Browse > Article
http://dx.doi.org/10.15324/kjcls.2019.51.1.105

Study on Correlation between Cognitive Impairment and Geriatric Depression or Geriatric Stress  

Kim, Dae Jin (Department of Neurology, Pusan National University Yangsan Hospital)
Cho, Soo-Young (Department of Neurology, Seoul National University Hospital)
Choi, Jeong Su (Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University)
Lee, Min Woo (Institute of Health Science, College of Health Science, Korea University)
Cho, Eun-Kyung (Department of Laboratory Medicine, Graduate School of Medicine, Kangwon National University)
Kang, Se-hee (Department of Neurology, Seoul National University Hospital)
Kim, Suhng Wook (Department of Health and Safety Convergence Science, Graduate School, Korea University)
Publication Information
Korean Journal of Clinical Laboratory Science / v.51, no.1, 2019 , pp. 105-113 More about this Journal
Abstract
This study examined the effects of geriatric depression and geriatric stress on cognitive impairment. In particular, the dementia groups were divided into Alzheimer's disease and vascular dementia. A normal group was used as the control group. For each group, the geriatric depression using the geriatric depression scale (GDS) and geriatric stress using the geriatric stress scale (GSS) was compared with the regression and correlation results of cognitive impairment. Statistical tests, such as descriptive statistics, Kruskall-Wallis, correlation analysis, and multiple regression analysis, were performed. For the Alzheimer's group, the GDS and GSS correlated with the cognitive impairment, but only the GDS showed a cause-and-effect relationship with cognitive impairment. In particular, the male group with Alzheimer's disease showed clear confirmation. In addition, geriatric stress was found to be associated with geriatric depression. In conclusion, geriatric depression affects the cognitive impairment directly and geriatric stress affects the cognitive ability indirectly through geriatric depression. In this study, the Alzheimer's disease, vascular dementia, and control groups had a small sample size. Therefore, the external validity in future studies can be increased using a larger sample size for each group.
Keywords
Alzheimer's disease; Cognitive impairment; Geriatric depression; Geriatric stress; Vascular dementia;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Castilla-Puentes RC, Habeych ME. Subtypes of depression among patients with Alzheimer's disease and other dementias. Alzheimer's Dement. 2010;6:63-69. http://doi.org/10.1016/j.jalz.2009.04.1232.   DOI
2 McEwen BS, Sapolsky RM. Stress and cognitive function. Curr Opin Neurobiol. 1995;5:205-216. http://doi.org/10.1016/0959-4388(95)90028-X.   DOI
3 Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, et al. Vascular dementia diagnostic criteria for research studies: Report of the NINDS-AIREN international workshop. Neurology. 1993;43:250-260. http://doi.org/10.1212/WNL.43.2.250.   DOI
4 Lezak MD, Howieson DB, Bigler ED, Tranel D. Neuropsychological assessment. 5th ed. New York: Oxford University Press; 2012.
5 Folstein MF, Folstein SE, McHugh PR. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-198. http://doi.org/10.1016/0022-3956(75)90026-6.   DOI
6 Dening T, Babu Sandilyan M. Dementia: definitions and types. Nurs Stand. 2015;29:37-42. http://doi.org/10.7748/ns.29.37.37.e9405.   DOI
7 Evans DA, Funkenstein HH, Albert MS, Scherr PA, Cook NR, Chown MJ, et al. Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. JAMA. 1989;262: 2551-2556. http://doi.org/10.1001/jama.1989.03430180093036.   DOI
8 Shin HH, So HY, Lee AY. Comparing clinical usefulness of cognitive function tests (CDT, K-MMSE, K-3MS, CDR) in dementia patient. Korean J Rehabil Nurs. 2008;11:90-98.
9 Kang YO, Na DR, Hahn SH. A validity study on the Korean mini-mental state examination in dementia patients. J Korean Neurol Assoc. 1997;15:300-308.
10 Han C, Jo SA, Jo I, Kim E, Park MH, Kang Y. An adaptation of the Korean mini-mental state examination (K-MMSE) in elderly Koreans: demographic influence and population-based norms (the AGE study). Arch Gerontol Geriatr. 2008;47:302-310. http://doi.org/10.1016/j.archger.2007.08.012.   DOI
11 Nilsson FM, Kessing LV, Sorensen TM, Andersen PK, Bolwig TG. Enduring increased risk of developing depression and mania in patients with dementia. J Neurol Neurosurg Psychiatry. 2002;73:40-44. http://doi.org/10.1136/jnnp.73.1.40.   DOI
12 Kim TH, Huh Y, Choe JY, Jeong JW, Park JH, Lee SB, et al. Korean version of frontal assessment battery: psychometric properties and normative data. Dement Geriatr Cogn Disord. 2010;29:363-370. http://doi.org/11.1159/000297523.   DOI
13 Choi SH, Na DL, Lee BH, Hahm DS, Jeong JH, Yoon SJ, et al. Estimating the validity of the Korean version of expanded clinical dementia rating (CDR) Scale. J Korean Neurol Assoc. 2001;19:585-591.
