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Synthesis and Biological Activities of Aklyl Thiosulfi(o)nates  

Jung, Hyun-Jin (Department of Applied Biology & Chemistry Konkuk University)
Kyung, Kyu-Hang (Department of Food Science, Sejong University)
Jung, Yi-Sook (Department of Physiology, Department of Molecular Science & Technology, Ajou University)
Kyung, Suk-Hun (Department of Molecular Biotechnology, Konkuk University)
Publication Information
Applied Biological Chemistry / v.51, no.3, 2008 , pp. 183-187 More about this Journal
Abstract
Alkyl thiosulfi(o)nates, analogs of allyl-2-propene-1-thiosulfinate isolated from Allium sativum and having antibacterial activity, were chemically synthesized and their biological activities were investigated. Alkyl thiosulfinates were prepared by oxidation of corresponding disulfides with organic peroxy acid, while alkyl thiosulfonates could be obtained by oxidation of the alkyl thiosulfinates using sodium periodate. All synthetic thiosulfi(o)nates showed antibacterial activity against Staphylococcus aureus B33 and antifungal activity against Candida utilis ATCC42416. Further more synthetic alkyl thiosulfonates displayed antioxidant activity and have also prevention effect of platelet aggregation induced by collagen in rat.
Keywords
Alkyl thiosulfi(o)nate; alkyl thiosulfonate; anti-aggregation activity; antibacterial activity; antioxidant; garlic;
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