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http://dx.doi.org/10.15324/kjcls.2018.50.3.217

Histological Evaluation of Bioresorbable Threads in Rats  

Lee, Chang Gun (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University)
Jung, Jaeyun (Mielle Dermatology & Plastic Surgery Network Clinic)
Hwang, Samnoh (Department of Pathology, The Catholic University of Korea, Seoul Saint Mary's Hospital)
Park, Chan Oh (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University)
Hwang, Soonjae (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University)
Jo, Minjeong (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University)
Sin, Min Hi (Department of Pathology, Wonju Severance Christian Hospital)
Kim, Hyun Ho (NEO Dr. Inc.)
Rhee, Ki-Jong (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University)
Publication Information
Korean Journal of Clinical Laboratory Science / v.50, no.3, 2018 , pp. 217-224 More about this Journal
Abstract
Thread lifting has become popular as a minimally invasive technique for facial rejuvenation. Commercially available threads are composed of poly-L-lactic acid (PLLA), polycaprolactone (PCL), or polydioxanone (PDO). However, the histological changes that occur in response to implanted threads are unclear. The aim of this study was to evaluate histological changes that occur in response to implantation with three types of bioresorbable threads (PLLA, PCL, PDO) in rat skin. PLLA, PCL and PDO threads were implanted in the dorsal skin of Sprague Dawley rats and tissue samples were harvested 2, 4, 8 and 12 weeks post-implantation. To evaluate histologic changes induced by bioresorbable face-lifting threads, tissue samples were stained with hematoxylin & eosin, Masson's trichrome stain and Herovici's collagen stain. All three threads induced neocollagenesis of type 3 collagen in the rat skin. The amount of collagen induced by the threads was dependent on the thread surface area. The PDO cavern-type thread was most effective in inducing neocollagenesis due to its extensive surface area. Our results suggest that type 3 collagen induced by bioresorbable threads depends on the thread surface area to uphold the dermis and contributes to facial rejuvenation.
Keywords
Collagen; Polydioxanone; Rat; Skin;
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