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http://dx.doi.org/10.15324/kjcls.2020.52.3.165

The Relationship between the Progression of Chronic Kidney Disease and Beta Cell Function in Non-Diabetic Korean Adults  

Kim, Hyung Rag (Department of Laboratory Medicine, St. Galloro Hospital)
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Korean Journal of Clinical Laboratory Science / v.52, no.3, 2020 , pp. 165-171 More about this Journal
Abstract
This study examined the relationship between chronic kidney disease (CKD) and the homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-B) in non-diabetic Korean adults. This study included 4,380 adults aged 20 or older (50.32±16.14) using the 2015 Korea National Health and Nutrition Examination Survey (KNHANES) data, which represents the national data in Korea. The present study had several key findings. First, in terms of HOMA-IR, after adjusting for the related variables (Model 4), the HOMA-IR (M±SE, 95% confidence interval [CI]) in group 1 (G1; estimated glomerular filtration rate [eGFR], ≥90 mL/min/1.73 ㎡), group 2 (G2; eGFR, 60~89 mL/min/1.73 ㎡), group 3a (G3a; eGFR, 30~59 mL/min/1.73 ㎡), and ≥group 3b (≥G3b; eGFR, <30 mL/min/1.73 ㎡) were 1.78±0.03 (1.73~1.83), 1.87±0.03 (1.81~1.93), 2.16±0.13 (1.91~2.42), and 2.59±0.24 (2.12~3.06), respectively. The HOMA-IR was positively associated with the progression of CKD (P<0.001). Second, in terms of the HOMA-B, after adjusting for the related variables (Model 4), the HOMA-B (M±SE, 95% CI) in G1, G2, G3a, and ≥G3b were 87.46±1.21 (85.08~89.84), 89.11±1.38 (86.40~91.81), 104.82±5.91 (93.23~116.42), and 123.97±10.87 (102.66~145.29), respectively. HOMA-B was positively associated with the progression of CKD (P<0.001). Both insulin resistance and the beta-cell function were positively associated with CKD in non-diabetic Korean adults.
Keywords
Beta cell function; Chronic kidney disease; Insulin resistance; Non-diabetes;
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1 World Kidney Day. Chronic kidney disease [Internet]. Brussels: Belgium; 2015 [cited 2020 Apr 21]. Available from: http://www.worldkidneyday.org/faqs/chronic-kidney-disease/
2 Vanholder R, Massy Z, Argiles A, Spasovski G, Verbeke F, Lameire N, et al. Chronic kidney disease as cause of cardiovascular morbidity and mortality. Nephrol Dial Transplant. 2005;20:1048-1056. https://doi.org/10.1093/ndt/gfh813   DOI
3 Duan J, Wang C, Liu, D. Qiao Y, Pan S, Jiang D, et al. Prevalence and risk factors of chronic kidney disease and diabetic kidney disease in Chinese rural residents: a cross-sectional survey. Sci Rep. 2019;9:10408. https://doi.org/10.1038/s41598-019-46857-7   DOI
4 Martin BC, Warram JH, Krolewski A, Soeldner J, Kahn C, Bergman R. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year followup study. Lancet. 1992;340:925-929. https://doi.org/doi:10.1016/0140-6736(92)92814-v   DOI
5 DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hyper tension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care. 1991;14:173-194. https://doi.org/10.2337/diacare.14.3.173   DOI
6 Chen C, Cohrs CM, Stertmann J, Bozsak R, Speier S. Human beta cell mass and function in diabetes: recent advances in knowledge and technologies to understand disease pathogenesis. Mol Metab. 2017;6:943-957. https://doi.org/10.1016/j.molmet.2017.06.019   DOI
7 Cernea S, Dobreanu M. Diabetes and beta cell function: from mechanisms to evaluation and clinical implications. Biochem Med (Zagreb). 2013;23:266-280. https://doi.org/10.11613/bm.2013.033   DOI
8 Page KA, Reisman T. Interventions to preserve beta-cell function in the management and prevention of type 2 diabetes. Curr Diab Rep. 2013;13:252-260. https://doi.org/10.1111/dom.13196   DOI
9 Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419. https://doi.org/10.1007/BF00280883   DOI
10 Srivastava N, Singh RG, Usha, Kumar A, Singh S. Insulin resistance in predialytic, nondiabetic,chronic kidney disease patients: a hospital-based study in Eastern Uttar Pradesh, India. Saudi J Kidney Dis Transpl. 2017;28:36-43. https://doi.org/10.4103/1319-2442.198114   DOI
11 Chen J, Muntner P, Hamm LL, Fonseca V, Batuman V, Whelton PK, et al. Insulin resistance and risk of chronic kidney disease in nondiabetic US adults. J Am Soc Nephrol. 2003;14:469-477. https://doi.org/10.1097/01.asn.0000046029.53933.09   DOI
12 Mima A, Qi W, Hiraoka-Yamomoto J, Park K, Matsumoto M, Kitada M, et al. Retinal not systemic oxidative and inflammatory stress correlated with VEGFexpression in rodent models of insulin resistance and diabetes. Invest Ophthalmol Vis Sci. 2012;53:8424-8432. https://doi.org/10.1167/iovs.12-10207   DOI
13 Trirogoff ML, Shintani A, Himmelfarb J, Ikizler TA. Body mass index and fat mass are the primary correlates of insulin resistance in nondiabetic stage 3-4 chronic kidney disease patients. Am J Clin Nutr. 2007;86:1642-1648. https://doi.org/10.1093/ajcn/86.5.1642   DOI
14 Lewis EJ, Hunsicker LG, Bain RP, Rohde RD; Collaborative Study Group. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. N Engl J Med. 1993;329:1456-1462. https://doi.org/10.1056/NEJM199311113292004   DOI
15 El-Atat FA, Stas SN, McFarlane SI, Sowers JR. The relationship between hyperinsulinemia, hypertension and progressive renal disease. J Am Soc Nephrol. 2004;15:2816-2827. https://doi.org/10.1097/01.ASN.0000133698.80390.37   DOI
16 Deng S, Vatamaniuk M, Huang X, Doliba N, Lian MM, Frank A, et al. Structural and functional abnormalities in theislets isolated from type 2 diabetic subjects. Diabetes. 2004;53:624-632. https://doi.org/10.2337/diabetes.53.3.624   DOI
17 Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne, Tseng YH, et al. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic islet dysfunction in human type 2 diabetes. Cell. 2005;122:337-349. https://doi.org/10.1016/j.cell.2005.05.027   DOI
18 Pham H, Robinson-Cohen C, Biggs ML, Ix JH, Mukamal KJ, Fried LF, et al. Chronic kidney disease, insulin resistance, and incident diabetes in older adults. Clin J Am Soc Nephrol. 2012;7:588-594. https://doi.org/10.2215/CJN.11861111   DOI
19 Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care. 2004;27:1487-1495. https://doi.org/10.2337/diacare.27.6.1487   DOI
20 Pham H, Utzschneider KM, de Boer IH. Measurement of insulin resistance in chronic kidney disease. Curr Opin Nephrol Hypertens. 2011;20:640-646. https://doi.org/10.1097/MNH.0b013e32834b23c1   DOI
21 Spoto B, Pisano A, Zoccali C. Insulin resistance in chronic kidney disease: a systematic review. Am J Physiol Renal Physiol. 2016;311:1087-1108. https://doi.org/10.1152/ajprenal.00340.2016