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The Roles of Hydrogen Bonds in 2,9-(N,N-Dimethylethylenediaminomethyl)-1,10-phenanthroline Molecule as a New Ligand Compound of Artificial DNase  

Sung, Nack-Do (Division of Applied Biology and Chemistry, College of Agriculture and Life Science, Chungnam National University)
Park, Kyeng-Yong (Research Center for Transgenic Cloned Pigs, Chungnam National University)
Publication Information
Applied Biological Chemistry / v.48, no.4, 2005 , pp. 326-330 More about this Journal
Abstract
In the catalytic hydrolysis of 2',3'-cAMP by the Cu(II) complexes of 2,9-(N,N-dimethylethylenediamino)-1,10-phenanthroline (A) and 2,9-(N,N-dimethylethylenediaminomethyl)-1,10-phenanthroline (B) that are designed as a new ligand molecule of artificial DNase, due to the four intramolecular H-bonds forming between amino groups of ligand molecule and phosphoryl group of 2',3'-cAMP. It is anticipated that Cu(II) complexes of (A) and (B) are able to promote a rate that is as much as seventy thousand times faster than the catalytic hydrolysis rate of 2',3'-cAMP by Cu(II) complexes of 2,9-dimethyl-o-phenanthroline.
Keywords
Artificial DNase; 2,9-(N,N-dimethylethylenediamino)-1,10-phenanthroline; H-bond; hydrolysis of phosphodiester; 2,9-(N,N-Dimethylethylenediaminomethyl)-1,10-phenanthroline;
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