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Pathogenesis, Dianosis, and Prophylactic Vaccine Development for Foot-and-Mouth Disease  

Moon, Sun-Hwa (Department of Genetic Engineering, Sungkyunkwan University)
Yang, Joo-Sung (Department of Genetic Engineering, Sungkyunkwan University)
Publication Information
Applied Biological Chemistry / v.48, no.4, 2005 , pp. 301-310 More about this Journal
Abstract
Foot-and-mouth disease (FMD) is a highly contagious disease of mammals and has a great potential for causing severe economic loss in susceptible cloven-hoofed animals, such as cattle, pigs, sheep, goats and buffalo. FMDV, a member of the Aphthovirus genus in the Picornaviridae family, is a non-enveloped icosahedral virus that contains a positive sense RNA of about 8.2 kb in size. The genome carries one open reading frame consisting of 3 regions: capsid protein coding region P1, replication related protein coding region P2, and RNA-dependent RNA polymerase coding region P3. FMDV infects pharynx epithelial cell in the respiratory tract and viral replication is active in lung epithelial cell. Morbidity is extremely high. A FMD outbreak in Korea in 2002 caused severe economic loss. Although intense research is undergoing to develop appropriate drugs to treat FMDV infection, there is no specific therapeutic for controlling FMDV infection. Moreover, there is an increasing demand for the development of vaccine strategies against FMDV infection in many countries. In this report, more effective prevention strategies against FMDV infection were reviewed.
Keywords
FMDV; DNA vaccine; Edible vaccine; Peptide vaccine;
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