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Synthesis and Phytopathogenic Activities of Isopropylphenyl Derivatives  

Jang, Do-Yeon (Department of Biotechnology, Soonchunhyang University)
Choi, Kyoung-Gil (Department of Biotechnology, Soonchunhyang University)
Lee, Byung-Ho (Dongbu Hannong Chemical, Daeduck Science Town)
Kim, Tae-Jun (Dongbu Hannong Chemical, Daeduck Science Town)
Jung, Bong-Jin (Dongbu Hannong Chemical, Daeduck Science Town)
Choi, Won-Sik (Department of Biotechnology, Soonchunhyang University)
Publication Information
Applied Biological Chemistry / v.50, no.3, 2007 , pp. 178-186 More about this Journal
Abstract
42 compounds such as ester, sulfonyl ester, phosphoyl ester and ether derivatives of 4-isopropylphenol (I) and 2-isopropylphenol (II) were synthesized. These derivatives were identified by IR, GC/MS and $^{1}H-NMR$ spectra. Their in vitro antifungal activities were tested against 10 plant pathogenic fungi. Among them, several compounds showed potent in vitro antifungal activity. The selected compounds showing potent in vitro antifungal activity were tested for their in vivo antifungal acitvities against 5 plant diseases such as rice blast, rice sheath blast, cucumber anthracnose, cucumber gray mold and tomato late blight. As a result, 2-isopropylphenyl piperonyloate (II-7a) showed a potent in vivo antifungal activity against cucumber anthracnose and tomato late blight, 4-isopropylphenyl 4-methoxybenzenesulfonate (I-6b) effectively inhibited the development of rice blast.
Keywords
Antifungal activity; 2-Isopropylphenol; 4-Isopropylphenol; Phytopathogen;
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