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http://dx.doi.org/10.15324/kjcls.2018.50.4.484

Relationships of the Vitamin D and Platelet Indices in Sjögren's Syndrome  

Gunay, Nahide Ekici (Department of Clinical Biochemistry, University of Health Science, Kayseri City Training and Research Hospital)
Bugday, Irfan (Department of General Medicine, University of Health Science, Yesilhisar State Hospital)
Akalin, Tayfun (Department of General Medicine, Division of Rheumatology, University of Health Science, Kayseri City Training and Research Hospital)
Publication Information
Korean Journal of Clinical Laboratory Science / v.50, no.4, 2018 , pp. 484-491 More about this Journal
Abstract
Primer $Sj{\ddot{o}}gren Syndrome (pSS) is an autoimmune/inflammatory illness. The platelet indices (PIs) indicate the inflammatory response and activity/severity of many diseases. A vitamin D deficiency is accompanied by the increased tendency of autoimmune diseases. This study investigated whether the vitamin D levels are related to the altered platelet indices in pSS. A total of 261 individuals were included in this analytical cross-sectional study. The laboratory data of pSS patients were evaluated and the relationship between the PIs and vitamin D status was examined. According to these findings, in patients with pSS, the vitamin D levels were lower than the healthy control group (P<0.05). The vitamin D levels were negatively associated with PDW (P=0.012), but positively correlated with PCT (P<0.001). The cut-off point was obtained with receiver operating characteristics (ROC) curves for PDW: 12.53 (AUC 0.921, sensitivity 90%, specificity 85%), for PCT; 0.29 (AUC 0.660, sensitivity 68%, specificity 55%). In multivariate linear regression analysis, the most significant parameters for the effects of PDW are the following: vitamin D (${\beta}=-0.373$; t=-2.626; sig.=0.013) and plateletcrit (${\beta}=-0.308$; t=-2.13; sig.=0.040). A vitamin D deficiency may be accompanied by changes in PIs in pSS. A higher PDW and lower PCT supports the underlying inflammation, which may be vitamin D related useful parameters to consider in approaching to pSS.
Keywords
Plateletcrit; Platelet distribution width; $Sj{\ddot{o}}gren syndrome; Vitamin D;
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