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http://dx.doi.org/10.15324/kjcls.2019.51.2.155

Antimicrobial Susceptibility Patterns of Microorganisms Isolated from Blood Culture during the Last 8 Years: 2010~2017  

Kim, Jae Soo (Department of Laboratory Medicine, Dankook University Hospital)
Gong, So Young (Department of Public Health, Dankook University Graduate School)
Kim, Jong Wan (Department of Laboratory Medicine, Dankook University College of Medicine)
Rheem, Insoo (Department of Laboratory Medicine, Dankook University College of Medicine)
Kim, Ga Yeon (Department of Public Health, Dankook University Graduate School)
Publication Information
Korean Journal of Clinical Laboratory Science / v.51, no.2, 2019 , pp. 155-163 More about this Journal
Abstract
During the time period from 2010 to 2017, out of 162,551 blood specimens, 11,233 (6.9%) specimens were positive for culture and 11,865 strains were cultured. Among the isolates, 47.8% were Gram positive cocci, 38.8% were Gram negative rods, 4.2% were Gram positive bacilli, 6.8% were fungi and 2.3% were anaerobes. When the culture results were compared according to gender, 55.0% (2,732/4,969) of the isolates were found in males and 45.0% (2,237/4,969) were isolated in females. In addition, when categorized according to age group, people in their 70s were the most separated by 28.7% (1,426/4,969) and this showed a great difference from 1.2% (62/4,969) of people in their teens. MRSA decreased significantly from 66.7% in 2016 to 46.8% in 2017. The vancomycin resistance rate of E. faecium was 35.0% (48/137). The ESBL positive rate of E. coli in intestinal bacteria was increased from 17.2% in 2010 to 28.8% in 2017, but the positive rate decreased for K. pneumoniae. 11.8% (14/119) of multidrug-resistant P. aeruginosa (MDRPA) of P. aeruginosa and 64.3% (161/252) of MDRAB of A. baumannii showed high resistance. Because the microbial susceptibility and antimicrobial susceptibility patterns of the blood specimens isolated from all the blood specimens differ according to the time period, region and patients, periodic analyses of different pathogens and understanding the changes in the degree of susceptibility to antimicrobial susceptibility have been conducted in hospitals.
Keywords
Antimicrobial susceptibility trends; Bacteremia; Blood culture;
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1 Aronson MD, Bor DH. Blood culture. Ann lntern Med. 1987;106:246-253.   DOI
2 Madeo M, Davies D, Owen L, Wadsworth P, Johnson G, Martin C. "Reduction in the contamination rate of blood cultures collected by medical staff in the accident and emergency department". Clin Eff Nurs. 2003;7:30-32. https://doi.org/10.1016/S1361-9004(03)00041-4.   DOI
3 Arpi M, Victor MA, Moller JK, Jonsson V, Hansen MM, Peterslund NA, et al. Changing etiology of bacteremia in patients with hematological malignancies in Denmark. Scand J Infect Dis. 1994;26:157-162.   DOI
4 Goldstein EJ. Anaerobic bacteremia. Clin Infect Dis. 1996;23:97-101.   DOI
5 Leibovici L, Shraga I, Drucker M, Konigsberger H, Samra Z, Pitlik SD. The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection. J Intern Med. 1998;244:379-386.   DOI
6 Raveh D, Rudensky B, Schlesinger Y, Benenson S, Yinnon AM. Susceptibility trends in bacteraemias: analyses of 7544 patient-unique bacteraemic episodes spanning 11 years (1990-2000). J Hosp Infect. 2003;55:196-203.   DOI
7 Decousser JW, Lamy B, Pina P, Allouch PY; College of Bacteriology Virology. Trends in antibiotic susceptibility of bloodstream pathogens in hospitalized patients in France, 1996 to 2007. Diagn Microbiol Infect Dis. 2010;66:292-300. https://doi.org/10.1016/j.diagmicrobio.2009.10.007.   DOI
8 CLSI. Performance standards for antimicrobial susceptibility testing; twenty-first informational supplement M100-S27. Wayne: CLSI; 2017. p31.
9 Park SH, Lee K. Prediction for the spatial distribution of medical facilities complying with the changes in the population structure in Korea. J Geol Soc Korea. 2018;53;371-385.
10 Cheong C, Lee TJ. Population ageing and increasing health care expenditures: counting on death related costs by age group. Korean Journal of Health Economics and Policy. 2017;23;127-148.
