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Protective Effect of Neuronal Cell on Glutamate-induced Oxidative Stress from Viola mandshurica Extracts  

Lee, Mi-Ra (Department of Food Science and Biotechnology, Kyungnam University)
Han, Chang-Suk (Laboratory of Herbal Medicine, Daehandang Herb Clinic)
Han, Dong-Youl (Laboratory of Herbal Medicine, Daehandang Herb Clinic)
Park, Eun-Ju (Department of Food and Nutrition Kyungnam University)
Lee, Seung-Cheol (Department of Food Science and Biotechnology, Kyungnam University)
Park, Hae-Ryong (Department of Food Science and Biotechnology, Kyungnam University)
Publication Information
Applied Biological Chemistry / v.51, no.1, 2008 , pp. 79-83 More about this Journal
Abstract
The present study describes glutamate which is known as excitatory neurotransmitter is related with oxidative damages and the Viola mandshurica extracts. Showed protective effects against glutamate-induced cytotoxicity. The protective effect of antioxidant on the glutamate treated N18-RE-I05 cells was determined by a MTT reduction assay. The neuroprotective effect of methanol, ethanol, and acetone extracts from V. mandshurica against glutamate-induced cytotoxicity was assessed by the results of an MTT reduction assay. Among the three extracts, the acetone extract showed the highest protective effect by the results of an lactate dehydrogenase release assay. Therefore, these results suggest that V. mandshurica extracts could be a new potential candidate against glutamate-induced oxidative stress.
Keywords
glutamate toxicity; N18-RE-105 cells; oxidative stress; Viola mandshurica;
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Times Cited By KSCI : 7  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
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