Browse > Article
http://dx.doi.org/10.3839/jksabc.2008.050

Anti-stress Effect during Long and Short-Term of Vitamin E in Mice  

Lee, Seung-Jin (Department of Bioengineering at the Postgraduate School, Konkuk University)
Go, Min-Seok (Department of Bioengineering at the Postgraduate School, Konkuk University)
Kang, Sang-Mo (Department of Bioengineering at the Postgraduate School, Konkuk University)
Publication Information
Applied Biological Chemistry / v.51, no.4, 2008 , pp. 288-293 More about this Journal
Abstract
This study was to evaluate the protective effect of vitamin E against long and short-term stress in ICR mice. Two groups which had been bred for 5 months (equivalent to human beings aged 20) were treated by immobilization stress for 8 weeks with or without vitamin E, and one out of two groups was continuously bred until they become 18 months old (equivalent to human senescence) with or without Vitamin E. Afterwards, the changes of serum and hepatic metabolites were investigated on the basis of the index of stress-related in vivo oxidative damage. As a result, it was found that stress increases serum triacylglycerol and aspartate aminotransferase (AST) in the long and short-term, and decreases serum HDL-cholesterol. In addition, stress concerned the decrease of total antioxidant status (TAS) and superoxide dismutase (SOD) as well as the increase of malondialdehyde (MDA) in liver. These results suggest that stress in one’s youth causes negative results in TG, HDL-cholesterol, AST, TAS, SOD and MDA measured in one’s senescent. The administration of vitamin E in the stressed mice decreases serum TG and AST that are increased by stress, and exerts influence on the increase of serum HDL-cholesterol. Also vitamin E recovered the values of liver TAS, SOD and MDA in the stressed mice. In conclusion, vitamin E represented protective effect in the stressed mice to some degree.
Keywords
liver tissue; serum; stress; vitamin E;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
연도 인용수 순위
1 Armendariz-Borunda, J., Seyer, J. M., Kang, A. H. and Raghow, R. (1990) Regulation of TGF-$\beta$ gene espression in rat liver intoxicated with carbon tetrachloride. FASEB J. 4, 215-221   DOI
2 Castilla, A., Prieto, J. and Fausto, N. (1991) Transforming growth factor $\beta$1 and $\alpha$ in chronic liver disease. N. Eng. J. Med. 324, 933-940   DOI   ScienceOn
3 Chow, C. K. (1991) Vitamin E and oxidative stress. Free Radical Bio. Med. 11, 215-232   DOI   ScienceOn
4 Tiidus, P. M. and Houston, M. E. (1995) Vitamin E status and response to exercise training. Sports Med. 20, 12-23   DOI   ScienceOn
5 Collett, C., Pares-Herbute, N., Monnier, L. H. and Cartry, E. (1988) Platelet function in type I diabetes: Effects of supplementation with large doses of vitamin E. Am. J. Clin. Nutr. 47, 256-261   DOI
6 Lovin, R., Cottle, W., Pyke, I., Davanagh, M. and Belcastro, A. N. (1987) Are induces of free radical damage related to exercise intensity. Eur. J. Appl. Physiol. 6, 313-316
7 Lawler, J. M., Powers, S. K., Dijk, H. V., Visser, T., Kordus, M. J. and Ji, L. L. (1994) Metabolic and antioxidant enzyme activities in the diaphragm: effects of acute exercise. Res. Physiol. Neurobiol. 96, 139-149
8 Yun Mei, K. R., Gawai., Zhongzhen, Nie., Vickmar. and Robert, H. Helfert. (1999) Age related reductions in the activities of antioxidant enzymes in the rat inferior colliculus. Hearing. Res. 135, 169-180   DOI   ScienceOn
9 Okimoto, K., Hamazaki, K., Lwagaki, H., Orita, K. and Mori, A. (1995) Effect of picibanil on the scavenging effect of free radicals produced during liver regeneration in the rat. Acta. Med. Okayama. 49, 75-79
10 Bedossa, P., Houglum, K., Trautwein, C., Holstege, A. and Chojkier, M. (1994) Stimulation of collagen $\alpha$ I(I) gene espression is associated with lipid peroxidation in hepatocellular injury: a Link tot issue fibrosis. Hepatology. 19, 1262-1271
11 Livne, E., Laufer, D. and Blumenfeld, I. (1997) Comparison of in vitro response to growth hormone by chondrocytes from mandibular condyle cartilage of young and old mice. Calcified. Tissue. Int. 7, 61-62
12 Traber, M. G. (2001) Does vitamin E decrease heart attack risk summary and implications with respect to dietary recommendations. J. Nutr. 131, 395-397   DOI
