treatment decreased from 15.8% to 10.7%. Of all NTM lung diseases, 69.0% were in their 60s or older, with more females than males. In the future, according to aging and tuberculosis management policies, NTM detection is expected to increase while MTBC decreases and laboratories must pay close attention to this phenomenon and constantly monitor the test results.
Keywords
Lung disease; Mycobacterium tuberculosis complex; Nontuberculous mycobacteria; Nontuberculous mycobacteria lung disease;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Koh WJ, Kwon OJ, Jeon K, Lee KS, Park YK, Bai GH, et al. Clinical significance of nontuberculous mycobacteria isolated from respiratory specimens in Korea. Chest. 2006;129:341-348. https://doi.org/10.1378/chest.129.2.341   DOI
2 Park YS, Lee CH, Lee SM, Yang SC, Yoo CG, Kim YW, et al. Rapid increase of non-tuberculous mycobacterial lung diseases at a tertiary referral hospital in South Korea. Int J Tuberc Lung Dis. 2010;14:1069-1071. http://hdl.handle.net/10371/77375
3 Korean Academy of Tuberculosis and Respiratory Disease. National survey of mycobacterial diseases other than tuberculosis in Korea. Tuberc Respir Dis. 1995;42:277-294. https://doi.org/10.4046/trd.1995.42.3.277   DOI
4 Lee SK, Lee EJ, Kim SK, Chang J, Jeong SH, Kang YE. Changing epidemiology of nontuberculous mycobacterial lung disease in South Korea. Scand Infect Dis. 2012;44:733-738. https://doi.org/10.3109/00365548.2012.681695   DOI
5 Lee MY, Lee T, Kim MH, Byun SS, Ko MK, Hong JM, et al. Regional differences of nontuberculous mycobacteria species in Ulsan, Korea. J Thorac Dis. 2014;6:965-970. https://dx.doi.org/10.3978%2Fj.issn.2072-1439.2014.07.11   DOI
6 Koh WJ, Chang B, Jeong BH, Jeon K, Kim SY, Lee NY, et al. Increasing recovery of nontuberculous mycobacteria from respiratory specimens over a 10-year period in a tertiary referral hospital in South Korea. Tuberc Respir Dis. 2013;75:199-204. https://dx.doi.org/10.4046%2Ftrd.2013.75.5.199   DOI
7 Hong KS, Ahn JH, Choi EY, Jin HJ, Shin KC, Chung JH, et al. Microbiological distribution and clinical feature of non-tuberculous mycobacteria in the tertiary hospital in Daegu. Yeungnam Univ J Med. 2015;32:71-79. https://doi.org/10.12701/yujm.2015.32.2.71   DOI
8 Kwon YS. Diagnosis and treatment of nontuberculous mycobacterial lung disease. Korean J Med. 2012;82:274-283. https://doi.org/10.3904/kjm.2012.82.3.274   DOI
9 Choi SP, Lee BK, Min JH, Kim JH. Pathogenic classification and clinical characteristics of nontuberculous mycobacterial pulmonary disease in a national tuberculosis hospital. Tuberc Respir Dis. 2005;59:606-612. https://doi.org/10.4046/trd.2005.59.6.606   DOI
10 Hosker HS, Lam CW, Ng TK, Ma HK, Chan SL. The prevalence and clinical significance of pulmonary infection due to non-tuberculous mycobacteria in Hong Kong. Respir Med. 1995;89:3-898. https://doi.org/10.1016/0954-6111(95)90063-2   DOI
11 Shin S, Kim EC, Yoon JH. Identification of nontuberculous mycobacteria by sequence analysis of the 16s ribosomal RNA, the heat-shock protein 65 and the RNA polymerase beta-subunit genes. Korean J Lab Med. 2006;26:153-160. https://doi.org/10.3343/kjlm.2006.26.3.153   DOI
12 Primm TP, Lucero CA, Falkinham III JO. Health impacts of environmental mycobacteria. Clin Microbiol Rev. 2004;17:98-106.   DOI
13 Park CM, Heo SR, Park KU, Song J, Lee JH, Lee CT, et al. Isolation of nontuberculous mycobacteria using polymerase chain reaction-restriction fragment length polymorphism. Korean J Lab Med. 2006;26:161-167. https://doi.org/10.3343/kjlm.2006.26.3.161   DOI
14 Sakatani M. Nontuberculous mycobacteriosis: thepresent status of epidemiology and clinical studies. Kekkaku. 1999;74:377-384.
15 Brosch R, Gordon S. V, Marmiesse M, Brodin P, Buchrieser C, Eiglmeier K, et al. A new evolutionary scenario for the Mycobacterium tuberculosis complex. PNAS. 2002;99:3684-3689. https://doi.org/10.1073/pnas.052548299   DOI
16 Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007;175:367-416. https://doi.org/10.1164/rccm.200604-571ST   DOI
17 Ingen J, Boeree MJ, Dekhuijzen PN, Soolingen D. Environmental sources of rapid growing nontuberculous mycobacteria causing disease in humans. Clin Microbiol Infect. 2009;15:888-893. https://doi.org/10.1111/j.1469-0691.2009.03013.x   DOI
18 Kim JK, Rheem I. Identification and distribution of nontuberculous mycobacteria from 2005 to 2011 in Cheonan, Korea. Tuberc Respir Dis. 2013;74:215-221. https://doi.org/10.4046/trd.2013.74.5.215   DOI
19 Schlossberg D. Tuberculosis and nontuberculous mycobacterial Infections. 6th ed. Washington, DC: ASM Press; 2011.
20 Olivier KN, Weber DJ, Wallace RJ Jr, Faiz AR, Lee JH, Zhang Y, et al. Nontuberculous mycobacteria. I: multicenter prevalence study in cystic fibrosis. Am J Respir Crit Care Med. 2003;167:828-834. https://doi.org/10.1164/rccm.200207-678OC   DOI
21 WHO. Global tuberculosis report 2018. Geneva: WHO; 2018.
22 Falkinham JO. Nontuberculous mycobacteria in the environment. Clin Chest Med. 2002;23:529-551. https://doi.org/10.1016/s0272-5231(02)00014-x   DOI
23 Marras TK, Daley CL. Epidemiology of human pulmonary infection with non-tuberculous mycobacteria. Clin Chest Med. 2002;23:553-567. https://doi.org/10.1016/s0272-5231(02)00019-9   DOI