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http://dx.doi.org/10.15324/kjcls.2018.50.2.183

Effects of Omega-3 on Lipid and Liver Function Tests  

Choi, Woo-Soon (Department of Clinical Laboratory Science, Songho University)
Publication Information
Korean Journal of Clinical Laboratory Science / v.50, no.2, 2018 , pp. 183-189 More about this Journal
Abstract
Omega-3 unsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are found in fish and fish oil. Recent studies have shown that omega-3 fatty acids are effective in cancer, cardiovascular disease, immune system, cirrhosis, and nervous system disorders. In particular, omega-3 was also reported to help improve hyperlipidemia and liver function tests. On the other hand, there are few cases in Korea. This study examined whether omega-3 is effective in improving hyperlipemia and liver function by taking 1 gm/day for 2 weeks. As a result, AST was decreased in the liver function test, and GGT related to alcoholic hepatitis and fatty liver showed significant results. Omega-3 has been shown to help improve the liver function. The triglyceride, total cholesterol, and low density cholesterol associated with cardiovascular disease decreased after omega-3 ingestion, particularly high density cholesterol. Omega-3 has also been shown to improve the hyperlipidemia. Comparisons between males and females before and after the ingestion of omega-3 showed significant results in AST (P<0.01) from the male group and in GGT (P<0.01) and high density cholesterol (P<0.01) from the female group. As a result, omega-3 intake can help control and improve liver function and hyperlipidemia.
Keywords
Gamma-glutamyl transferase; High density lipoprotein cholesterol; Omega-3;
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1 Atakisi O, Atakisi E, Ozcan A, Karapehlivan M, Kart A. European Review for Medical and Pharmacological Sciences Protective effect of omega-3 fatty acids on diethylnitrosamine toxicity in rats. European Review for Medical and Pharmacological Sciences. 2013;17:467-471.
2 Zhu FS, Liu S, Chen XM, Huang ZG, Zhang DW. Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia. World J Gastroenterol. 2008;14:6395-6400.   DOI
3 Hassan KS, Hassan SK, Hijazi EG, Khazim KO. Effects of omega-3 on lipid profile and inflammation markers in peritoneal dialysis patients. Ren Fail. 2010;32:1031-1035.   DOI
4 Soden JS, Lovell MA, Brown K, Partrick DA, Sokol RJ. Failure of resolution of portal fibrosis during omega-3 fatty acid lipid emulsion therapy in two patients with irreversible intestinal failure. J Pediatr. 2010;156:327-331.   DOI
5 Kris-Etherton PM, Harris WS, Appel LJ. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Am Heart Assoc. 2002;106:2747-2757.
6 Kim JY, Kim DB, Lee HJ. Regulation on health/ functional foods in Korea. Toxicology. 2006;221:112-118.   DOI
7 Kris-Etherton PM, Harris WS, Appel LJ. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Am Heart Assoc. 2002;106:2747-2757.
8 Cho KH, Park YM. Cardiovascular disease and health functional foods. Korean J Fam Med. 2010;31:587-594.   DOI
9 Ministry of Health and Welfare, Korea Health Industry Development Institute. Ministry of Health and Welfare, Korea Centers for Disease Control and Prevention. The 3rd Korea National Health and Nutrition Examination Survey (KNHANES III) [Internet]. Cheongju: Korea Centers for Disease Control and Prevention; 2018 [cited 2018 Mar 07]. Available from: https://knhanes.cdc.go.kr/knhanes/index.do.
10 Raz R, Gabis L. Essential fatty acids and attention-deficit-hyperactivity disorder: a systematic review. Dev Med Child Neurol. 2009;51:580-592.   DOI
11 Hawkey E, Nigg JT. Omega-3 fatty acid and ADHD: blood level analysis and meta-analytic extension of supplementation trials. Clin Psychol Rev. 2014;34:496-505.   DOI
12 Simopoulos AP. Omega-3 fatty acids in health and disease and in growth and developmen. Am J Clin Nutr. 1991;54:438-463.   DOI
13 Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr. 2002;21:495-505.   DOI
14 Davidson MH. Mechanisms for the hypotriglyceridemic effect of marine omega-3 fatty acids. Am J Cardiol. 2006;98:27-33.
15 De CR. n-3 fatty acids in cardiovascular disease, N Engl J Med. 2011;364:2439-2450.   DOI
16 Gotto A, Pownall H. Manual of lipid disorders. 3rd ed. London: Lippincot and Williams; 2002.
17 Rose DP, Connoly JM. Omega-3 fatty acids as cancer chemopreventive agents. Pharmacol Ther. 1999;83:217-244.   DOI
18 Han KH. Omega-3-fatty acid and triglyceride. Korean J Med. 2012;83:724-727.   DOI
19 Hardman WE. (n-3) Fatty acids and cancer therapy. J Nutr. 2004;134:3427-3430.   DOI
20 Aronson WJ, Glaspy JA, Reddy ST, Reese D, Heber D, Bagga D. Modulation of omega-3/omega-6 polyunsaturated ratios with dietary fish oils in men with prostate cancer. Urology. 2001;58:283-288.   DOI
21 Stroes E, Bruin TD, Davidson M, Yang H, Kvarnstrom M, Lundstrom T. Omega-3 carboxylic acids in severe hypertriglyceridemia: EVOLVE II study results. Atherosclerosis. 2016;252:E232.
22 Korean Nutrition Society. 2010 dietary reference intakes for Koreans [Internet]. Seoul: Korean Nutrition Society; 2018 [cited 2018 Mar 07]. Available from: http://www.kns.or.kr/Download/2010KDRIs_open_final.pdf.