11 Chung G, Cha J, Han S, Jang H, Lee K, Yoo J, et al. Nationwide surveillance study of vancomycin intermediate Staphylococcus aureus strains in Korean hospitals from 2001 to 2006. J Microbiol Biotechnol. 2010;20:637-642.   DOI
12 Kim NH, Hwang JH, Song KH, Choe PG, Park WB, Kim ES, et al. Changes in antimicrobial susceptibility of blood isolates in a university hospital in South Korea, 1998-2010. Infect Chemother. 2012;44:275-281. https://doi.org/10.3947/ic.2012.44.4.275.   DOI
13 Koh EM, Lee SG, Kim CK, Kim M, Yong D, LeeK, et al. Microorganisms isolated from blood cultures and their antimicrobial susceptibility patterns at a university hospital during 1994-2003. Kor J Lab Med. 2007;27:265-275. https://doi.org/10.3343/kjlm.2007.27.4.265.   DOI
14 Ahn GY, Jang Sj, Lee SH, Jeong OY, Chaulagain BP, Moon DS, et al. Trends of the species and antimicrobial susceptibility of microorganisms isolated from blood cultures of patients. Korean J Clin Microbiol. 2006;9:42-50.
15 Kim MN. Multidrug-resistant organisms and healthcare-associated infections. Hanyang Med Rev. 2011;31:141-152. https://doi.org/10.7599/hmr.2011.31.3.141.   DOI
16 Edwards MS, Nizet V, et al. Group B streptococcal infections. In: Remington JS, Klein JO, editors. Infectious diseases of the fetus and newborn infant. 7th ed. Philadelphia: Elsevier Saunders; 2011. p419-469.
17 Shin KA, Shin KS, Hong SB. Change pattern of species and antimicrobial susceptibility of microorganisms isolated from blood culture during 5 Years: 2008-2012. J Exp Biomed Sci. 2013;19:245-253.
18 Kang BK, Lee HJ, Suh JT. The trends of the species and antimicrobial susceptibility of bacteria and fungi isolated from blood cultures (1986-1996). Kor J Clin Pathol. 1998;18:57-64.
19 Kim SY, Lim G, Kim MJ, Suh JT, Lee HJ. Trends in five-year blood cultures of patients at a university hospital (2003-2007). Korean J Clin Microbiol. 2009;12:163-168. https://doi.org/10.5145/KJCM.2009.12.4.163.   DOI
20 Ji MS, Choi YM, Bae ES, Kim CK. Trends in blood cultures over 4 Years. J Lab Med Qual Assur. 2017;39:141-146. https://doi.org/10.15263/jlmqa.2017.39.3.141.   DOI
21 Son BR, Shin KS. Species and antimicrobial susceptibility of microorganisms isolated from blood culture at a Chungbuk national university hospital during 5 years: 2005-2009. Chungbuk Medical Journal. 2012;22:83-95.
22 Weinstein MP. Blood culture contamination: persisting problems and partial progress. J Clin Microbiol. 2003;41:2275-2278. https://doi.org/10.1128/jcm.41.6.2275-2278.2003.   DOI
23 Favre B, Hugonnet S, Correa L, Sax H, Rohner P, Pittet D. Nosocomial bacteremia: clinical significance of a single blood culture positive for coagulase-negative staphylococci. Infect Control Hosp Epidemiol. 2005;26:697-702. https://doi.org/10.1086/502605.   DOI
24 Mirrett S, Weinstein MP, Reimer LG, Wilson ML, Reller LB. Relevance of the number of positive bottles in determining clinical significance of coagulase-negative staphylococci in blood cultures. J Clin Microbiol. 2001;39:3279-3281. https://doi.org/10.1128/jcm.39.9.3279-3281.2001.   DOI
25 Hall KK, Lyman JA. Updated review of blood culture contamination. Clin Microbiol Rev. 2006;788-802. https://doi.org/10.1128/CMR.00062-05.   DOI
26 Arthur M, Couvalin P. Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993;37:1563-1571. https://doi.org/10.1128/aac.37.8.1563.   DOI
27 Mylotte JM, Tayara A. Blood cultures: clinical aspects and controversies. Eur J Clin Microbiol Infect Dis. 2000;19:157-163.   DOI
28 Falagas ME, Kasiakou SK, Nikita D, Morfou P, Georgoulias G, Rafailidis PI. Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital. BMC Infect Dis. 2006;6:99. https://doi.org/10.1186/1471-2334-6-99.   DOI
29 Edmond MB, Wallace SE, McClish DK, Pfaller MA, Jones RN, Wenzel RP. Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin Infect Dis. 1999;29:239-244. https://doi.org/10.1086/520192.   DOI
30 Leclercq R, Derlot E, Duval J, Courvalin P. Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N Engl J Med. 1988;319:157-161. https://doi.org/10.1056/NEJM198807213190307.   DOI