13 Scarpa, M., Rigo, A., Maiorino, M., Ursini, F. and Gregolin, C. (1984) Formation of $\alpha$-tocopherol radical and recycling of $\alpha$- tocopherol by ascorbate during peroxidation of phophatidylcholin liposomes. An electron paramagnetic resorbance study. Biochem. Biophys. Res. Comm. 801, 215-219
14 Elliot, G. R. and Eisdorfer, C. (1982) Stress and human health. New York, Springer, 2, 1-20
15 Hernry, J. B. (2007) Measurement of lipids and evaluation of lipid disorders. In Clinical diagnosis and management by Laboratory Methods, Levy, M. D. pp. 171-198, Elsevier Science Health Science div, Churchill
16 Halliwell, B. and Gutteridge, J. M. C. (1989) In Free radicals in biology and medicine, (2nd ed.) Clarendon Press, Oxford
17 Brenner, D. A., Veloz, L., Jaenisch, R. and Alcorn, J. M. (1993) Stimulation of the collagen $\alpha$ I (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. Hepatology. 17, 287-292
18 Park, S. Y. (2001) Study on the oxidative damage induced by stress and its recovery in mice. Department of Microbial Engineering. Dissertation of Ph. D. Konkuk Universtiy. Seoul
19 Rao, M. S., Pareddy, K., Abecassis, M. and Hashimoto, T. (2001) Regeneration of liver with marked fatty change following partial hepatectomy in rats. Digest. Dis. Sci. 46, 1821-1826   DOI   ScienceOn
20 Cherubini, A., Zuliani, G. and Costantini, F. (2001) High vitamin E plasma levels and low low-density lipoprotein oxidation are associated with the absence of atheros-clerosis in octogenarians. J. Am. Geriatr. Soc. 49, 651-654   DOI   ScienceOn
21 Avellini, L., Chiaradia, E. and Gaiti, A. (1999) Effect of exercise training, selenium and vitamin E on some free radical sacvengers in horse. Comp. Biochem. Phys. B. 123, 147-154   DOI   ScienceOn
22 Ji, L. L. (1993) Blood glutathione status during exercise; Effect of carbohydrate supplementation. J. Appl. Physiol. 74, 788-792. 26   DOI
23 Kruit, J. K., Groen, A. K., van Berkel, T. J. and Kuipers, F. (2006) Emerging roles of the intestine in control of cholesterol metabolism. World. J. Gastroenterol. 12, 6429-6439   DOI
24 Gittleman, B., Shatin, L., Bierenbaum, M. L., Fleisohman, A. I. and Hqyton, T. (1968) Effects of quantified stressful stimuli on blood lipids in man. J. Nutr. Ment. Dis. 147, 196-201   DOI
25 Woo, Y. S. (1992) Studies on the effects of slaughter stress on the blood picture and serum chemical values of pigs. Dissertation of Ph. D. Konkuk Universtiy. Seoul
26 Thomson, C. B. (1995) Apoptosis in the pathogenesis and treatment of disease. Science. 267, 1456-1462   DOI   ScienceOn
27 Lehtonen, A. J. (1978) The effect of vigorous physical activity at work on serum lipids with a special reference to serum highdensity lipoprotein cholesterol. Acta. Physiol. Scand. 104, 117-121   DOI   ScienceOn
28 Lim, S. S., Kim, M. H. and Lee, J. H. (1997) Effect of Artemisia princeps var orientalis and Circium japonicum var ussuriense on liver function body lipid and bile acid of hyperlipidemic rat. Korean J. Nutr. Soc.. 30, 797-802   과학기술학회마을
29 Nakatsukasa, H., Evarts, R. P., Hsia, C. C. and Thorgeirsson, S. S. (1990) Transforming growth factor-$\beta^1$1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver. Lab Invest. 63, 171-180
30 Kissebah, A. H. (1974) Stress hormines and lipid metabolism. Proc. R. Soc. Med. 67, 665-667
31 Howard, N. H., Dieter, M. K., Poetro, A., Gabriele, B. B., Giuseppe, G., Juliana, H., Hazel, P. and Alex, S. (1994) Biochemical and cytotoxic characterstics of an in vivo circulating oxidized LDL. J. Lipid Res. 35, 669-677
32 Ghrousos, G. P. (2000) The role of stress and the hypothalamicpituitary-adrenal axis in the pathogenesis in the metabolic syndrome: Neuroendocrine and target tissue-related causes. Int. J. Obesity. 24, S50-S55   DOI
33 Kagan, V. E., Spirichev, V. B. and Serbinova, E. A. (1994) The significance of vitamin E and free radicals in physical exercise. In Nutrition in exercise and sport, Wolinsky, I. (2nd ed.) pp. 185-213, CRC Press, Boca Raton
34 Gale, C. R., Ashurst, H. E., Powers, H. J. and Martyn, C. N. (2001) Antioxidant vitamin status and carotid atherosclerosis in the elderly. Am. J. Clin. Nutr. 74, 402-408   DOI
35 Gutteridge, J. N. C. (1995) Lipid peroxidation and antioxidants as biomarker of tissue damages. Clin. Chem. 41, 1819-1828