14 Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43:2412-2414. http://doi.org/10.1212/WNL.43.11.2412-a.   DOI
15 Slachevsky A, Villalpando JM, Sarazin M, Hahn-Barma V, Pillon B, Dubois B. Frontal assessment battery and differential diagnosis of frontotemporal dementia and Alzheimer disease. Arch Neurol. 2004;61:1104-1107. http://doi.org/10.1001/archneur.61.7.1104.   DOI
16 Finkel SI, Silva JC, Cohen GD, Miller S, Sartorius N. Behavioral and psychological symptoms of dementia: a consensus statement on current knowledge and implications for research and treatment. Am J Geriatr Psychiatry. 1998;6:97-100. http://doi.org/10.1097/00019442-199805000-00002.   DOI
17 Chui HC, Victoroff JI, Margolin D, Jaqust W, Shankle R, Katzman R, et al. Criteria for the diagnosis of ischemic vascular dementia proposed by the state of California Alzheimer's disease diagnostic and treatment centers. Neurology. 1992;42:473-480. http://doi.org/10.1212/WNL.42.3.473.   DOI
18 McPherson SE, Cummings JL. Neuropsychological aspects of vascular dementia. Brain Cogn. 1996;31:269-282. http://doi.org/10.1006/brcg.1996.0045.   DOI
19 Oh BH. Diagnosis and treatment for behavioral and psychological symptoms of dementia. J Korean Med Assoc. 2009;52:1048-1054. http://doi.org/10.5124/jkma.2009.52.11.1048.   DOI
20 Burns A, Jacoby R, Levy R. Psychiatric phenomena in Alzheimer's disease: disorders of behavior. Br J Psychiatry. 1990;157:86-91. http://doi.org/10.1192/bjp.157.1.86.   DOI
21 Flatt JD, Gilsanz P, Quesenberry CP, Albers KB, Whitmer RA. Post-traumatic stress disorder and risk of dementia among members of a health care delivery system. Alzheimer's Dement. 2017;14:28-34. http://doi.org/10.1016/j.jalz.2017.04.014.   DOI
22 Kang SJ, Choi SH, Lee BH, Kwon JC, Na DL, Han SH, el al. The reliability and validity of the Korean Instrumental Activities of Daily Living (K-IADL). J Korean Neurol Assoc. 2002;20:8-14.
23 Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatric Res. 1983;17:37-49. http://doi.org/10.1016/0022-3956(82)90033-4.   DOI
24 Wang HX, Wahlberg M, Karp A, Winblad B, Fratiglioni L. Psychosocial stress at work is associated with increased dementia risk in late life. Alzheimer's Dement. 2012;8:114-120. http://doi.org/10.1016/j.jalz.2011.03.001.   DOI
25 Greenberg MS, Tanev K, Marin MF, Pitman RK. Stress, PTSD, and dementia. Alzheimer's Dement. 2014;10:155-165. http://doi.org/10.1016/j.jalz.2014.04.008.
26 Ryu KH, Kang YW, Na DL, Lee KH, Chung CS. The characteristics of depression in dementia patients. Kor J Clin Psychol. 2000;19:117-129.
27 Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994;44:2308-2314. http://doi.org/10.1212/WNL.44.12.2308.   DOI
28 Cummings JL, Miller B, Hill MA, Neshkes R. Neuropsychiatric aspects of multi-infarct dementia and dementia of the Alzheimer type. Arch Neurol. 1987;44:389-393. http://doi.org/10.1001/archneur.1987.00520160031010.   DOI
29 Korczyn AD, Halperin I. Depression and dementia. J Neurol Sci. 2009;283:139-142. http://doi.org/10.1016/i.ins.2009.02.346.   DOI
30 Bos EH, Bouhuys AL, Geerts E, van Os TW, Ormel J. Stressful life events as a link between problems in nonverbal communication and recurrence of depression. J Affect Disord. 2007;97:161-169. http://doi.org/10.1016/j.jad.2006.06.011.   DOI
31 Fuhrer R, Dufouil C, Dartigues JF, PAQUID Study. Exploring sex differences in the relationship between depressive symptoms and dementia incidence: prospective results from the PAQUID study. J Am Geriatr Soc. 2003;51:1055-63. http://doi.org/10.1046/j.1532-5415.2003.51352.x.   DOI