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Development of Biologically Active Compounds from Edible Plant Sources-XIX. Isolation of Inhibitory Compound on LDL-Oxidation from the Aerial Parts of Sajabalssuk (Artemisia princeps PAMPANINI, Sajabalssuk)  

Bang, Myun-Ho (Ganghwa Agricultural R&D Center)
Song, Myoung-Chong (The Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University)
Han, Min-Woo (The Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University)
Lee, Dae-Young (The Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University)
Jo, Jin-Kyung (The Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University)
Chung, Hae-Gon (Ganghwa Agricultural R&D Center)
Jeong, Tae-Sook (National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology)
Lee, Kyung-Tae (Department of Biochemistry, College of Pharmacy, Kyung Hee University)
Choi, Myung-Sook (Department of Food Science and Nutrition, Kyungpook National University)
Baek, Nam-In (The Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University)
Publication Information
Applied Biological Chemistry / v.50, no.3, 2007 , pp. 224-227 More about this Journal
Abstract
Sajabalssuk (Artemisia princeps PAMPANINI) was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and $H_{2}O$, successively. From the EtOAc fraction, two phenylpropanoids were isolated through the repeated silica gel and ODS column chromatographies. From the results of physico-chemical data including NMR, MS and IR, the chemical structures of the phenylpropanoids were determined as eugenol (1) and (-)-sesamin (2). They were the first to be isolated from Sajabalssuk (Artemisia princeps PAMPANINI, Sajabalssuk). Also, eugenol inhibited LDL-oxidation with the inhibitory activity of 87.8 ${\pm}$ 1.0% at a concentration of 40 ${\mu}g/ml$.
Keywords
Artemisia princeps PAMPANINI; eugenol; (-)-sesamin; LDL-oxidation;
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Times Cited By KSCI : 4  (Citation Analysis)
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