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http://dx.doi.org/10.15324/kjcls.2019.51.3.329

Laboratory Investigation of Human Rhinovirus Infection in Cheonan, Korea  

Jung, Bo Kyeung (Department of Laboratory Medicine, Dankook University Hospital)
Kim, Jae Kyung (Department of Biomedical Laboratory Science, Dankook University College of Health Sciences)
Publication Information
Korean Journal of Clinical Laboratory Science / v.51, no.3, 2019 , pp. 329-335 More about this Journal
Abstract
Annually, millions of children die from respiratory virus infections. Human rhinovirus (HRV) is a causative agent of severe respiratory infections in young, elderly, and asthmatic patients with weak immunity. In this study, 9,010 respiratory virus specimens were collected from January 2012 to December 2018 at Dankook University Hospital, Cheonan and examined by real-time reverse transcription polymerase chain reaction. Twelve respiratory viruses were detected. The mean detection rate was 21.3% (N=1,920/9,010), and the mean age of HRV-positive patients was 6.5 years (median age: 1.6 years, range: 0.0~96.0). The detection rate was the highest in July (32.4%) and the lowest in February (8.3%). When the detection rate was analyzed by age group, the detection rate was the second highest in patients aged 10~19 years. The co-infection rate of HRV was 35.3%, and the most common combination was with Adenovirus. Respiratory virus infections are known to occur in children and elderly people with weak immunity. However, in this study, the detection rate was second highest in patients aged 10~19 years. Indeed, the detection rate in this age group was more than 15%, except in January and February. These results suggested that steady-state studies on the infection patterns of HRV are required.
Keywords
Human rhinovirus; Prevalence; Respiratory virus;
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1 Stone CA, Miller EK. Understanding the association of human rhinovirus with asthma. Clin Vaccine Immunol. 2016;23:6-10.   DOI
2 Korea Centers for Disease Control and Prevention. Korea Influenza and Respiratory Viruses Surveillance System [Internet]. Seoul: Korea Centers for Disease Control and Prevention; 2019 [cited 2019 Jun 28]. Available from: http://www.cdc.go. kr/npt/biz/npp/portal/nppPblctDtaMain.do?pblctDtaSeAt=3.
3 Lee SJ, Lee SH, Ha EK, Sheen YH, Sung MS, Jung Y, et al. Prevalence of respiratory virus infection with regard to age, sex, and seasonality factors: a single center experience against children hospitalized during the 10 years. Allergy Asthma Respir Dis. 2017;5:320-325.   DOI
4 Zhao Y, Shen J, Wu B, Liu G, Lu R, Tan W. Genotypic diversity and epidemiology of human rhinovirus among children with severe acute respiratory tract infection in Shanghai, 2013-2015. Front Microbiol 2018;9:1836.   DOI
5 Monto AS. Epidemiology of viral respiratory infections. Am J Med. 2002;112(Suppl 6A):4-12.   DOI
6 Lee WM, Lemanske RF, Evans MD, Vang F, Pappas T, Gangnon R, et al. Human rhinovirus species and season of infection determine illness severity. Am J Respir Crit Care Med. 2012;186:886-891.   DOI
7 Fisman D. Seasonality of viral infections: mechanisms and unknowns. Clin Microbiol Infect. 2012;18:946-954.   DOI
8 Woo YR, Kim HJ, Kim MS, Koh HJ, Lee SG, Ahn YH. Clinical difference between single infection and coinfection with respiratory virus: the 2014 single-center study. Allergy Asthma Respir Dis. 2016;4:360-368.   DOI
9 Blomqvist S, Roivainen M, Puhakka T, Kleemola M, Hovi T. Virological and serological analysis of rhinovirus infections during the first two years of life in a cohort of children. J Med Virol. 2002;66:263-268.   DOI
10 Imaz MS, Sequeira MD, Videla C, Veronessi I, Cociglio R, Zerbini E, Carballal G. Clinical and epidemiologic characteristics of respiratory syncytial virus subgroups A and B infections in Santa Fe, Argentina. J Med Virol. 2000;61:76-80.   DOI
11 DeVincenzo JP, El Saleeby CM, Bush AJ. Respiratory syncytial virus load predicts disease severity in previously healthy infants. J Infect Dis. 2005;191:1861-1868.   DOI
12 Semple MG, Cowell A, Dove W, Greensill J, McNamara PS, Halfhide C, et al. Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis. J Infect Dis. 2005;191:382-386.   DOI
13 Marguet C, Lubrano M, Gueudin M, Le Roux P, Deschildre A, Forget C, et al. In very young infants severity of acute bronchiolitis depends on carried viruses. PLoS One. 2009;4:E4596.   DOI
14 Pinky L, Dobrovolny HM. Coinfections of the respiratory tract: viral competition for resources. PLoS One. 2016;11:E0155589.   DOI
15 International Committee on Taxonomy of Viruses. Genus: Enterovirus [Internet]. Washington: International Committee on Taxonomy of Viruses; 2019 [cited 2019 Jun 28]. Available from: https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/picornavirales/w/picornaviridae/681/genus-enterovirus.
16 Yeo NK, Hwang YJ, Kim ST, Kwon HJ, Jang YJ. Asian sand dust enhances rhinovirus-induced cytokine secretion and viral replication in human nasal epithelial cells. Inhal Toxicol. 2010;22:1038-1045.   DOI
17 Li H, McCormac MA, Estes RW, Sefers SE, Dare RK, Chappell JD, et al. Simultaneous detection and high-throughput identification of a panel of RNA viruses causing respiratory tract infections. J Clin Microbiol. 2007;45:2105-2109.   DOI
18 Kim MR, Lee HR, Lee GM. Epidemiology of acute viral respiratory tract infections in Korean children. J Infect. 2000;41:152-158.   DOI
19 Park JS. Acute viral lower respiratory tract infections in children. J Pediatr. 2009;52:269-276.
20 Kwak KJ, Kim YH, Choi HJ. Clinical characteristics of respiratory viral infection in children during spring/summer: focus on human bocavirus. Allergy Asthma Respir Dis. 2015;3:410-416.   DOI
21 Makela MJ, Puhakka T, Ruuskanen O, Leinonen M, Saikku P, Kimpimaki M, et al. Viruses and bacteria in the etiology of the common cold. J Clin Microbiol. 1998;36:539-542.   DOI